Esophagogastric junction morphology assessment by high resolution manometry in obese patients candidate to bariatric surgery

Tolone, Salvatore; Savarino, Edoardo; Bortoli, Nicola de; Frazzoni, Marzio; Furnari, Manuele; D’Alessandro, Antonio; Ruggiero, Roberto; Docimo, Giovanni; Brusciano, Luigi; Gili, Simona; Pirozzi, Raffaele; Parisi, Simona; Colella, C.; Bondanese, Maria Chiara; Pascotto, Beniamino; Buonomo, Nunzio Mattia; Savarino, Vincenzo; Docimo, Ludovico

doi:10.1016/j.ijsu.2015.12.047

Cited by 25 publications

(19 citation statements)

References 28 publications

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“…These results were also confirmed by two large case series from Italy that compared antireflux surgical outcome in patients younger or older than 65 years[19,20]. Overweight and obesity are associated with increased intraabdominal pressure, presence of hiatal hernia, increased frequency of transient sphincter relaxation , diminished lower esophageal sphincter (LES) pressure, and and impaired gastric emptying, thus increasing esophageal acid exposure time (AET) and total number of reflux (TNR), which have a clear role in GERD and promoting symptoms[21,22]. Recently, Luketina et al[23] retrospectively evaluated antireflux surgical outcomes in obese patients compared to normal weight GERD patients.…”

Section: Demographics Factors (Gender Age Obesity Comorbidities)mentioning

confidence: 99%

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

Tolone

Gualtieri

Savarino

et al. 2016

WJGS

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Gastroesophageal reflux disease (GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors (PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD. Outcomes described in current literature following laparoscopic fundoplication indicate that it is highly effective for treatment of GERD; early clinical studies demonstrate relief of symptoms in approximately 85%-90% of patients. However it is still unclear which factors, clinical or instrumental, are able to predict a good outcome after surgery. Virtually all demographic, esophagogastric junction anatomic conditions, as well as instrumental (such as presence of esophagitis at endoscopy, or motility patterns determined by esophageal high resolution manometry or reflux patterns determined by means of pH/impedance-pH monitoring) and clinical features (such as typical or atypical symptoms presence) of patients undergoing laparoscopic fundoplication for GERD can be factors associated with symptomatic relief. With this in mind, we sought to review studies that identified the factors that predict outcome after laparoscopic total fundoplication.

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Section: Demographics Factors (Gender Age Obesity Comorbidities)mentioning

confidence: 99%

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

Tolone

Gualtieri

Savarino

et al. 2016

WJGS

Self Cite

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“…In a subsequent study, Tolone et al reviewed data on 138 obese subjects with or without symptoms. 11 Compared to nonobese patients, obese patients demonstrated more frequent hiatal hernia, lower LES resting pressure, and lower distal contractile integral values. Furthermore, they had increased incidence of ineffective esophageal motility (weak and failed) and a low rate of hypercontractile esophagus and premature contractions.…”

Section: Obesity and Esophageal Functionmentioning

confidence: 90%

“…In a subsequent study, Tolone et al . reviewed data on 138 obese subjects with or without symptoms . Compared to nonobese patients, obese patients demonstrated more frequent hiatal hernia, lower LES resting pressure, and lower distal contractile integral values.…”

Section: Obesity and Esophageal Functionmentioning

confidence: 99%

The impact of bariatric surgery on esophageal function

Tolone

Savarino

Yates

2016

Annals of the New York Academy of Sciences

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Obesity is a worldwide epidemic. There is increasing evidence that obesity is associated with benign gastroesophageal disease, including gastroesophageal reflux disease (GERD) and esophageal dysmotility. Bariatric surgery-including sleeve gastrectomy, gastric bypass, and adjustable gastric band placement-can effectively result in weight loss and control of obesity-related conditions, including GERD. However, there is increasing evidence that bariatric surgery itself can have a deleterious effect on esophageal function. In this review, we address the effect of obesity and bariatric surgery on esophageal dysfunction.

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“…En realidad, la manometría de alta resolución puede proporcionar información precisa sobre la morfología del EEI después de la manga y demostrar que la separación creciente entre EEI y crura diafragmática puede causar un aumento gradual y significativo en el reflujo [22][23][24][25] .…”

Section: Estudios Manométricos Y Monitoreo De Ph áCido Intraesofágicounclassified

Consecuencias fisiopatológicas y anatómicas posgastrectomía vertical tubular como posibles causas de enfermedad por reflujo gastroesofágico

Braghetto

2018

Rev Chil Cir

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Esophagogastric junction morphology assessment by high resolution manometry in obese patients candidate to bariatric surgery

Cited by 25 publications

References 28 publications

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

The impact of bariatric surgery on esophageal function

Consecuencias fisiopatológicas y anatómicas posgastrectomía vertical tubular como posibles causas de enfermedad por reflujo gastroesofágico

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