Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review

Tominaga, Kentaro; Tsuchiya, Atsunori; Sato, Hiroki; Mizusawa, Takeshi; Morita, Shinichi; Ishii, Yui; Takeda, Nobutaka; Natsui, Kazuki; Kawata, Yuzo; Kimura, Naruhiro; Arao, Yoshihisa; Takahashi, Kazuya; Hayashi, Kazunao; Yokoyama, Junji; Terai, Shuji

doi:10.2169/internalmedicine.4437-20

Cited by 3 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first case of esophagitis was reported by Margoles et al [ 23 ] in 1961. The occurrence of esophagitis has been described more frequently in pediatric patients than in adult individuals[ 24 ]. However, the endoscopic and histologic characteristics are unspecified or nonspecific.…”

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

“…There are relatively few reports of esophageal ulcers associated with UC. Until now, there have been only 20 cases of esophageal ulcers (including ours) accompanied by UC[ 23 , 24 , 35 - 45 ]. The clinical characteristics of these patients are listed in Table 2 .…”

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

“…The clinical characteristics of these patients are listed in Table 2 . It is a punched-out ulcer and frequently seen in the middle to the lower esophagus[ 24 ]. According to the previous findings, esophageal ulcers were more commonly seen in the young individuals than in elderly individuals.…”

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

“…Moreover, immunosuppression such as cyclosporine, tacrolimus, or infliximab may be the treatment option for UGI inflammation[ 77 , 82 , 133 , 134 ] (Figure 5 ). For example, for individuals with UC-associated esophageal ulcers, intravenous prednisolone (50 mg/d or 60 mg/d) was administered, and some symptoms including chest pain, bloody stool, pain on swallowing, and diarrhea were improved within a couple of days[ 24 ]. For individuals with UGDL, particularly those presenting with mild symptoms, some drugs, such as sulfasalazine or mesalazine, could effectively relieve the symptoms[ 54 ], while for some individuals with severe UGDL, TNF antagonists, infliximab, or calcium antagonists might be more effective than sulfasalazine or steroid hormones[ 82 , 132 ].…”

Section: Therapy Of Ugi Lesionsmentioning

confidence: 99%

See 3 more Smart Citations

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Sun¹,

Zhang²,

Cheng³

et al. 2021

WJG

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. The colorectum is considered the chief target organ of UC, whereas upper gastrointestinal (UGI) tract manifestations are infrequent. Recently, emerging evidence has suggested that UC presents complications in esophageal, stomachic, and duodenal mucosal injuries. However, UC-related UGI tract manifestations are varied and frequently silenced or concealed. Moreover, the endoscopic and microscopic characteristics of UGI tract complicated with UC are nonspecific. Therefore, UGI involvement may be ignored by many clinicians. In addition, no standard criteria have been established for patients with UC who should undergo fibrogastroduodenoscopy. Furthermore, specific treatment recommendations may be needed for patients with UC-associated UGI lesions. Herein, we review the esophageal, gastric, and duodenal mucosal lesions of the UC-associated UGI tract, as well as the potential pathogenesis and therapy.

show abstract

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

Section: Therapy Of Ugi Lesionsmentioning

confidence: 99%

See 2 more Smart Citations

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Sun¹,

Zhang²,

Cheng³

et al. 2021

WJG

View full text Add to dashboard Cite

show abstract

A case of ulcerative colitis complicated with esophageal ulcer

et al. 2023

View full text Add to dashboard Cite

Enhanced Risk of Gastroesophageal Reflux Disease and Esophageal Complications in the Ulcerative Colitis Population

Wang,

Almetwali,

Wang

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Although heartburn and reflux are frequently reported in ulcerative colitis [UC], the correlation between UC and gastroesophageal reflux disease [GERD], and its complications, esophageal stricture and Barrett’s esophagus [BE], is not well understood. This study aims to examine the prevalence and associated risk of GERD and its complications within the UC population. Methods: We analyzed the National Inpatient Sample (NIS) dataset, consisting of 7,159,694 patients, comparing GERD patients with and without UC to those without GERD. We assessed the degree of colonic involvement in UC and the occurrence of esophageal complications. Bivariate analyses were conducted using the chi-squared test or Fisher exact test (two-tailed). Results: A higher prevalence of GERD (23.0% vs. 16.5%) and GERD phenotypes, such as non-erosive reflux disease (NERD) (22.3% vs. 16%) and erosive esophagitis (EE) (1.2% vs. 0.6%), was found in UC patients (p < 0.01), including pancolitis, proctitis, proctosigmoiditis, left-sided colitis, and indetermined UC (with undefined colonic involvement). UC patients were more likely to develop GERD (1.421), NERD (1.407), and EE (1.681) (p < 0.01). A higher prevalence of esophageal stricture (16.9 vs. 11.4 per 10,000 patients) and BE without dysplasia (94.5 vs. 39.3 per 10,000 patients) was found in UC (p < 0.05). The odds of developing BE without dysplasia were higher (1.892) in patients with UC (p < 0.01), including ulcerative pancolitis, proctitis, and indeterminate UC (OR of 1.657, 3.328, and 1.996, respectively) (p < 0.05). Conclusions: Our study demonstrates an increased risk of developing GERD and its complications in UC. This highlights the importance of vigilant monitoring and early intervention to minimize associated GERD-related risks in patients with UC.

show abstract

Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review

Cited by 3 publications

References 14 publications

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

A case of ulcerative colitis complicated with esophageal ulcer

Enhanced Risk of Gastroesophageal Reflux Disease and Esophageal Complications in the Ulcerative Colitis Population

Contact Info

Product

Resources

About