Esplenomegalias em cães: estudo retrospectivo e análise imunohistoquímica do Fator de Crescimento Endotelial Vascular (VEGF)

Abstract

New blood vessel formation is a fundamental event in the process of tumor growth and metastatic dissemination, being the vascular endothelial growth factor (VEGF) one of the key regulators of this process. The aim of this study was evaluate the VEGF immunohistochemical expression in splenic hemangiosarcomas and hemangiomas, and review the prevalence of canine splenic disorders through retrospective analysis of histological diagnosis after splenectomy. The results were confronted with laboratory findings, clinical signs and presence of cardiac arrhythmia and hemoperitoneum. A hundred nine dogs were included in the retrospective study