Esophageal Dysmotility is More Common Than Gastroparesis in Diabetes Mellitus and is Associated With Retinopathy

Gustafsson, Rita; Littorin, Bengt; Berntorp, Kerstin; Frid, Anders; Thorsson, Ola; Olsson, Rolf; Ekberg, Olle; Ohlsson, Bodil

doi:10.1900/rds.2011.8.268

Cited by 60 publications

(59 citation statements)

References 30 publications

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“…The lack of association between colonic microangiopathy and diabetes duration in the present study is not in accordance with our previous results, where an association between esophageal complications (but not gastroparesis) and duration was found [10]. As the vast majority of the patients had type 2 diabetes, the exact onset of the disease, and thus the duration, may be uncertain.…”

Section: Resultscontrasting

confidence: 85%

“…In turn, gastroparesis and dysmotility may cause poor metabolic control in the patients by nonregular emptying rates [1,2]. The association between gastrointestinal dysmotility and retinopathy may thus be based on a poor glycemic control, with increased risk of developing retinopathy, rather than another common causality behind the two complications [4,5,10].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the information about duration of diabetes was missing for some of the patients. Possibly, diabetes duration may be more closely related to retinopathy and microalbuminuria [10,19,24] than to other complications [10,20].…”

Section: Resultsmentioning

confidence: 99%

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Microangiopathy is Common in Submucosal Vessels of the Colon in Patients With Diabetes Mellitus

Sasor¹,

Ohlsson²

2014

Rev Diabet Stud

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■ Abstract OBJECTIVES:The pathophysiology behind gastrointestinal dysmotility in diabetes mellitus is unknown. Both esophageal dysmotility and gastroparesis have been shown to be associated with retinopathy, suggesting that microangiopathy is important in the common etiology. The aim of the present study was to examine whether patients with diabetes exhibit microangiopathy in the colon, and if present, to correlate microangiopathy with the clinical picture. METHODS: Consecutive patients subjected to colon surgery were identified in the southernmost districts of Skåne between January 2011 and May 2013. Medical records were scrutinized, and patients with a history of diabetes were noted. Gender, age, type of diabetes, treatment, complications, and other concomitant diseases were registered. Histopathologic reevaluation of surgical biopsies with morphometric analyses of submucosal vessels in the colon was performed. Morphometric examination and clinical data were compared with non-diabetic patients. RESULTS: Of 1135 identified patients during the time period studied, 95 patients with diabetes were recognized and included. Fifty-three non-diabetic, randomly chosen patients served as controls. The mean age was 71.8 ± 10.2 and 71.4 ± 9.5 years in diabetic and nondiabetic patients, respectively. Microangiopathy was found in 68.4% of diabetic patients and in 7.5% of non-diabetic patients (p < 0.001). The wall-to-lumen ratio was 0.31 (0.23-0.46) in patients with diabetes compared with 0.16 (0.12-0.21) in non-diabetic patients (p < 0.001). No clinical association with microangiopathy could be verified. CONCLU-SION: Microangiopathy in the colon is more common in diabetic than in non-diabetic patients. The clinical significance of microangopathy has yet to be clarified.

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Section: Resultscontrasting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

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Microangiopathy is Common in Submucosal Vessels of the Colon in Patients With Diabetes Mellitus

Sasor¹,

Ohlsson²

2014

Rev Diabet Stud

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“…At the time of inclusion, the patients completed an established questionnaire regarding symptoms related to complications of the gastrointestinal tract, namely, loss of appetite, swallow complications, meal-related cough, early satiety, nausea, vomiting, weight loss, abdominal fullness, bloating, regurgitation, constipation, diarrhea, evacuation incontinence, symptomatic postprandial hypoglycemia, and postprandial perspiration [3,5]. Patients were weighed and measured to calculate body mass index (BMI).…”

Section: Diabetes Subjectsmentioning

confidence: 99%

“…Fat generates the most potent feedback because of its high caloric density [2]. Apart from gastroparesis, esophageal dysmotility is found in up to 60% of patients with diabetes [3]. Autonomic neuropathy is well established as a complication in diabetes, and is one possible etiology of gastrointestinal dysmotility [1,4].…”

Section: Introductionmentioning

confidence: 99%

Esophageal and Gastric Dysmotilities are Associated with Altered Glucose Homeostasis and Plasma Levels of Incretins and Leptin

et al. 2016

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■ Abstract BACKGROUND:Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucosedependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin. METHODS: Sixteen diabetes patients (seven men) were examined with gastric emptying scintigraphy and 72-h continuous subcutaneous glucose monitoring, 14 with the deep-breathing test, and 12 with esophageal manometry. A fiber-rich breakfast was given during the second day of glucose registration. Blood samples were taken 10 min and right before a fat-rich breakfast, as well as 10, 20, 30, 45, 60, 90, 120, 150, and

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Diabetic Neuropathy

Azmi,

Alam,

Malik

2024

Textbook of Diabetes

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Esophageal Dysmotility is More Common Than Gastroparesis in Diabetes Mellitus and is Associated With Retinopathy

Abstract: Esophageal dysmotility is more common than gastroparesis in diabetes mellitus independent of gender, symptoms, and type of diabetes. There is a strong association between retinopathy and esophageal dysmotility.

Cited by 60 publications

References 30 publications

Microangiopathy is Common in Submucosal Vessels of the Colon in Patients With Diabetes Mellitus

Microangiopathy is Common in Submucosal Vessels of the Colon in Patients With Diabetes Mellitus

Esophageal and Gastric Dysmotilities are Associated with Altered Glucose Homeostasis and Plasma Levels of Incretins and Leptin

Diabetic Neuropathy

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