2012
DOI: 10.1111/j.1442-2050.2012.01444.x
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Esophageal leiomyosarcoma: clinical analysis and surgical treatment of 12 cases

Abstract: Leiomyosarcoma of the esophagus is a rare malignant tumor with slow growth and late metastasis. The aim of this study was to reassess the clinical characteristics and treatment modality in one of the largest series of esophageal leiomyosarcomas from a single institution. From February 1973 to December 2011, 12 cases of esophageal leiomyosarcoma were identified. The principal symptoms included progressive dysphagia in 11 cases (91.7%), retrosternal/back pain in four (33.3%), weight loss in four (33.3%), upper g… Show more

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Cited by 23 publications
(26 citation statements)
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References 20 publications
(59 reference statements)
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“…Our limited data show that leiomyosarcoma (n ¼ 2) had the best survival after surgical resection: of 10.7 years and 18.7 years in 1 patient each. Leiomyosarcomas are malignant smooth muscle tumors that are generally less aggressive then squamous cell carcinoma of the esophagus, thus having better survival, which is consistent with our observations [23,24]. Unfortunately, 6 patients survived less than 1 year after resection; they included patients with GIST, undifferentiated carcinoma, lymphoma, sarcoma, and sarcomatoid carcinoma [25][26][27].…”
Section: Commentsupporting
confidence: 91%
“…Our limited data show that leiomyosarcoma (n ¼ 2) had the best survival after surgical resection: of 10.7 years and 18.7 years in 1 patient each. Leiomyosarcomas are malignant smooth muscle tumors that are generally less aggressive then squamous cell carcinoma of the esophagus, thus having better survival, which is consistent with our observations [23,24]. Unfortunately, 6 patients survived less than 1 year after resection; they included patients with GIST, undifferentiated carcinoma, lymphoma, sarcoma, and sarcomatoid carcinoma [25][26][27].…”
Section: Commentsupporting
confidence: 91%
“…Leiomyosarcomas are most commonly located in the middle and lower thoracic esophagus because smooth muscle predominates in that area [5]. Esophageal leiomyosarcomas are typically divided into two types: the polypoid type, representing 60% of cases; and infiltrative type in 40% [6,7].…”
Section: Discussionmentioning
confidence: 99%
“…Esophageal leiomyosarcoma typically occurs in the middle to distal third of the esophagus because the muscularis propria in that area consists of smooth muscle [5]. These lesions are generally small and asymptomatic, but occasionally can be large and produce dysphagia.…”
Section: Introductionmentioning
confidence: 99%
“…Leiomyosarcoma is typically associated with a good prognosis due to its slow growth and the late occurrence of metastasis (27). However, due to its rarity, it is difficult to determine a pre-operative diagnosis and appropriate treatment strategy for cases of esophageal leiomyosarcoma.…”
Section: Discussionmentioning
confidence: 99%