Esophagogastric junction adenocarcinoma shares characteristics with gastric adenocarcinoma: Literature review and retrospective multicenter cohort study

Imamura, Yu; Watanabe, Masayuki; Oki, Eiji; Morita, Masaru; Baba, Hideo

doi:10.1002/ags3.12406

Cited by 33 publications

(37 citation statements)

References 65 publications

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“…Due to its location between the esophagus and stomach, the staging of AEJ as gastric or esophageal carcinoma is controversial. 14 Siewert and Stein defined AEJ as a tumor with an epicenter < 5 cm from the anatomic location of the EJ. 15 Traditionally, cardia cancer refers to a cancer found 2 cm proximal or distal to the junction.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics and Survival Predictions for Adenocarcinoma of the Esophagogastric Junction: A SEER Population-Based Retrospective Study

Liu¹,

Jiang²,

Yue³

et al. 2021

IJGM

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Objective Adenocarcinoma of the esophagogastric junction (AEJ) is a relatively rare malignancy in Western countries whose specific clinicopathological characteristics and associated prognosis have not been comprehensively described. Methods Data on patients with AEJ between 2005 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were extracted, evaluated, and compared with patients with gastric cancer (GC) in general. Overall survival (OS) was evaluated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards regression model to identify risk factors predictive for OS, and the results were used to construct a nomogram to predict 1-, 3-, and 5-year OS among patients with AEJ. Results A total of 8013 patients diagnosed with AEJ were identified from the records of 30,179 patients with GC. The mean age was 65.4 (SD = 12.0) years, 79.5% were men, 87.2% were Caucasian, 91.5% were moderately-to-poorly differentiated, 34.4% had AJCC stage I AEJ, and 28.8% had stage IV. The median OS was 18 months, and the 5-year OS was 25.8% (95% CI: 24.8–26.8%). Fewer patients with AEJ had undergone surgical resection, fewer had T+ and N+ (N2~N3) disease ( P < 0.001), and fewer had distant metastases compared to the patients with GC ( P < 0.05). In the univariate and multivariate analyses, age, race, summary stage, N stage, M stage, and surgery were identified as independent risk factors. The nomogram had a calibration index of 0.726. Conclusion AEJ was found to have distinct clinicopathological characteristics. Age, race, summary stage, N stage, M stage, and surgery were independently associated with OS. The nomogram accurately predicted 1-, 3-, and 5-year OS rates.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics and Survival Predictions for Adenocarcinoma of the Esophagogastric Junction: A SEER Population-Based Retrospective Study

Liu¹,

Jiang²,

Yue³

et al. 2021

IJGM

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“…Although gastric cancer that is not associated with H. pylori infection is extremely rare, gastric is cancer associated with autoimmune gastritis, gastric cancer due to CDH1 gene mutation, fundic gland-type cancer, signet ring cell carcinoma, and cardia cancer are known [ 45 ]. Cardia cancer is often discovered at an advanced stage; thus, particular attention should be paid to it [ 46 ]. Moreover, the main risk factors of cardia cancer, which include gastroesophageal reflux disease and obesity, are different from those of gastric cancer associated with H. pylori [ 47 ].…”

Section: Gastric Cancer In Japanmentioning

confidence: 99%

Gastric Cancer Screening in Japan: A Narrative Review

Yashima

Shabana

Kurumi

et al. 2022

JCM

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Gastric cancer is the second leading cause of cancer incidence in Japan, although gastric cancer mortality has decreased over the past few decades. This decrease is attributed to a decline in the prevalence of H. pylori infection. Radiographic examination has long been performed as the only method of gastric screening with evidence of reduction in mortality in the past. The revised 2014 Japanese Guidelines for Gastric Cancer Screening approved gastric endoscopy for use in population-based screening, together with radiography. While endoscopic gastric cancer screening has begun, there are some problems associated with its implementation, including endoscopic capacity, equal access, and cost-effectiveness. As H. pylori infection and atrophic gastritis are well-known risk factors for gastric cancer, a different screening method might be considered, depending on its association with the individual’s background and gastric cancer risk. In this review, we summarize the current status and problems of gastric cancer screening in Japan. We also introduce and discuss the results of gastric cancer screening using H. pylori infection status in Hoki-cho, Tottori prefecture. Further, we review risk stratification as a system for improving gastric cancer screening in the future.

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“…Several population-based studies [1-5, 24] from Western countries have reported a rapid increase in the incidence of not only esophageal adenocarcinoma but also GEJ adenocarcinoma. Interestingly, the incidence of GEJ adenocarcinoma increased at a much slower rate than that of esophageal adenocarcinoma [8, 9]. These 2 types of adenocarcinomas are sometimes confused because they share common risk factors [2-5].…”

Section: Epidemiology Of Esophageal Adenocarcinoma and Gej Adenocarcinoma In Asian Countriesmentioning

confidence: 99%

Epidemiological Review of Gastroesophageal Junction Adenocarcinoma in Asian Countries

2021

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Background: Similar trends in the prevalence of gastroesophageal reflux disease (GERD), obesity, and Helicobacter pylori infection have been observed in Asian and Western countries despite their time differences. However, it is unclear whether the prevalence of gastroesophageal junction adenocarcinomas in Asian countries is increasing. In this review, we discuss the epidemiological trends of gastroesophageal junction adenocarcinoma in Asian countries. Summary: The prevalence of GERD is increasing in Asian countries, but most cases are considered mild. Obesity is a serious problem worldwide, but it is considered less serious in Asia than in Western countries. In Asian countries where gastric cancer is common, both cardiac and noncardiac cancers are associated with high rates of H. pylori infection, which is considered a carcinogenic risk factor for both sites of cancer. The widespread use of H. pylori eradication therapy for chronic gastritis in several Asian countries has not directly led to an increased prevalence of esophageal adenocarcinoma. One of the originating sites of junctional adenocarcinoma in most Asian countries is Barrett’s esophagus, with short-segment Barrett’s esophagus having much lower carcinogenicity than long-segment Barrett’s esophagus. Key Messages: Considering the future trends of several risk factors for gastroesophageal junction adenocarcinoma in Asian countries, it is likely that the incidence of gastroesophageal junction adenocarcinoma will gradually increase, but not at a rate that exceeds that of squamous cell carcinoma, as in Western countries.

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Esophagogastric junction adenocarcinoma shares characteristics with gastric adenocarcinoma: Literature review and retrospective multicenter cohort study

Cited by 33 publications

References 65 publications

Clinicopathological Characteristics and Survival Predictions for Adenocarcinoma of the Esophagogastric Junction: A SEER Population-Based Retrospective Study

Clinicopathological Characteristics and Survival Predictions for Adenocarcinoma of the Esophagogastric Junction: A SEER Population-Based Retrospective Study

Gastric Cancer Screening in Japan: A Narrative Review

Epidemiological Review of Gastroesophageal Junction Adenocarcinoma in Asian Countries

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