Esophageal leiomyosarcoma: clinical analysis and surgical treatment of 12 cases

Zhang, B. H.; Zhang, H. T.; Wang, Y. G.

doi:10.1111/j.1442-2050.2012.01444.x

Cited by 23 publications

(26 citation statements)

References 20 publications

(59 reference statements)

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“…Our limited data show that leiomyosarcoma (n ¼ 2) had the best survival after surgical resection: of 10.7 years and 18.7 years in 1 patient each. Leiomyosarcomas are malignant smooth muscle tumors that are generally less aggressive then squamous cell carcinoma of the esophagus, thus having better survival, which is consistent with our observations [23,24]. Unfortunately, 6 patients survived less than 1 year after resection; they included patients with GIST, undifferentiated carcinoma, lymphoma, sarcoma, and sarcomatoid carcinoma [25][26][27].…”

Section: Commentsupporting

confidence: 91%

Surgical Resection of Rare Esophageal Cancers

Saddoughi

Taswell

Harmsen

et al. 2016

The Annals of Thoracic Surgery

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Section: Commentsupporting

confidence: 91%

Surgical Resection of Rare Esophageal Cancers

Saddoughi

Taswell

Harmsen

et al. 2016

The Annals of Thoracic Surgery

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“…Leiomyosarcomas are most commonly located in the middle and lower thoracic esophagus because smooth muscle predominates in that area [5]. Esophageal leiomyosarcomas are typically divided into two types: the polypoid type, representing 60% of cases; and infiltrative type in 40% [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Esophageal leiomyosarcoma typically occurs in the middle to distal third of the esophagus because the muscularis propria in that area consists of smooth muscle [5]. These lesions are generally small and asymptomatic, but occasionally can be large and produce dysphagia.…”

Section: Introductionmentioning

confidence: 99%

Radiation-Induced Esophageal Leiomyosarcoma 13 Years after Mediastinal Irradiation Following Surgical Removal of a Thymoma

Hidaka¹

2015

J Nucl Med Radiat Ther

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Radiation-induced leiomyosarcoma is a very rare complication following irradiation of primary malignancies. In the chest wall, it is usually secondary to radiotherapy for breast cancer or lymphoma. Esophageal malignancy is a radiation dose-related complication of radiotherapy for breast cancer, but its absolute risk is low. A 61-year-old woman presented with an esophageal leiomyosarcoma 13 years after surgery plus mediastinal irradiation (55 Gy) for a stage III thymoma. Esophageal sarcoma is an uncommon tumor, reported sporadically in the literature. Radiotherapy is frequently used in the treatment of carcinoma of the esophagus, and the increased risk of development of sarcoma arising in irradiated fields is well known. The increasing use of radiotherapy for thymoma suggests that radiation-associated malignancies of the esophagus may be seen more frequently in the future. To the best of our knowledge, this is the first report of radiation-induced esophageal leiomyosarcoma after mediastinal irradiation of a thymoma.

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“…Leiomyosarcoma is typically associated with a good prognosis due to its slow growth and the late occurrence of metastasis (27). However, due to its rarity, it is difficult to determine a pre-operative diagnosis and appropriate treatment strategy for cases of esophageal leiomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy treatment of large esophageal leiomyosarcoma: A case report

Wang³

et al. 2015

Oncology Letters

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Abstract. Leiomyosarcoma of the esophagus is a rare type of tumor, characterized by a malignant phenotype and smooth muscle histology. Previously, barium studies have been used to identify areas of luminal narrowing, expansile intraluminal masses or large intramural masses with ulceration or tracking. Furthermore, endoscopic biopsies appear to be associated with a high false negative rate, particularly in cases where the mucosa is intact. The optimal treatment strategy is surgical resection, while the role of adjuvant radiotherapy and chemotherapy is controversial. In addition, the prognosis of patients with leiomyosarcoma of the esophagus is improved compared with patients suffering from squamous esophageal cancer. The present study described the case of a 48-year-old woman who presented with dysphagia and was diagnosed with a large leiomyosarcoma of the esophagus. The patient was successfully treated with radiotherapy and remains disease-free two years after the completion of treatment. In addition, the present study conducted a review of the relevant literature, reporting previous cases of esophageal leiomyosarcoma and potential strategies for the management of this disease. IntroductionSquamous cell and adenocarcinoma are the two most common types of esophageal malignancies, whereas esophageal leiomyosarcoma is a rare type of tumor, accounting for <1% of all malignant esophageal tumors (1,2). Since the first case of esophageal leiomyosarcoma was reported in 1902 (3), >165 cases of esophageal leiomyosarcoma have been described in the literature (4). Leiomyosarcomas are characterized by slow growth and late metastases and thus, exhibit a better prognosis than squamous cell carcinoma of the esophagus (5). The one-, three-and five-year survival rates of esophageal leiomyosarcoma in the Chinese population are 60.3, 42.8 and 32.1%, respectively (5). The most common symptom observed at diagnosis is progressive dysphagia which occurs in 64.7-90.0% of esophageal leiomyosarcoma patients. Other symptoms include retrosternal/back pain, weight loss and emesis (6,7). The development of definite treatment strategies is difficult due to the rarity of these tumors. Currently, surgical resection is the first-line treatment (6); however, surgical resection is not suitable for all patients. Although leiomyosarcoma is not sensitive to radiation, radiotherapy can be used to control the tumor effectively by appropriately increasing the radiation dose (8-12). The present study describes a case of leiomyosarcoma of the esophagus that was treated with radiation, rather than surgery. In addition, the current study conducted a review the relevant literature. Written informed consent was obtained from the patient. Case reportIn May 2009, a 48-year-old woman presented with 6 kg weight loss in two months and a six-month history of dysphagia to solids, which had been aggravated for two months, at the Shandong Cancer Hospital and Institute (Jinan, China). Computerized tomography (CT) scanning of the chest revealed the presence of a round so...

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Esophageal leiomyosarcoma: clinical analysis and surgical treatment of 12 cases

Cited by 23 publications

References 20 publications

Surgical Resection of Rare Esophageal Cancers

Surgical Resection of Rare Esophageal Cancers

Radiation-Induced Esophageal Leiomyosarcoma 13 Years after Mediastinal Irradiation Following Surgical Removal of a Thymoma

Radiotherapy treatment of large esophageal leiomyosarcoma: A case report

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