Essential Aspects of Atopic Dermatitis

Rajka, G

doi:10.1007/978-3-642-74766-3

Cited by 200 publications

(126 citation statements)

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“…The distribution pattern of the skin lesions changes during the patient's lifetime from more generalized eruptions with oozing and crusted lesions to the adult distribution pattern of¯exural eczema with licheni®cation and a scaly, xerotic, dry uninvolved skin. This so called``dryness of skin'' actually describes the reduced softness, smoothness, and water and lipid content of the skin surface (7,18).…”

Section: Basic Clinical Aspectsmentioning

confidence: 99%

“…During the last 10 years, some excellent textbooks (7,8) and review articles (9±12) on the clinical and pathogenetic aspects of this condition have been published. New approaches, which may become important for our understanding of the disease (13,14), as well as novel therapeutic strategies (15±17), have evolved in the last decade of the 20th century.…”

Section: Introductionmentioning

confidence: 99%

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Atopic dermatitis: from the genes to skin lesions

Wollenberg

Bieber

2000

Allergy

118

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Section: Basic Clinical Aspectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Atopic dermatitis: from the genes to skin lesions

Wollenberg

Bieber

2000

Allergy

118

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“…In particular, there is increasing evidence that similar mechanisms are involved in the pathogenesis of atopic diseases, e.g. allergic bronchial asthma, allergic rhinitis and conjunctivitis, and atopic dermatitis (AD) (14,15,29). Recent studies support the concept of an immunologic basis of these disorders, and specific alterations of T-lymphocyte functions may be of major relevance.…”

mentioning

confidence: 99%

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

Kapp

1993

Allergy

156

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Currently, there is a large body of evidence that atopic dermatitis (AD) has an Immunologic basis. Atopy‐specific helper T cells (Th2‐like T cells) may play a pathogenetic role by producing and releasing cytokines relevant for the allergic inflammation, such as IL‐4, IL‐5, and other growth factors. Eosinophils are believed to be of major importance as effector cells mediating the pathogenetically relevant late‐phase reaction which is associated with a significant destruction of the surrounding tissue. Accordingly, a significant preactivation of peripheral blood eosinophils was detected in AD patients, leading to an enhanced susceptibility of these cells to distinct stimuli such as IL‐5. Toxic proteins, such as eosinophil cationic protein (ECP), contained in the matrix and the core of secondary granules of eosinophils, may play an important role by propagating the allergic inflammatory process and by modulating the immune response. The pathogenetic role of eosinophils in AD is further supported by the detection of these proteins in the eczematous skin of patients. Furthermore, recent data point to a significant correlation between disease activity and deposition of eosinophil granule content: ECP serum levels were significantly increased in AD patients. In addition, ECP levels correlated with the disease activity. Moreover, clinical improvement was associated with a decrease of both the clinical score and serum ECP levels. These data clearly indicate that activated eosinophils may play a major role in the allergic inflammatory process of AD. Therefore, modulation of eosinophil activation could prove to be an important pharmacologic modality for the treatment of AD.

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“…early age at onset, dryness of the skin, tendency toward cutaneous infections, recurrent conjunctivitis, increased serum IgE level, positive immediate skin test reactions and various functional, vascular abnormalities. The aetiology of AD is unknown, but it is assumed to be multifactorial (55,56). The primary pathomechanisms are unknown, although research during recent decades has shown several pharmacophysiological, biochemical and immunological abnormalities, as extensively reviewed by several authors (55)(56)(57)(58)(59)(60)(61).…”

Section: General Aspectsmentioning

confidence: 99%

“…The aetiology of AD is unknown, but it is assumed to be multifactorial (55,56). The primary pathomechanisms are unknown, although research during recent decades has shown several pharmacophysiological, biochemical and immunological abnormalities, as extensively reviewed by several authors (55)(56)(57)(58)(59)(60)(61). The role of IgE in AD is unclear, and hence, the term "atopic" is sometimes criticized.…”

Section: General Aspectsmentioning

confidence: 99%

Pathophysiology of itching in urticaria and atopic dermatitis

Wahlgren

1992

Allergy

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Essential Aspects of Atopic Dermatitis

Cited by 200 publications

References 0 publications

Atopic dermatitis: from the genes to skin lesions

Atopic dermatitis: from the genes to skin lesions

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

Pathophysiology of itching in urticaria and atopic dermatitis

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