Esophageal Infections in Immunosuppressed Patients After Marrow Transplantation

McDonald, George B.; Sharma, Pankaj; Hackman, Robert C.; Meyers, Joel D.; Ed, Thomas

doi:10.1016/s0016-5085(85)80068-8

Cited by 170 publications

(74 citation statements)

References 41 publications

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“…6 -8 - 14 In addition, nonbacterial thrombotic endocarditis was not found in the present series, although a frequency of 7% to 9% has been reported elsewhere. 615 Viral esophageal infections were found in 20 of 59 autopsies of patients after BMT, 16 but none were found in the present study. A variety of factors, including advances in antibiotic therapy and leukocyte stimulation, may have influenced this shift.…”

Section: Discussioncontrasting

confidence: 64%

Autopsy Findings in Umbilical Cord Blood Transplant Recipients

Nuckols

1999

Am J Clin Pathol

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Section: Discussioncontrasting

confidence: 64%

Autopsy Findings in Umbilical Cord Blood Transplant Recipients

Nuckols

1999

Am J Clin Pathol

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“…Historically, common causes of these complaints were either infectious esophagitis or chemo/radiotherapy-induced esophagitis. In an early study, McDonald et al 8 found 54% of patients with symptoms had esophageal infection, the majority of which were virus induced. Wheeler et al 9 showed that 47% of patients with dysphagia had fungal infections while 13% had viral infections.…”

Section: Discussionmentioning

confidence: 99%

Does gastroenterology consultation change management of patients receiving hematopoietic stem cell transplantation?

Fallows

Rubinger

Bernstein

2001

Bone Marrow Transplant

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Summary:Gastrointestinal complications following hematopoietic stem cell transplantations (HSCTs) are common, but it is unknown how often gastroenterology consultation (GEC) early post BMT leads to specific changes in patient management. We aimed to determine the reason(s) for GEC, the diagnoses found through GEC, whether the advice or intervention led to change(s) in management and if intervention led to any adverse outcome within the first 100 days post HSCT. We undertook a retrospective review of all patients at least 18 years old (n ‫؍‬ 197) who underwent HSCT between November 1990 and April 1998. Of these, 79 patients had 92 consultations for a total of 163 separate GE problems within the first 100 days post HSCT. Data were obtained through chart review. It was determined whether the intervention or advice given by the consultant led to actual changes in patient management or outcome. We found that the characteristics more likely to be associated with GEC included female patient vs male (P ‫؍‬ 0.03), allogeneic vs autologous transplants (P Ͻ 0.001), hematologic vs solid malignancies (P ‫؍‬ 0.006), and leukemias vs lymphomas (P ‫؍‬ 0.013). Overall, a definitive diagnosis for an identified complaint was made in 71% (range 25-87%). A change in management was effected in 54% of cases (range 0-59%). Endoscopy led to perforation and subsequent death in two patients (1.8%). Gastrointestinal disease was a direct cause of death in 2.5% of all patients. In conclusion, a definite diagnosis was reached in 71% of gastrointestinal problems and management was effected in 54% of cases. Since endoscopy was associated with a mortality of 1.8%, minimizing its use for the cases in which no impact is made, should be considered. Bone Marrow Transplantation (2001) 28, 289-294.

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“…Cytomegalovirus has been detected in most parts of the gastrointestinal tract from the oesophagus to the anus (Wong & Warner, 1962;McDonald et al 1985). It is frequently found in the base of ulcers and may be associated with severe haemorrhage.…”

Section: Gastrointe8titnal Infectionmentioning

confidence: 99%

The status of CMV as a human pathogen

Griffiths

Grundy

1988

Epidemiol. Infect.

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Cytomegalovirus (CMV) is a common infectious agent which is well adapted to its host. Following primary infection, which is almost always asymptomatic in people with normal immunity, the virus establishes latency at sites which are unknown. The virus is probably maintained in this latent state by immune surveillance mechanisms since immunosuppression frequently leads to reactivation of virus.Cytomegalovirus has been identified in most anatomical areas of the human body. The aim of this article is to define criteria for pathogenicity so that clinical and experimental data can be reviewed to determine if CMV is likely to cause disease at these various clinical sites. Thus, patients have been shown to die frequentlywithCMV but do they diefromit?

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Esophageal Infections in Immunosuppressed Patients After Marrow Transplantation

Cited by 170 publications

References 41 publications

Autopsy Findings in Umbilical Cord Blood Transplant Recipients

Autopsy Findings in Umbilical Cord Blood Transplant Recipients

Does gastroenterology consultation change management of patients receiving hematopoietic stem cell transplantation?

The status of CMV as a human pathogen

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