Esophageal Sphincter Device for Gastroesophageal Reflux Disease

Ganz, Robert A.; Peters, Jeffrey H.; Horgan, Santiago; Bemelman, Willem A.; Dunst, Christy M.; Edmundowicz, Steven A.; Lipham, John C.; Luketich, James D.; Melvin, W. Scott; Oelschlager, Brant K.; Schlack-Haerer, Steven; Smith, C. Daniel; Smith, Christopher; Dunn, Dan; Taiganides, Paul A.

doi:10.1056/nejmoa1205544

Cited by 278 publications

(200 citation statements)

References 25 publications

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“…A recently published study showed encouraging results on acid exposure time and symptom improvement; however the high frequency of dysphagia requiring dilation is similar to that of conventional anti-reflux surgery and in a fraction of patients the device was removed because of SAE. 35 So far, no randomized controlled trials are available to fully assess the effect of the LINX-device.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, 18 patients have completed 3-month follow-up and 14 patients 6-month follow-up. Interim results showed a positive ef- fect on symptoms: GERD-HRQL median (IQR) score was 4 (2-11) at 3 months and 5 (4-9) at 6 months, respectively with P < 0.001 and P < 0.01 when compared to baseline score off PPI (31 [25][26][27][28][29][30][31][32][33][34][35][36][37]). Furthermore, acid exposure time decreased from 11.3% (9.0-15.5%) at baseline to 3.3% (2.5-9.1%) at 3 months and to 2.6% (1.8-5.4%) at 6 months (Fig.…”

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confidence: 99%

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Electrical Stimulation Therapy for Gastroesophageal Reflux Disease

Rinsma

Bouvy

Masclee

et al. 2014

J Neurogastroenterol Motil

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Electrical stimulation therapy (EST) of the lower esophageal sphincter is a relatively new technique for the treatment of gastroesophageal reflux disease (GERD) that may address the need of GERD patients, unsatisfied with acid suppressive medication and concerned with the potential risks of surgical fundoplication. In this paper we review available data about EST for GERD, including the development of the technique, implant procedure, safety and results from open-label trials. Two short-term temporary stimulation and long-term open-label human trials each were initiated to investigate the safety and efficacy of EST for the treatment of GERD and currently up to 2 years follow-up results are available. The results of EST are promising as the open-label studies have shown that EST is a safe technique with a significant improvement in both subjective outcomes of symptoms and objective outcomes of esophageal acid exposure in patients with GERD. However, long-term data from larger number of patients and a sham-controlled trial are required before EST can be conclusively advised as a viable treatment option for GERD patients.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Electrical Stimulation Therapy for Gastroesophageal Reflux Disease

Rinsma

Bouvy

Masclee

et al. 2014

J Neurogastroenterol Motil

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show abstract

“…It uses a bracelet of magnets encased in titanium, which is laparoscopically placed around the LES to create a 'magnetic sphincter'. In a study of 100 patients, normalization or improvement of distal esophageal pH at 1 year was observed in 64% of patients [34]. However, the LINX device was associated with a large number of device-related consequences including dysphagia in 68% of patients, requiring endoscopic dilatation in 19 patients and a 6% explant rate.…”

Section: Does Antireflux Surgery Carry An Advantage Over Medical Thermentioning

confidence: 99%

Strategies to improve outcomes in esophageal adenocarcinoma

Cowie

Noble

Underwood

2014

Expert Review of Anticancer Therapy

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“…New, less invasive surgical techniques may become established in the near future including laparoscopic insertion of an expandable titanium bead necklace (LINX) around the lower oesophagus sphincter to augment it 16 or the laparoscopic implantation of neurostimulator electrodes onto the lower oesophageal sphincter (EndoStim). 17 Both techniques have the advantages of being less invasive, reversible, with good side-effect profiles and initial good short-term results, but have limited long-term data.…”

Section: New Surgical Interventionsmentioning

confidence: 99%