Esophageal squamous cell carcinoma with entirely intramural growth pattern

Abstract

Esophageal cancers are predominantly carcinomas, which are-due to their origin from the epithelial lining-visible by endoluminal view. We report in this study about the rare case of an esophageal squamous cell cancer with an unusual, entirely intramural growth pattern. The diagnosis could only be established postoperatively, because all preoperative biopsies had failed to demonstrate the tumor. The entirely intramural growth pattern of esophageal squamous cell cancer is an exceedingly rare variant, with only one previously reported case. Nevertheless, clinicians, radiologists, and pathologists should be aware of the potential existence of this condition, especially when clinical and imaging results suggest a malignant tumor that cannot be proven on biopsies. Surgical exploration must be considered under these circumstances.

Comparison of Endoscopic Submuscosal Implantation vs. Surgical Intramuscular Implantation of VX2 Fragments for Establishing a Rabbit Esophageal Tumor Model for Mimicking Human Esophageal Squamous Carcinoma

“…Our models are moderate-to-large-sized and were histologically proven to be the squamous cell type. The pathologic features that the models showed such as different degree of esophageal stricture, different tumor growth patterns, with/without invasion of adjacent tissues and regional/distant metastasis, are extremely similar to the clinicopathologic characteristics of human ESC [15]–[17]. The findings indicate that our animal models are reliable for mimicking the disease of human ESC.…”

Intramural carcinoma of the oesophagogastric junction

“…Another case was presented by Kishino et al ,6 showing an intramural, submucosal SCC with gastric metastasis. Previously von Rahden et al 7 presented a 5 cm measuring intramural SCC in the proximal oesophagus. The appearance of the tumour presented in this case differs from those published earlier, since the present SCC forms one solid mass with sharply demarcated margins, imitating a benign lesion such as leiomyoma or gastrointestinal stromal tumour.…”

Esophageal intramural squamous cell carcinomas presenting as subepithelial lesions removed by endoscopic submucosal dissection

“…Autopsy revealed carcinoma cells that might have arisen from an esophageal intramural squamous epithelial cyst. [ 9 ] In a 58-year-old man who underwent transhiatal esophagectomy, Von Rahden et al [ 10 ] reported that postoperative pathological examination suggested SCC with an intramural growth pattern. Schmitz et al reported a case of intramural SCC located at the gastroesophageal junction with features of a benign lesion.…”