ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

Kim, Sup; Lee, June-Young; Shin, Seul Gi; Kim, Jin‐Kyung; Silwal, Prashanta; Kim, Young Jae; Shin, Na-Ri; Kim, Pil Soo; Won, Minho; Lee, Sang‐Hee; Kim, Soo Yeon; Sasai, Miwa; Yamamoto, Masahiro; Bae, Jin-Woo; Jo, Eun‐Kyeong

doi:10.1080/15548627.2020.1847460

Cited by 44 publications

(33 citation statements)

References 90 publications

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“…In addition, EMS is an oestrogen‐dependent disease. Previous studies have shown that GM is affected by oestrogen and can significantly affect the level of oestrogen 30,31 . Therefore, the occurrence and the development of EMS may be affected by GM.…”

Section: Discussionmentioning

confidence: 99%

Alpha‐linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis

Ding

Zhao

et al. 2021

American J Rep Immunol

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Problem This study aims to investigate the effects of alpha‐linolenic acid (ALA) on the gut microbiota (GM) and the abdominal environment in mice with endometriosis (EMS). Methods The effects of faecal microbiota transplantation (FMT) from EMS mice on mice treated with antibiotic cocktail were conducted. The 16S rRNA sequencing and PICRUSt software were used to detect the structure and function of GM respectively. The protein levels of Claudin 4 and ZO‐2 in the intestinal wall were detected using the western blotting. The level of LPS in the abdominal cavity was detected using enzyme‐linked immunosorbent assay (ELISA). The content of macrophages in the abdominal cavity was detected using flow cytometry. Results The exogenous supplementation of ALA could restore the abundance of Firmicutes and Bacteroidota in EMS mice. After the ALA treatment, the abundance of 125 functional pathways and 50 abnormal enzymes related to GM in EMS mice was significantly improved (p < .05). The expression of the ZO‐2 protein in the intestinal wall was decreased, and the level of LPS in the abdominal cavity was significantly increased after FMT from EMS mice (p < .05). ALA could increase the expression of the ZO‐2 protein in the intestinal wall of EMS mice, reduce the level of LPS in the abdominal cavity (p < .05) and reduce the aggregation of peritoneal macrophages (p < .05). Conclusion Alpha‐linolenic acid can improve the GM, intestinal wall barrier and abdominal inflammatory environment and reduce the level of LPS in mice with EMS.

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Section: Discussionmentioning

confidence: 99%

Alpha‐linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis

Ding

Zhao

et al. 2021

American J Rep Immunol

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“…Defective autophagy was suggested to have a strong impact on IBD pathogenesis, via disruption of intestinal barrier integrity, affecting GM composition and amplifying intestinal inflammation (Larabi et al, 2020). Furthermore, GM and autophagy influence each other and their interplay help to maintain intestinal homeostasis (Kim et al, 2020;Larabi et al, 2020). Until now, no study has reported the function of interplay of GM with autophagy during PD pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies demonstrated GM is closely linked to intestinal pathology and inflammation through its interplay with autophagy in mechanism studies of colon cancer and inflammatory bowel disease (IBD). GM dysbiosis could regulate autophagy (Kim et al, 2020) and autophagy has a role in the control of GM compositions (Larabi et al, 2020). Many clinical studies observed GM dysbiosis in PD patients, which plays key roles in aggravating PD through the promotion of inflammatory cascades or oxidative stress in the brain via short chain fatty acids (SCFA)-production or a lipopolysaccharide (LPS)-mediated mechanism (Breen et al, 2019;Roy Sarkar and Banerjee, 2019;Yang et al, 2019;Pascale et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson’s Disease Mice Model

Liu

Wang

et al. 2021

Front. Aging Neurosci.

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The role of gut-brain axis in the pathogenesis of Parkinson’s disease (PD) have become a research hotspot, appropriate animal model to study gut-brain axis in PD is yet to be confirmed. Our study employed a classical PD mice model achieved by chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) injection to study concurrent changes of dopaminergic neurons in the midbrain and the colon of mice. Our results showed such a PD model exhibited apparent locomotor deficits but not gastrointestinal dysfunction. Tyrosine hydroxylase expressions and dopamine content reduced greatly in the substantia nigra pars compacta (SNpc) or striatum, but increased in the colon of PD mice. Mechanism investigation indicated autophagy activity and apoptosis were stimulated in the SNpc, but inhibited in the colon of PD mice. Interplay of gut microbiota (GM) and autophagy in response to chronic MPTP injection led to GM dysbiosis and defective autophagy in mice colon. Meanwhile, fecal short chain fatty acids (SCFAs), acetate and propionate in particular, declined greatly in PD mice, which could be attributed to the decreased bacteria abundance of phylum Bacteroidetes, but increased abundance of phylum Firmicutes. GM dysbiosis derived fecal SCFAs might be one of the mediators of downregulated autophagy in the colon of PD mice. In conclusion, colonic dopaminergic neurons changed in the opposition direction with those in the midbrain via GM dysbiosis-mediated autophagy inhibition followed by suppressed apoptosis in response to chronic MPTP injection. Such a chronic PD mice model might not be an ideal model to study role of gut-brain axis in PD progression.

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“…Q-PCR and ERIC-PCR results indicated that the small intestinal microbial diversity of Tianfu Meat Goose was higher after overfeeding. The increasing intestinal microbial diversity increased intestinal homeostasis and resistance to pathogens ( Mountzouris et al., 2015 ; Kim et al., 2020 ; Rodrigues et al., 2020 ). Thereby, intestinal microflora stabilization of Tianfu Meat Goose was higher than that of Gang Goose under force-feeding.…”

Section: Discussionmentioning

confidence: 99%

Comparison of overfeeding effects on gut physiology and microbiota in two goose breeds

Wei

et al. 2021

Poultry Science

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To have a better understanding of how the “gut–liver axis” mediates the lipid deposition in the liver, a comparison of overfeeding influence on intestine physiology and microbiota between Gang Goose and Tianfu Meat Goose was performed in this study. After force-feeding, compared with Gang Goose, Tianfu Meat Goose had better fat storage capacity in liver (397.94 vs. 166.54 for foie gras weight (g), P < 0.05; 6.37 vs. 2.92% for the ratio of liver to body, P < 0.05; 60.01 vs. 46.64% for fat content, P < 0.05) and the less subcutaneous adipose tissue weight (1240.96 g vs. 1440.46 g, P < 0.05). After force-feeding, the digestion–absorption capacity of Tianfu Meat Goose was higher than that of Gang Goose (5.56 vs. 3.64 and 4.63 vs. 3.68 for the ratio of villus height to crypt depth in duodenum and ileum, respectively, P < 0.05; 1394.96 vs. 782.59 and 1314.76 vs. 766.17 for the invertase activity (U/mg-prot), in duodenum and ileum, respectively, P < 0.05; 6038.36 vs. 3088.29 and 4645.29 vs. 3927.61 for the activity of maltase (U/mg-prot), in duodenum and ileum, respectively, P < 0.05). Force-feeding decreased the gene expression of Escherichia coli in the ileum of Tianfu Meat Goose; force-feeding increased the number of gut microbiota Enterobacterial Repetitive Intergenic Consensus-Polymerase Chain Reaction band in Tianfu Meat Goose and decreased the number in Gang Goose. In conclusion, compared with Gang Goose, the lipid deposition in the liver and the intestine digestion–absorption capacity and stability were higher in Tianfu Meat Goose. Thereby, Tianfu Meat Goose is the better breed for foie gras production for prolonged force-feeding; Gang Goose possesses better fat storage capacity in subcutaneous adipose tissue. However, Gang Goose has lower gut stability responding to force-feeding, so Gang Goose is suited to force-feeding in a short time to gain the body weight and subcutaneous fat as an overfed duck for roast duck.

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ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

Cited by 44 publications

References 90 publications

Alpha‐linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis

Alpha‐linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis

Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson’s Disease Mice Model

Comparison of overfeeding effects on gut physiology and microbiota in two goose breeds

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