Esophageal Disorders Caused by Medications, Trauma, and Infection

Katzka, David A.

doi:10.1016/b978-1-4160-6189-2.00045-7

Cited by 10 publications

(20 citation statements)

References 160 publications

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“…Endoscopy allows for direct inspection, biopsy-taking, cytology-sampling and microbiological tests. 6,9 We performed endoscopy in all of our patients, and our data comprise a total of 8 patients, 4 has ulcer at mid-distal esophagus, 3 at mid esophagus, and 1 at distal esophagus. These findings are consistent with some studies which found out that most clindamycin-induced esophagitis located at distal or middle part of esophagus.…”

Section: Discussionmentioning

confidence: 99%

“…With the advance of gastrointestinal endoscopy, it is expected to detect pill-induced esophagitis more frequently and to have better understanding of the course of the disease. 6,7 To the best of our knowledge, the latest pill-induced esophagitis report is by Zhang et al 8 in 2018 that reported esophagitis as a rare side effect of ascorbic acid. The purpose of this study was to explore the clinical and endoscopic features, especially, of clindamycin-induced esophageal injury.…”

Section: Introductionmentioning

confidence: 99%

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Clindamycin-Induced Esophageal Injury: Is It an Underdiagnosed Entity?

Bestari

Agustanti

Abdurachman

2019

Clin Med Insights Case Rep

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There are increased reports of pill-induced esophagitis in the past 2 decades, with almost 100 different substances identified as the cause for more than 700 cases, and the overall incidence is estimated to be 0.004% per year. Antibiotics are one of the major contributors for these cases, especially tetracycline and doxycycline; other major contributors are bisphosphonates, nonsteroidal anti-inflammatory drugs, and iron pills. Clindamycin is commonly prescribed by physicians, yet side effect in the form of esophagitis is uncommon and mostly documented in case report. It is possible that these cases are mostly unnoticed due to initial consideration of common and more serious problems. Thus, patients may be assumed to be having a severe episode of acid reflux, and it is not routinely reported or recognized. In this case series, we presented 8 patients with clindamycin-induced esophagitis. The initial presentation of all patients was odynophagia, which appeared within the first day of taking the antibiotic. All patients were subjected to endoscopic examination and ulcer was found in all cases, in the form of localized solitary or multiple ulcers with sharply defined borders. Patients were treated with proton pump inhibitor and sucralfate, and the symptoms subside within 1 week. Patient education regarding the proper way of ingesting drug seems to be the key factor in the prevention of pill-induced esophagitis. The prevention of esophagitis is even more important with antibiotics as adverse effect would decrease the patient compliance in completing the regimen and would ultimately increase antibiotic resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clindamycin-Induced Esophageal Injury: Is It an Underdiagnosed Entity?

Bestari

Agustanti

Abdurachman

2019

Clin Med Insights Case Rep

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“…Once the diagnosis of esophageal transection is confirmed, conservative management of the condition with reversal of anticoagulation, parenteral nutrition and analgesia should be undertaken (6,7). Spontaneous complete recovery of the mucosal tear and absorption of hematoma usually takes 1-3 weeks.…”

Section: Discussionmentioning

confidence: 99%

Esophageal transection

Özçınar¹,

Peker²,

Demirel³

et al. 2016

UCD

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“…Numerous medications are known to be associated with esophageal pathology through a variety of mechanisms (Table 1). Anatomic and motility disorders, as well as pill‐specific factors including contact time, coating materials, and sustained release formulations, may influence toxicity and predispose to injury 18. Elderly patients may be especially susceptible to the combined interactions between antiplatelet therapy and these commonly prescribed or over‐the‐counter medications.…”

Section: Discussionmentioning

confidence: 99%