Esophageal dysmotility and lung disease in patients with systemic sclerosis: is there a possible association or correlation? A retrospective chart review

Systemic sclerosis: one year in review 2022

“…It was proposed that a complementary approach of evaluating primary peristalsis with high-resolution manometry and secondary peristalsis with Functional luminal imaging probe Panometry facilitated the characterisation of oesophageal function in SSc (81). In a study on 130 SSc patients, the presence of oesophageal dysmotility was associated with abnormal DLco (82). Transabdominal oesophageal ultrasound was tested in a pilot study on 38 SSc.…”

Development of a Diagnostic Model Focusing on Esophageal Dysmotility in Patients with Systemic Sclerosis

“…The presence of ILD was also included as a predictor for esophageal dysmotility. Most studies have observed a correlation between esophageal dysmotility on HRM and the presence of ILD on HRCT and DLCO < 0.8 of predicted value due to lung injury through micro-aspiration [ 3 , 4 , 8 , 14 ]. Meanwhile, some studies have found that esophageal dysmotility is related to the progress of pulmonary fibrosis.…”

“…Esophageal dysmotility may reduce the quality of life and lead to depression [ 3 , 5 , 6 ]. In particular, there is also growing evidence that microaspiration resulting from esophageal dysmotility induces interstitial lung disease and deteriorates lung function [ 3 , 4 , 7 , 8 ], and progressive esophageal dysmotility may negatively impact posttransplant outcomes and survival [ 9 ]. Although esophageal dysmotility is deemed an important part of the Scleroderma Clinical Trials Consortium Impairment Index to quantitate the organ damage in SSc [ 10 ], an appropriate screening strategy for esophageal dysmotility in clinical practice is still a problem.…”