Essential Amino Acids, Vitamins, and Minerals Moderate the Relationship between the Right Frontal Pole and Measures of Memory

Key, Mickeal N.; Zwilling, Christopher E.; Talukdar, Tanveer; Barbey, Aron K.

doi:10.1002/mnfr.201801048

Cited by 11 publications

(6 citation statements)

References 42 publications

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“… 42 On the other hand, a growing amount of evidence has pinpointed the availability and metabolism of the essential amino acid, vitamins, and minerals nutrient pattern moderates the effect of brain structure on cognitive function in old age. 43 It is interesting to note that B. pseudocatenulatum showed positively associated with essential amino acid pathways such as L− isoleucine biosynthesis I (from threonine) L− valine biosynthesis L− lysine biosynthesis VI. The above information suggests that B. pseudocatenulatum can be a particular beneficial bacterium in the improvement of brain function through modulating the availability and metabolism of the essential amino acid as a key regulator of the gut-brain axis.…”

Section: Discussionmentioning

confidence: 99%

The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function

et al. 2022

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Human longevity has a strong familial and genetic component. Dynamic characteristics of the gut microbiome during aging associated with longevity, neural, and immune function remained unknown. Here, we aim to reveal the synergistic changes in gut microbiome associated with decline in neural and immune system with aging and further obtain insights into the establishment of microbiome homeostasis that can benefit human longevity. Based on 16S rRNA and metagenomics sequencing data for 32 longevity families including three generations, centenarians, elderly, and young groups, we found centenarians showed increased diversity of gut microbiota, severely damaged connection among bacteria, depleted in microbial-associated essential amino acid function, and increased abundance of anti-inflammatory bacteria in comparison to young and elderly groups. Some potential probiotic species, such as Desulfovibrio piger, Gordonibacter pamelaeae, Odoribacter splanchnicus, and Ruminococcaceae bacterium D5 were enriched with aging, which might possibly support health maintenance. The level of Amyloid-β (Aβ) and brain-derived neurotrophic factor (BDNF) related to neural function showed increased and decreased with aging, respectively. The elevated level of inflammatory factors was observed in centenarians compared with young and elderly groups. The enriched Bacteroides fragilis in centenarians might promote longevity through up-regulating anti-inflammatory factor IL-10 expression to mediate the critical balance between health and disease. Impressively, the associated analysis for gut microbiota with the level of Aβ, BDNF, and inflammatory factors suggests Bifidobacterium pseudocatenulatum could be a particularly beneficial bacteria in the improvement of impaired neural and immune function. Our results provide a rationale for targeting the gut microbiome in future clinical applications of aging-related diseases and extending life span. Abbreviations : 16S rRNA : 16S ribosomal RNA; MAGs : Metagenome-assembled genomes; ASVs : Amplicon sequence variants; DNA : Deoxyribonucleic acid; FDR : False discovery rate: KEGG : Kyoto Encyclopedia of Genes and Genomes; PCoA : Principal coordinates analysis; PCR : Polymerase chain reaction; PICRUSt : Phylogenetic Investigation of Communities by Reconstruction of Unobserved States; Aβ : Amyloid-β (Aβ); BDNF : Brain-derived neurotrophic factor

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Section: Discussionmentioning

confidence: 99%

The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function

et al. 2022

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“…Emphasizing the importance of mineral nutrients for healthy brain aging, Key et al [28] stated in their results that a nutrient regime containing macro-and micronutrients softens the effect of brain structure on cognitive function in old age and supports the effectiveness of interdisciplinary methods in nutritional cognitive neuroscience for a healthy brain. In the article of Çetin et al [64], different researchers reported…”

Section: Tablementioning

confidence: 98%

“…According to the Bourre [63] and Key et al [28], nutrients such as vitamins, minerals, and amino acids play a crucial role in ensuring proper brain function. Vitamins protect against inflammation and reactive oxidative species.…”

Section: Tablementioning

confidence: 99%

“…These deficiencies may affect cognitive performance, especially in vulnerable groups such as the elderly and those exposed to occupational pressures and difficult living conditions. Key et al [28] noted that dietary science is increasingly recognized for its ability to prevent and support disease prevention and new technologies and therapies to improve modern medical practice. Researchers noted that dietary studies help discover specific dietary patterns that promote healthy brain aging and moderate the involvement of nervous systems known to facilitate cognitive performance in later life [28].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Different Substrates with Chemical and Organic Fertilizer Applications on Vitamins, Mineral, and Amino Acid Content of Grape Berries from Soilless Culture

Tangolar¹,

Tangolar²,

Turan³

et al. 2023

Recent Research and Advances in Soilless Culture

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Due to its advantages, soilless cultivation has been used for both early- and late-maturing grape varieties. High nutritional and energy value is one of the strongest features that make the grape an effective component of agriculture and the human diet. Therefore, it was thought that it would be useful to determine the nutrient content of the berries in a soilless culture study carried out on the Early Cardinal grape variety. One-year-old vines were trained to a guyot system and grown in 32-liter plastic pots containing four different solid growing media, namely, zeolite, cocopeat, and zeolite+cocopeat (Z + C) (1:1 and 1:2, v:v). A total of three different nutrient solutions (Hoagland, Hoagland A (adapted to the vine) and organic liquid worm fertilizer (OLWF)) were applied to the plants. Grapevines were given different solutions starting from the bud burst. Z + C (1:1) substrate mixture giving the highest values of 14 amino acids, vitamins, and most macro- and microelements. Hoagland and Modified Hoagland nutrient solutions mostly gave higher values than OLWF for the properties studied. In general, it was observed that there were no significant losses in terms of mineral, vitamin, and amino acid composition in soilless grape cultivation.

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“…Aspartic acid regulates the metabolic function of the brain and nerves, and its substituted derivatives can be used as drugs for the treatment of neurological diseases and brain diseases. Aspartic acid can be also used to treat heart disease, liver disease, and hypertension because it has the function of preventing and treating fatigue. − As a supplement for the nerve center and cerebral cortex, glutamic acid has a certain effect on the treatment of concussion or nerve damage, and epilepsy, and for children with mental retardation. − Therefore, exploiting a quick and efficient chemical approach for recognizing and sensing of two kinds of acidic amino acids is very important. However, it is rare that the homochiral coordination polymer is used as chemical probe to detect acidic amino acids …”

Section: Introductionmentioning

confidence: 99%

Homochiral Helical Coordination Architectures Built from Biphenyl-Based Amino Acid Derivatives: Structural Diversity Tuned by Varying Conformation and Configuration of N-Donor Ligands, Sensing of Acidic Amino Acids, and Photoluminescence Properties

Guo

Wang

et al. 2020

Crystal Growth & Design

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Self-assembly of divalent metal ions and designed amino acid derivatives, 4,4′-biphenyl-bis[carbonyl-N-(alanine)] (H 2 BPBAla) and 4,4′-biphenylbis [carbonyl-N-(proline)] (H 2 BPBPro), as well as ancillary ligands, 1,2-bis(4pyridyl)ethane (bpea) and N,N′-bis(4-pyridyl)isophthalamide (bpipa), generated seven homochiral coordination polymers [Cu 2 (BPBAla) 7). All compounds contain different chiral metal-amino acid derivative helixes, which are tuned by varied conformation and configuration of N-donor ligands. 1 exhibits left-handed, doublestranded Cu-BPBAla helical chains tuned by the trans-conformation bpea ligand, whereas isostructural 2 and 3 exhibit right-handed, single-stranded Co/Ni-BPBAla helical chains tuned by the gauche-conformation bpea ligand. In the absence of an ancillary ligand, 4 displays a two-dimensional (2D) Cd-BPBAla layered network made up of left-handed, single-stranded (−Cd-O−) n helical chains and right-handed, double-stranded Cd-BPBPro-fragment helical chains. When H 2 BPBPro replaces H 2 BPBAla, 5 becomes a three-dimensional (3D) framework composed of right-handed, single-stranded Cu-BPBPro helical chains and transconformation bpea ligand. 6 and 7 are isostructural 3D frameworks and constructed by the coalition of left-handed, single-stranded Cd/Zn-BPBPro and Cd/Zn-bpipa helical chains, and there is an angle of 92.28°between the two Cd/Zn-BPBPro helical chains. The photoluminescence spectra of 4, 6, and 7 reveal the corresponding emission of ligands. More significantly, 6 and 7 can effectively detect the natural acidic amino acids by the enhancement of UV absorption intensity.

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Essential Amino Acids, Vitamins, and Minerals Moderate the Relationship between the Right Frontal Pole and Measures of Memory

Cited by 11 publications

References 42 publications

The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function

The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function

The Effects of Different Substrates with Chemical and Organic Fertilizer Applications on Vitamins, Mineral, and Amino Acid Content of Grape Berries from Soilless Culture

Homochiral Helical Coordination Architectures Built from Biphenyl-Based Amino Acid Derivatives: Structural Diversity Tuned by Varying Conformation and Configuration of N-Donor Ligands, Sensing of Acidic Amino Acids, and Photoluminescence Properties

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