Esophageal motility disorders in patients with Sjögren's syndrome

Palma, Rui; Freire, Ana Ponces; Freitas, J. P.; Morbey, A.; Costa, Teixeira da; Saraiva, Fernando; Queirós, Fátima Marisa Moreira; Carvalhinhos, A

doi:10.1007/bf02087419

Cited by 37 publications

(11 citation statements)

References 5 publications

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“…Xerostomia in SS is capable of causing dysphagia directly through the inability of saliva to lubricate the upper aerodigestive tract and assist with bolus transport. Various investigators, however, have failed to show an association between the presence of dysphagia and the degree of xerostomia [3,11]. Thus, evidence exists to suggest that dysphagia in persons with SS is not directly caused by the diminution of saliva.…”

Section: Introductionmentioning

confidence: 99%

The laryngeal and esophageal manifestations of Sjögren’s syndrome

Belafsky

Postma²

2003

Curr Rheumatol Rep

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Laryngopharyngeal reflux (LPR) is the syndrome caused by the backflow of gastric contents into the upper aerodigestive tract. Acid and pepsin in the pharynx, larynx, oral cavity, and trachea have been associated with dysphonia, chronic cough, reactive airway disease, middle ear effusion, throat pain, excessive throat mucus, postnasal drip, dental caries, and laryngeal cancer. The symptoms of LPR frequently occur in the absence of heartburn and esophagitis, and, thus, the diagnosis may be elusive. Individuals with Sjögren's syndrome are predisposed to reflux, and a high index of suspicion for LPR must be maintained in all individuals with the disease. This manuscript describes the laryngeal, pharyngeal, and esophageal manifestations of reflux in patients with Sjögren's syndrome and reviews state-of-the-art diagnostic and treatment strategies.

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Section: Introductionmentioning

confidence: 99%

The laryngeal and esophageal manifestations of Sjögren’s syndrome

Belafsky

Postma²

2003

Curr Rheumatol Rep

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“…Dysphagia is a common complaint in SS and does not correlate only with the xerostomia that is a typical finding of the disease. In many papers3, 18, 21, 23 about the gastrointestinal manifestations of SS, a high incidence of esophageal motility disorders has been reported, and dysphagia is thought to be a consequence of both lack of saliva and esophageal dysmotility.…”

Section: Discussionmentioning

confidence: 99%

Sensory ataxic neuropathy and esophageal achalasia in a patient with Sjogren's syndrome

2007

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We describe a patient who developed an ataxic sensory syndrome associated with xerophthalmia and progressive dysphagia with regurgitation. Electrophysiological findings were consistent with an axonal sensory neuropathy, and superficial peroneal nerve biopsy showed a reduction in number of myelinated fibers with epineurial inflammation. Rheumatoid factor, anti-SSA/SSB and antinuclear antibodies were positive and a diagnosis of Sjogren's syndrome was made. An endoscopic investigation revealed esophageal achalasia. We suggest that there may be a common autoimmune mechanism directed to different targets on the basis of this rare association.

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“…Na origem da disfagia, encontrada na quase totalidade dos pacientes, ao longo da evolução da doença, em concordância com os dados da literatura, estão implicados vários mecanismos, como a diminuição da quantidade e qualidade dos componentes da saliva, a destruição das glândulas secretoras de muco do 1/3 superior do esôfago pelo infiltrado linfocitário e as alterações musculares e de enervação que dificultam a progressão do bolo alimentar (38,39) .…”

Section: Discussionunclassified