Esophageal granular cell tumors: Report of 9 cases and a literature review

Abstract

Esophageal granular cell tumors (GCTs) are rare tumors of the esophagus. We evaluated the clinical and pathologic features of 9 esophageal GCT patients (5 men and 4 women) from our institute and reviewed the related disease literature. Patient age ranged from 25 to 53 years (mean: 41 years). All the patients were asymptomatic or presented with non-specific symptoms. Most GCTs occurred in the distal esophagus and were less than 6 mm in diameter. Computational analysis showed that the average gray-scale endoscopic ultrasound images of esophageal GCTs were greater than that of esophageal leiomyomas. Eight patients were treated by endoscopic resection, and 1 patient underwent surgical excision. No post-therapy recurrence or metastasis developed during follow-up (mean: 36.4 mo, range: 1-72 mo).

Granular cell tumor of the esophagus in an adolescent

“…Esophageal GCT is found in the distal (50%–65%), proximal (15%–40%), and midesophagus (20 %). Most cases are solitary, but multiple lesions in the esophagus occur in 10% of cases26). Cases of esophageal GCT are usually asymptomatic and found incidentally during endoscopy or a GI contrast study.…”

Esophageal granular cell tumor: evaluation of pathological and clinical findings in series of 7 cases

“…GCT olgularının büyük kısmı mukoza ya da submukozadan köken alsa da az sayıda tümörün muskularis propriadan kaynaklandığı bildirilmiştir (2,4,8) .…”

“…İm-münhistokimyasal olarak yaygın ve güçlü S100 pozitifliği belirlenir. İmmünhistokimyasal olarak ayrıca Nöron Spesifik Enolaz, Vimentin ve Nestin ile pozitif (4,11) , Düz Kas Aktini (SMA) ve Desmin ile negatiftirler (2,8) . Olgularımızda tüm bu histopatolojik tanı ölçütleri gözlendi.…”

“…'yi aşan tümörler için endoskopik veya cerrahi rezeksiyon uygulanabileceği bildirilmiş-tir. Mukozal ve submukozal yerleşimli lezyonlarda tedavi için endoskopik mukozal rezeksiyon (EMR)'un yeterli olduğu ve komplikasyonsuz başarılı sonuçlar verdiği bildirilmektedir (8) . ESD'nin EMR'ye göre daha düzgün sınırlarla eksizyon olanağı sağladığı öne sürülmüştür (3) .…”

Subepithelial Lesions

“…These tumors are usually asymptomatic and found incidentally, but rarely can ulcerate, bleed, or obstruct. They are generally considered benign, although rare occurrences of malignant transformation have been reported in large GCTs (> 4 cm size) or tumors that exhibit rapid recent growth and/or rapid recurrence after excision [101][102][103].…”