Essential and toxic metals in serum of individuals with active pulmonary tuberculosis in an endemic region

Sepehri, Zahra; Mirzaei, Nima; Sargazi, Aliyeh; Mishkar, Abolfazl Panahi; Kiani, Zohre; Oskoee, Hamid Owaysee; Arefi, Donya; Ghavami, Saeid

doi:10.1016/j.jctube.2017.01.001

Cited by 13 publications

(10 citation statements)

References 51 publications

(56 reference statements)

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“…Low iron concentration is known in patients with TB and HIV 23,24. Low iron concentration in TB and TB-HIV-coinfected patients was reported in a previous study in the north-west of Ethiopia,25 and in Iran,26 which was similar to our finding. Iron has a significant role in the myeloperoxidase-dependent generation of hypochlorous acid which is a microbicidal factor 27.…”

Section: Discussionsupporting

confidence: 92%

The serum concentration of vitamin B12 as a biomarker of therapeutic response in tuberculosis patients with and without human immunodeficiency virus (HIV) infection

Gebremicael¹,

Alemayehu²,

Sileshi³

et al. 2019

IJGM

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BackgroundPrior to clinical trials of new tuberculosis (TB) drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients.MethodsMicronutrients concentration level was determined from a total of 262 study participants with five clinical groups: 57 TB patients coinfected with HIV (HIV+TB+), 87 active TB Patients (TB cases), 71 HIV infected without active and latent TB infection (HIV+TST-), 22 latent TB infection (TST+) and 25 healthy controls (TST-). Vitamin A concentration was measured using high-performance liquid chromatography (HPLC), whereas iron and vitamin B12 concentrations were measured using Cobas® 6000 analyzer.ResultThe serum concentration levels of iron, vitamin A and vitamin B12 had a significant difference between active TB and latent (LTBI) or healthy controls. Six months after treatment, the serum concentration levels of vitamin A, vitamin B12 and iron in tuberculosis became indistinguishable from the levels of LTBIs and healthy control individuals. The concentration levels of iron and vitamin B12 in HIV+TB+patients at the end of TB treatment were normalized to the levels observed in healthy controls (TST–) regardless of HAART treatment. However, the concentration level of vitamin A in HIV+TB+patients HAART untreated at the end of TB treatment was not normalized to the levels observed in healthy controls (TST–) or HAART untreated HIV+TST–.ConclusionDetecting serum concentration levels of vitamin B12 and vitamin A might be used as a biomarker of the diagnostic method of active TB regardless of HIV-infected individuals. Moreover, detecting serum concentration of vitamin B12 might also be used for TB treatment responses monitoring biomarker in TB-HIV-co-infected individuals regardless of HAART (in)eligibility and therapy.

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Section: Discussionsupporting

confidence: 92%

The serum concentration of vitamin B12 as a biomarker of therapeutic response in tuberculosis patients with and without human immunodeficiency virus (HIV) infection

Gebremicael¹,

Alemayehu²,

Sileshi³

et al. 2019

IJGM

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“…This regulation can occur at the transcriptional level, via DNA-binding metal-responsive transcriptional repressors which are responsible for the regulation of the transcription process as in many bacteria as M. tuberculosis. 4 From the results was found the means of zinc increased gradually during anti-tuberculosis and after therapy. The result was in agreement with a study of 6 who found that a lessened concentration level of serum Zn at the initial stage of treatment when compared to control, in men and in women (P < 0.05).…”

Section: Discussionmentioning

confidence: 95%

“…In spite of its biological and physiological assistances, its excessive level is toxic and might cause inhibition of M. tuberculosis growth. 4…”

Section: Introductionmentioning

confidence: 99%

Effects of anti-Tuberculosis Drugs on the Level of some Nutritional Factors Among Patients with tuberculosis

Chabuck,

Alhelli,

Jasim

2021

J. Contemp. Med. Sci.

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Objectives:The study aimed to assess changes in the level of some nutritional elements including zinc and copper for tuberculosis patients before, during and after anti-tuberculosis therapy. Methods: Whole blood samples are collected from 120 tuberculosis patients who are admitted to specialist clinic of the respiratory diseases in Babylon province, within a period from November 2020 to January 2021. Results: Out of whole TB patients, (66) ones were males and the remaining (54) were females, the age of patients ranging from (13-70) years. Sixty, apparently healthy control groups who had no Tuberculosis history were chosen. Using spectrophotometer for estimating the level of Zinc and copper. In TB patients the zinc level was increased during and after anti-tuberculosis therapy, but the level of zinc lower in patients after therapy compared with controls. The level of copper was decreased during and after the course of anti-tuberculosis, but the level of copper higher in patients after therapy compared with controls. Conclusion: These parameters could be used in follow-up as the achievement of TB therapy success.

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“…Trace elements (Se, Cu, and Zn) Se levels were low in approximately 30% of patients, followed by Zn (* 25%) and Cu (3%). Lower levels of these metals have been observed in patients diagnosed with various infectious diseases (Skalny et al 2021;Weiss and Carver 2018;Oh et al 2019;Sepehri et al 2017). Se is an essential trace element in humans that supports antioxidant defense systems (Burk 2002) and, consequently, plays a role in immune-related diseases (Huang et al 2012;Hoffmann and Berry 2008).…”

Section: Discussionmentioning

confidence: 99%

Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity

et al. 2022

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The role of micronutrient deficiency in the pathogenesis of COVID-19 has been reviewed in the literature; however, the data are limited and conflicting. This study investigated the association between the status of essential metals, vitamins, and antioxidant enzyme activities in COVID-19 patients and disease severity. We recruited 155 patients, who were grouped into four classes based on the Adults guideline for the Management of Coronavirus Disease 2019 at King Faisal Specialist & Research Centre (KFSH&RC): asymptomatic (N = 16), mild (N = 49), moderate (N = 68), and severe (N = 22). We measured serum levels of copper (Cu), zinc (Zn), selenium (Se), vitamin D 3 , vitamin A, vitamin E, total antioxidant capacity, and superoxide dismutase (SOD). Among the patients, 30%, 25%, 37%, and 68% were deficient in Se (\ 70.08 lg/L), Zn (\ 0.693 lg/mL), vitamin A (\ 0.343 lg/mL), and vitamin D 3 (\ 20.05 lg/L), respectively, and SOD activity was low. Among the patients, 28% had elevated Cu levels ([ 1.401 lg/mL, KFSH&RC upper reference limit). Multiple regression analysis revealed an 18% decrease in Se levels in patients with severe symptoms, which increased to 30% after adjusting the model for inflammatory markers. Regardless of inflammation, Se was independently associated with COVID-19 severity. In contrast, a 50% increase in Cu levels was associated with disease severity only after adjusting for C-reactive protein, reflecting its possible inflammatory and pro-oxidant role in COVID-19 pathogenesis. We noted an imbalance in the ratio between Cu and Zn, with * 83% of

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Essential and toxic metals in serum of individuals with active pulmonary tuberculosis in an endemic region

Cited by 13 publications

References 51 publications

<p>The serum concentration of vitamin B<sub>12</sub> as a biomarker of therapeutic response in tuberculosis patients with and without human immunodeficiency virus (HIV) infection</p>

<p>The serum concentration of vitamin B<sub>12</sub> as a biomarker of therapeutic response in tuberculosis patients with and without human immunodeficiency virus (HIV) infection</p>

Effects of anti-Tuberculosis Drugs on the Level of some Nutritional Factors Among Patients with tuberculosis

Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity

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