Esophageal Neuroendocrine Carcinoma: Case Report and Literature Review

Vayzband, Vlad; Doukas, Sotirios G.; Esparragoza, Paola

doi:10.7759/cureus.23607

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…13 This is likely related to the aggressive nature of ENEC because metastases are often present at diagnosis, as in this case. 14 Patients and providers should discuss the risk of radiation-related cancer, and patients who receive radiation should be followed closely for RIM. The literature on ENEC outcomes and the development of ENEC in a previously irradiated field is scarce, and our case adds to the limited information on this rare phenomenon.…”

Section: Discussionmentioning

confidence: 99%

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Esophageal Neuroendocrine Carcinoma Presenting After Definitive Chemoradiation of Squamous Cell Carcinoma in the Same Location

et al. 2023

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Esophageal neuroendocrine carcinoma is very rare and highly aggressive. An 85-year-old man with a history of esophageal squamous cell carcinoma in remission presented 4 years after definitive chemoradiation with new-onset dysphagia. Endoscopy with biopsy revealed high-grade malignancy consistent with neuroendocrine carcinoma. Treatment options were limited to chemotherapy because of his metastatic disease, and he unfortunately died 14 months after diagnosis. The occurrence of esophageal neuroendocrine carcinoma in a site of prior squamous cell carcinoma is very uncommon, and this likely represents a case of radiation-induced malignancy. Therefore, when undergoing radiotherapy, patients and providers should discuss the possibility of this life-threatening complication.

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Section: Discussionmentioning

confidence: 99%

“… 13 This is likely related to the aggressive nature of ENEC because metastases are often present at diagnosis, as in this case. 14 …”

Section: Discussionmentioning

confidence: 99%

Esophageal Neuroendocrine Carcinoma Presenting After Definitive Chemoradiation of Squamous Cell Carcinoma in the Same Location

et al. 2023

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High-grade large cell neuroendocrine carcinoma of the esophagus: a case report and review of the literature

et al. 2023

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Background Neuroendocrine carcinomas are extremely rare in the esophagus as they represent less than 0.04% of all neuroendocrine tumors. To date, only 14 cases of poorly differentiated, high-grade esophageal NEC have been described in the literature. The majority of these patients presented with typical dysphagia symptoms. Due to its rarity, no standardized guidelines have been proposed to treat esophageal neuroendocrine carcinoma, although general recommendations suggest surgery with adjuvant chemoradiotherapy as the treatment of choice. Case presentation A 67-year-old previously healthy White male presented with a year-long intermittent nonspecific retrosternal discomfort, with the absence of any other symptoms. Esophagogastroduodenoscopy revealed an ulcerative mass in his lower esophagus, with concern of malignancy. Endoscopic ultrasound-guided biopsy revealed poorly differentiated neuroendocrine carcinoma of the esophagus with metastasis to a diaphragmatic lymph node. He was treated with neoadjuvant chemoradiation followed by surgery, and he has been in remission for over 5 years. Conclusion Here, we review the literature and report a unique case of a patient with a vague presentation of esophageal neuroendocrine carcinoma as he enters his sixth year of survival following neoadjuvant chemoradiotherapy.

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Esophageal Neuroendocrine Carcinoma: Case Report and Literature Review

Cited by 2 publications

References 8 publications

Esophageal Neuroendocrine Carcinoma Presenting After Definitive Chemoradiation of Squamous Cell Carcinoma in the Same Location

Esophageal Neuroendocrine Carcinoma Presenting After Definitive Chemoradiation of Squamous Cell Carcinoma in the Same Location

High-grade large cell neuroendocrine carcinoma of the esophagus: a case report and review of the literature

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