Esophagogastrointestinal leiomyo(sarco)mas

Grigg, Erika

doi:10.1016/0002-9343(61)90143-7

Cited by 24 publications

(2 citation statements)

References 75 publications

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“…The relative prevalence of benign versus malignant smooth muscle tumors has indicated that leiomyomas (LMs) are two to three times more common than LMS in the small intestine [9,10]. Only 44% to 50% of LMs are symptomatic, the remainder are usually identified at autopsy or during unrelated surgery [11,12].…”

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confidence: 99%

Tumors of the Small Intestine

2000

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This collective review includes all available case reports and series of smooth muscle (stromal) tumors of the small intestine in the world literature from 1881 to 1996. We identified 1074 patients with leiomyoma (LM) and 1689 with leiomyosarcoma (LMS). Our purpose was to update our previous review, which encompassed case reports and series from 1881 to 1959, which included 350 LMs and 257 LMSs. The peak incidence of smooth muscle tumors in the small intestine in both male and female patients was between the ages of 50 and 59. Most commonly, the presenting complaint was gastrointestinal bleeding. Computed tomography was found to detect LM and LMS most successfully and had the additional advantage of locating metastatic disease. The jejunum contained the highest numbers of smooth muscle tumors, followed by the ileum and then the duodenum, with malignant lesions in all locations typically attaining larger diameters than benign tumors. The overall rate of metastatic spread of LMS ranged from 24% to 50%, with the liver being most commonly involved. Unlike other sarcomas, both hematogenous and lymphatic spread were common. The 5-year survival of 705 patients with LMS from 22 series was 27. 8%. For both benign and malignant smooth muscle tumors of the small intestine, surgery remains the treatment of choice, with little efficacy reported for irradiation, chemotherapy, or both.

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Tumors of the Small Intestine

2000

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“…Aetio1ogy.-These tumours may arise from any of the unstriped duodenal muscle-fibres which form the muscularis mucosae, the longitudinal or the circular muscle coats, from isolated scattered muscle-fibres in the subserosa, or perhaps from blood-vessel walls (Starr and Dockerty, 1955;Grigg, 1961). It is probable that they may arise de 12000, though some authors believe that they may originate in benign leiomyomas (Weinstein and Roberts, 1953;Dodds and Beahrs, 1963)~ from embryonic cell rests (Lie and Sinclair, 1966), from a duodenal diverticulum, or even from the mesentery (Skandalakis and Gray, 1962).…”

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Leiomyosarcoma of the duodenum

McBrien¹,

Jarrett²

1971

Journal of British Surgery

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SUMMARYThree cases of leiomyosarcoma of the duodenum are reported. T h e literature is reviewed, and the clinical, diagnostic, and pathological features of this tumour are described. Wide surgical excision has proved to be the most effective treatment.LEIOMYOSARCOMA of the duodenum is an uncommon malignant tumour and is seldom encountered more than once or twice in the working life of any surgeon.I t receives brief mention in a few standard surgicalWe recently encountered a case in clinical practice and were able to find 2 others in the records of St. Peter's Hospital, Chertsey, from 1952 to 1970 CASE REPORTS Case 1.4vh-s. M. M., a housewife aged 53 years, was admitted to hospital in February, 1969. For a month she had felt faint and giddy and 3 days prior to admission had begun to pass melaena stools. She suffered from rheumatoid arthritis and had been treated with aspirin and prednisone for 9 years.On admission she was found to be anaemic (haemog!obin 5.2 g. per IOO ml.), but had no other abnormal signs.A blood transfusion was given but the melaena continued. A barium meal (Fig. I) showed an unusual 'diverticulum' of the third part of the duodenum, with an irregularly narrowed and possibly neoplastic neck. Atonic double-contrast duodenography (Fig. 2) reinforced the suspicion of malignancy and suggested a mass in the duodenal wall in relation to the ' diverticulum'.As the bleeding continued, laparotomy was performed. A large mobile tumour was found in the third part of the duodenum. No other abnormality was found. The third part of the duodenum containing the tumour was carefully mobilized from the pancreas and adjacent vessels, was resected, and an end-to-end anastomosis was performed. The abdomen was closed with drainage. The patient recovered uneventfully and went home on the tenth postoperative day. textbooks, and the majority of the recorded cases Macroscopic examination of the specimen (Fig. 3) in the literature were neither diagnosed preoperarevealed a tumour, 9 X 5 x 2 cm., in the wall of the tively nor recognized at laparotomy. T h e first case duodenum, the lumen. The was repofled by salis in 1920, and only 28 serosa was not involved, but the mucosa was ulcerated over an area 5 cm. in diameter (Fig. 4). MicroscopicOthers had been recorded before I9.53. Since then examination (Figs. 5, 6) showed a cellular, spindle-celled the lesion has been more frequently described. tumour arising in the smooth muscle of the duodenal wall; occasional mitoses were seen. The diagnosis was leiomyosarcoma (Dr. A. C. Cornsell).The patient is alive and in good health I year after her operation.

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Massive Leiomyoblastoma of the Stomach

Wolf¹

1968

Arch Surg

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Esophagogastrointestinal leiomyo(sarco)mas

Cited by 24 publications

References 75 publications

Tumors of the Small Intestine

Tumors of the Small Intestine

Leiomyosarcoma of the duodenum

Massive Leiomyoblastoma of the Stomach

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