Esophageal sarcomas

Perch, Steven J.; Soffen, Edward M.; Whittington, Richard; Brooks, John J.

doi:10.1002/jso.2930480311

Cited by 47 publications

(31 citation statements)

References 21 publications

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“…The recognition of SS in this unexpected site is probably often mistaken. Cytogenetic approach with fluorescence in situ hybridization (FISH) showing t(X; 18) translocation in SS is then crucial for allowing the diagnosis [21]. We report a case of primary SS of the esophagus, for which the diagnosis suspected histologically was made by cytogenetic studies.…”

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confidence: 99%

Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

et al. 2006

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Synovial sarcoma (SS) is an uncommon soft tissue tumor occurring mainly in the periarticular region of the extremities of young adults. In this report, we describe a very rare occurrence of primary SS of the esophagus in a 72-year-old woman. Histologically, the tumor demonstrated biphasic morphologic findings associated with poorly differentiated areas. Tumor cells expressed vimentin, epithelial (EMA, CK7, AE1/3), bcl-2 and neuroectodermal (CD56, CD57, CD99) antigens. Differential diagnose included esophageal sarcomatoid carcinoma. Cytogenetic analysis confirmed the diagnosis of SS by identifying t(X;18) translocation. The literature of this very uncommon entity of the esophagus is reviewed.

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confidence: 99%

Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

et al. 2006

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“…In general, enucleation of submucosal esophageal tumors seems reasonable, except for patients with suspected malignancy. In our case, the Ivor Lewis procedure was selected for complete resection of the tumor, as preoperative findings suggested leiomyosarcoma and complete resection would thus facilitate long-term survival [18,19]. In our review, one patient with a preoperative diagnosis of malignant schwannoma underwent esophagectomy.…”

Section: Discussionmentioning

confidence: 97%

Esophageal schwannoma treated by transthoracic esophagectomy: a case report

et al. 2004

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We report the case of a 72-year-old man with esophageal schwannoma who underwent the Ivor Lewis procedure. He suffered from dysphagia for 6 months. Esophagoscopy revealed a submucosal tumor bulging on the posterior wall 30 cm distant from the incisors. Endoscopic ultrasonography (EUS) revealed tumor located within the muscularis propria, the fourth layer of the esophageal wall. Upper gastrointestinal series showed an elevated lesion, 6 cm in diameter, on the posterior wall of the upper thoracic esophagus. These findings were suggestive of leiomyosarcoma. The area of esophagus including the tumor was resected using the Ivor Lewis procedure. The tumor was 5.5 ϫ 4.5 ϫ 4.5 cm in size, with a smooth surface that was elastic and firm. Histological examination revealed spindle-shaped cells with oval nuclei, and Antoni A and B types coexisted in the tumor tissue. Immunohistochemical studies yielded positive results for S-100 protein and negative results for CD34, desmin, and α-smooth muscle actin. A diagnosis of esophageal schwannoma was established. He was discharged from the hospital and has been doing well with no recurrence for 20 months after surgery.

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“…Radiotherapy may be used as adjuvant treatment, in cases where the risk of local recurrence is considered to be high, for example, in high-grade tumors, or when limb preservation is important. Limited surgery may be used to avoid amputation or the excessive loss of tissue, followed by radiotherapy in order to sterilize the remaining malignant cells (21)(22)(23)(24). It has been reported that completely resected lowgrade soft-tissue tumors do not require additional treatment (25).…”

Section: Discussionmentioning

confidence: 99%

“…However, due to its rarity, it is difficult to determine a pre-operative diagnosis and appropriate treatment strategy for cases of esophageal leiomyosarcoma. In previous years, leiomyosarcoma was not considered to be sensitive to radiation; therefore, radical radiotherapy treatment was rarely administered and a limited number of reports regarding the use of radiotherapy in the treatment of leiomyosarcoma exist in the literature (6,24,28). Although leiomyosarcoma has poor sensitivity to radiation, the tumor may be effectively controlled by increasing the radiation dose appropriately.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy treatment of large esophageal leiomyosarcoma: A case report

Wang³

et al. 2015

Oncology Letters

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Abstract. Leiomyosarcoma of the esophagus is a rare type of tumor, characterized by a malignant phenotype and smooth muscle histology. Previously, barium studies have been used to identify areas of luminal narrowing, expansile intraluminal masses or large intramural masses with ulceration or tracking. Furthermore, endoscopic biopsies appear to be associated with a high false negative rate, particularly in cases where the mucosa is intact. The optimal treatment strategy is surgical resection, while the role of adjuvant radiotherapy and chemotherapy is controversial. In addition, the prognosis of patients with leiomyosarcoma of the esophagus is improved compared with patients suffering from squamous esophageal cancer. The present study described the case of a 48-year-old woman who presented with dysphagia and was diagnosed with a large leiomyosarcoma of the esophagus. The patient was successfully treated with radiotherapy and remains disease-free two years after the completion of treatment. In addition, the present study conducted a review of the relevant literature, reporting previous cases of esophageal leiomyosarcoma and potential strategies for the management of this disease. IntroductionSquamous cell and adenocarcinoma are the two most common types of esophageal malignancies, whereas esophageal leiomyosarcoma is a rare type of tumor, accounting for <1% of all malignant esophageal tumors (1,2). Since the first case of esophageal leiomyosarcoma was reported in 1902 (3), >165 cases of esophageal leiomyosarcoma have been described in the literature (4). Leiomyosarcomas are characterized by slow growth and late metastases and thus, exhibit a better prognosis than squamous cell carcinoma of the esophagus (5). The one-, three-and five-year survival rates of esophageal leiomyosarcoma in the Chinese population are 60.3, 42.8 and 32.1%, respectively (5). The most common symptom observed at diagnosis is progressive dysphagia which occurs in 64.7-90.0% of esophageal leiomyosarcoma patients. Other symptoms include retrosternal/back pain, weight loss and emesis (6,7). The development of definite treatment strategies is difficult due to the rarity of these tumors. Currently, surgical resection is the first-line treatment (6); however, surgical resection is not suitable for all patients. Although leiomyosarcoma is not sensitive to radiation, radiotherapy can be used to control the tumor effectively by appropriately increasing the radiation dose (8-12). The present study describes a case of leiomyosarcoma of the esophagus that was treated with radiation, rather than surgery. In addition, the current study conducted a review the relevant literature. Written informed consent was obtained from the patient. Case reportIn May 2009, a 48-year-old woman presented with 6 kg weight loss in two months and a six-month history of dysphagia to solids, which had been aggravated for two months, at the Shandong Cancer Hospital and Institute (Jinan, China). Computerized tomography (CT) scanning of the chest revealed the presence of a round so...

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Esophageal sarcomas

Cited by 47 publications

References 21 publications

Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

Esophageal schwannoma treated by transthoracic esophagectomy: a case report

Radiotherapy treatment of large esophageal leiomyosarcoma: A case report

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