Esophageal Involvement in Behcetʼs Syndrome

Anti, M.; Marra, Giancarlo; Gl, Rapaccini; Barone, Christina; Manna, Raffaele; Gb, Bochicchio; Fedeli, G.

doi:10.1097/00004836-198610000-00004

Cited by 27 publications

(5 citation statements)

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“…Histology is nonspecific, showing lymphocytic or neutrophilic infiltration rather than vasculitis. The lesions may be resistant to treatment with a proton pump inhibitor but resolve with corticosteroids [33,34]. Since BD is treated with immunosuppressive agents, viral or candida esophagitis should be excluded.…”

Section: Gastrointestinal (Gi) Diseasementioning

confidence: 99%

Gastrointestinal Manifestations of Behçet’s Disease

Ebert

2008

Dig Dis Sci

113

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Behçet's disease is a rare vasculitis diagnosed by the presence of recurrent oral ulcers and two of the following: genital ulcers, typical eye lesions, typical skin lesions, and positive pathergy test. It is most commonly seen in countries along the ancient silk road from Eastern Asia to the Mediterranean Basin. Young adults between the second and fourth decades of life are mainly affected, with abdominal pain being the most common symptom. The ileocecal region is most commonly affected, with ulcerations that may penetrate or perforate. Rarely, the esophagus and stomach may have ulcerations. Bowel wall thickening is the most common finding on computed tomography (CT) scan. Pathology shows a vasculitis mainly involving the small veins or, alternatively, nonspecific inflammation. Corticosteroids, with or without other immunosuppressive drugs, are used for severe eye disease. Their use in intestinal disease is largely empirical. Surgery may be required for perforation. Behçet's disease runs a chronic, unpredictable course with exacerbations and remissions which decrease in frequency and severity over time. Death is mainly due to major vessel disease and neurological involvement.

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Section: Gastrointestinal (Gi) Diseasementioning

confidence: 99%

Gastrointestinal Manifestations of Behçet’s Disease

Ebert

2008

Dig Dis Sci

113

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“…3 This can cause abdominal pain, diarrhea, and hematochezia, making BD indistinguishable from pseudomembranous colitis due to C difficile intoxication, other infectious causes of dysentery or colitis, and inflammatory bowel diseases such as ulcerative colitis and Crohn disease. [11][12][13] Neurological manifestations occur in 23% of patients with BD in the United States. Typically, it takes approximately 4 to 5 years for central nervous system (CNS) symptoms to appear.…”

Section: Discussionmentioning

confidence: 99%

Behçet Disease Presenting With Pseudomembranous Colitis and Progression to Neurological Involvement

Shukla

Tolan

2012

Clin Pediatr (Phila)

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“…11,15 Esophageal involvement in Behçet's disease, however, is very uncommon and less than 50 cases have been reported in the literature. [5][6][7]9,10,14 According to these reports, the esophageal lesions are mainly nonspecific ulcers in the middle and/or the lower esophagus, and serious complications such as erosions, perforations, esophagitis, stenosis, and varices have been rarely described. 8 Brodie and Ochsner reported the first case of esophageal penetration in Behçet's disease in 1973.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] Esophageal involvement in Behçet's disease is very uncommon and to date less than 50 cases have been reported. [5][6][7][8][9][10] This report describes esophagobronchial fistula in a patient associated with intestinal Behçet's disease.…”

Section: Introductionmentioning

confidence: 99%

Esophagobronchial Fistula in a Patient with Behçet’s Disease: Report of a Case

et al. 2005

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Esophageal involvement in Behçet's disease is generally considered to be very uncommon. So far, six cases of esophageal ulcers associated with perforation, penetration, or fistula in Behçet's disease have been described in the English literature. This report describes esophagobronchial fistula in a patient with intestinal Behçet's disease. A 62-year-old man was transferred to our hospital for peritonitis due to a small intestinal perforation after an appendectomy. At the age of 14 years he had had recurrent oral ulcers. Ulcerations of the ileum and epididymitis were found, and a pathological examination revealed nonspecific inflammation. Furthermore, an esophageal ulcer with esophagobronchial fistula was diagnosed. The fistula required not only endoscopic treatment but also surgical intervention. The patient's clinical features were consistent with the active phase of intestinal Behçet's disease. The symptoms gradually resolved without any treatment. Four years after remission, however, the symptoms recurred with gastrointestinal hemorrhage and polyarthritis. In the ileocolic region, punch-out ulcerations were noted. The clinical history and features led to a diagnosis of Behçet's disease associated with recurrent gastrointestinal ulcerations. Steroid therapy (prednisolone, 20 mg daily) was started, and led to a rapid resolution of the symptoms. The patient is now being followed up as an outpatient while receiving prednisolone (10 mg per day), without complaint of any gastrointestinal symptoms.

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Esophageal Involvement in Behcetʼs Syndrome

Cited by 27 publications

References 0 publications

Gastrointestinal Manifestations of Behçet’s Disease

Gastrointestinal Manifestations of Behçet’s Disease

Behçet Disease Presenting With Pseudomembranous Colitis and Progression to Neurological Involvement

Esophagobronchial Fistula in a Patient with Behçet’s Disease: Report of a Case

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