Esophageal undifferentiated carcinoma displaying marked chondroid differentiation at metastatic foci

Yokoo, Hideaki; Arai, Hanako; Isoda, Koji; Nakazato, Yoichi; Nakayama, Yuko; Suzuki, Yoshihiko; Hatakeyama, Setsuko

doi:10.1046/j.1440-1827.1999.00873.x

Cited by 12 publications

(11 citation statements)

References 14 publications

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“…Foci of cartilaginous metaplasia have been found in some human carcinomas, 13 but none of the affected fish examined in this study had any gross or histologic evidence of primary neoplastic disease.…”

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confidence: 56%

Visceral Nodular Cartilaginous Metaplasia in Rockfishes (Sebastes Spp.) in the Eastern North Pacific Ocean

et al. 2002

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Abstract. Multiple, discrete, nodular foci of cartilaginous metaplasia were found in the spleens and kidneys of rockfishes taken from the northeastern Pacific Ocean during a survey to determine the incidence and the nature of diseases in these animals. These nodules sometimes occurred in association with granulomatous inflammation and distinct granulomas. Many of these fish were infected by Ichythophonus spp. or acid-fact bacteria (presumably Mycobacteria spp.). Some of the metaplastic foci contained encapsulated accumulations of eosinophilic vesicles and basophilic granular debris, described by other authors as ''cysts of unknown etiology,'' which have been observed at different sites in a variety of temperate and tropical fish species.

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confidence: 56%

Visceral Nodular Cartilaginous Metaplasia in Rockfishes (Sebastes Spp.) in the Eastern North Pacific Ocean

et al. 2002

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“…This type of carcinoma is composed of overt carcinoma with direct transition to a cartilaginous and/or osseous stromal matrix without an intervening spindle cell zone or osteoclastic cells 9 . In carcinoma with stromal metaplasia arising from the breast or esophagus, previous reports showed that both carcinomatous and cartilaginous components showed common immunohistochemical features and cytological atypia, so it was thought that both elements were derived from identical cells 9–11 …”

Section: Discussionmentioning

confidence: 99%

“…9 In carcinoma with stromal metaplasia arising from the breast or esophagus, previous reports showed that both carcinomatous and cartilaginous components showed common immunohistochemical features and cytological atypia, so it was thought that both elements were derived from identical cells. [9][10][11] On the other hand, in bladder tumors with stromal metaplasia, the bone and cartilage components are cytological benign. Previous reports hypothesized that urothelial epithelium had some cartilage-evoking activity.…”

Section: Discussionmentioning

confidence: 99%

Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report

Jokoji¹,

Tsuji²,

Tsujimoto³

et al. 2012

Pathology International

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Recently, a surgically resected case of intraductal tubulopapillary neoplasm (ITPN) with stromal osseous and cartilaginous metaplasia was encountered. A CT scan showed calcification at the tail of the pancreas two years before the operation. In the resected specimen, macroscopically, the main pancreatic duct was dilated and filled with a whitish solid mass without mucinous material. The tumor showed mainly a solid and papillary growth pattern. The tumor cells had no evidence of acinar differentiation. The tumor cells, at the tail of the pancreas, invaded focally to surrounding pancreatic parenchyma with stromal desmoplastic and fibrosclerotic reaction and also formed nodular stromal osseous and cartilaginous metaplasia. The tumor did not invade extrapancreatic tissue and showed no lymph node metastasis. As there were no signs of chronic calcifying pancreatitis, it is hypothesized that the metaplastic stroma was formed by a stromal reaction due to the tumor growth. It is thought, therefore, that the intraducal component of the tumor had existed at least for two years. This case suggests that ITPN is a relatively indolent tumor with a better prognosis than that of other types of invasive ductal adenocarcinoma of the pancreas.

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“…To our knowledge, there are six published reports on esophageal carcinoma characterized by a chondroid element. [1][2][3]5,8,9 Macroscopically, these six cases did not show a typical ulcerative type of esophageal carcinoma and exhibited polypoid growth. In contrast to the above six cases, the present case exhibited macroscopic features typical of esophageal carcinoma.…”

Section: Discussionmentioning

confidence: 94%

“…Furthermore, the p53 was immunopositive in the carcinomatous and chondroid areas in this case. 5 Alterations of the p53 gene may not be associated with chondroid differentiation in esophageal cancers.…”

Section: Discussionmentioning

confidence: 98%

Esophageal squamous cell carcinoma characterized by extensive chondroid differentiation

Sugai

Oikawa²,

Uesugi

et al. 2000

Pathology International

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A rare case of carcinoma characterized by extensive chondroid elements at a site of primary esophageal and metastatic lesion is reported. The patient was a 67-year-old man complaining of dysphagia due to an ulcerative lesion at the lower middle esophagus. He underwent irradiation treatment prior to surgery. Histologically, the tumor consisted of both carcinomatous and chondroid elements and had invaded deeply into the esophageal wall. The carcinomatous cells had gradually become chondroid cells embedded within an extensive extracellular matrix. In addition, the metastatic lesion showed findings similar to those of the primary lesion. Immunohistochemistry revealed that both carcinomatous and chondroid elements were immunostained with cytokeratin and epithelial membrane antigen, suggesting an epithelial nature to the chondroid cells. Conversely, only chondroid cells were positively stained for S-100 protein. Furthermore, bone morphogenetic proteins (BMP) were positive for chondroid cells and their surrounding carcinomatous cells. Given the apparent transition between carcinomatous and chondroid cells based on microscopy and immunohistochemical findings in the present case, we concluded that the chondroid cells were derived from carcinomatous cells. In addition, our findings suggest that BMP produced by carcinomatous cells lead to chondroid differentiation of the carcinoma cells.

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Esophageal undifferentiated carcinoma displaying marked chondroid differentiation at metastatic foci

Cited by 12 publications

References 14 publications

Visceral Nodular Cartilaginous Metaplasia in Rockfishes (Sebastes Spp.) in the Eastern North Pacific Ocean

Visceral Nodular Cartilaginous Metaplasia in Rockfishes (Sebastes Spp.) in the Eastern North Pacific Ocean

Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report

Esophageal squamous cell carcinoma characterized by extensive chondroid differentiation

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