Esophageal transit and in vivo disintegration of branded risedronate sodium tablets and two generic formulations of alendronic acid tablets: A single-center, single-blind, six-period crossover study in healthy female subjects

Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis

“…It was shown, that the two generic formulations of alendronic acid tablets had significant slower transit times than compared with the branded risedronate (Actonel®) tablet tested [48]. The branded risedronate tablet had a significantly faster transit time than the two generic formulations of alendronate tested [48]. This is of importance for patients because delayed esophageal transit or disintegration of oral bisphosphonate tablets before they enter the stomach could cause iatrogenic complications.…”

“…Another trial evaluated and compared esophageal transit times and in vivo disintegration of one branded risedronate and two generic formulations of alendronic acid tablets [48], that are commercially available in Canada and the United Kingdom. It was shown, that the two generic formulations of alendronic acid tablets had significant slower transit times than compared with the branded risedronate (Actonel®) tablet tested [48].…”

Effects of anatomical position on esophageal transit time: A biomagnetic diagnostic technique

“…An advantage of this new application of the biomagnetic technique, implemented for the measurement of ETT, is that it demands little space and hardware, since all that is needed is a low-cost magnetometer. Therefore, this technique could be implemented for clinical assessment of esophageal disorders in general practice medicine, for gastroenterologists studying drug transit time [4,11] and in other specialties. Additionally, because of its low cost and non-invasiveness, this technique could be implemented in small clinical areas and hospitals.…”

“…A diagnosis of gastroesophageal reflux disease should include the presence of a pathological reflux in patients lacking another motility disorder or damage in the esophagus [2,3] . If this condition can not be met, then the evaluation should include the assessment of disintegration time of oral tablets before they enter the stomach [4] . Currently, diagnosis of gastroesophageal reflux diseases is made with endoscopy [5,6] , manometry [3] , imaging methods [7] , impedance [8] , scintigraphy [9] and other techniques [2,10] .…”

Nuclear Medicine in Nottingham: Antibodies, Gamma Probes and Drug Delivery

“…Much of this work has involved the study of tablet swallowing [ 16 ], gastrointestinal transit, the understanding of gastrointestinal physiology and the development of nuclear medicine imaging techniques for the study of the gastrointestinal tract Fig. 13.3 [ 17 ].…”