“…This notwithstanding, Baillarger re-shuffled Esquirol's classification [Lypemania (Melancholia); Monomania; Mania; Dementia; Imbecility)] into Monomania (madness with partial lesion of the intellect); Melancholia (general lesion of the intellectual and moral functions) and Mania (general lesion). Berrios [19 ] nevertheless writes that 'it could be speculated that this change was responsible for the development of the view that mania and melancholia were expressions of a primary ''lesion of mood'', that is, of the view that was to come via Kraepelin into the 20th century' ( [19 ] p. 360). Berrios ([19 ] p. 359) points out how 'preconceived taxonomic criteria determine, in a ''top-to-bottom fashion'', the very ''clinical'' boundaries of mental disorders.…”