Esophageal metastasis secondary to extranodal nasal-type natural killer/T-cell lymphoma: A case report

Abstract

Abstract. We herein report a case of recurrent nasal natural killer (NK)/T-cell lymphoma in a 21-year-old male patient. The patient presented with an esophageal mass, fever and difficulty in swallowing. There were no other obvious sites of recurrence apart from the esophageal lesion. Metastatic esophageal lesions are extremely rare. The histological analysis demonstrated a highly aggressive tumor with a characteristic angiodestructive growth pattern and nasal cavity necrosis. The lymphoma cells were immunopositive for leukocyte common antigen, T-cell intracytoplasmic antigen 1 and CD68, negative for CD56 and CD3, and positive for Epstein-Barr virus. A computed tomography scan revealed mild thickening of the wall of the lower esophagus. The barium swallow revealed stiffness of the esophageal wall, with limited expansion and mucosal damage. The final diagnosis was primary nasal NK/T-cell lymphoma, with metastasis to the esophagus. Clinically, it is important to distinguish nasal-type NK/T-cell lymphoma from other types of tumors, as its prognosis and treatment of secondary metastases differ significantly.

Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature

“…Age, symptoms, local tumor invasion, clinical stage, treatment response, NK/T cell IPI, LDH, and EBV infection were reported to be prognostic in ENKTL [ 30 ]. Although lacking statistical data, some literature reported distant metastasis and bone marrow involvement, with a very poor prognosis [ 31 ]. Our patient had unfavorable prognostic factors (EBV infection, distant metastasis, and bone marrow involvement), and the available data on optimal treatment strategies are limited.…”