Esophageal contractions, bolus transit and perception of transit after swallows of liquid and solid boluses in normal subjects

Dalmazo, Juciléia; Aprile, Lilian Rose Otoboni; Dantas, Roberto Oliveira

doi:10.1590/s0004-28032012000400004

Cited by 12 publications

(15 citation statements)

References 16 publications

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“…We were predominantly interested in parameters that could be quantified based on units of time, area, distance, volume, etc., rather than using Likerttype scale measures. Numerous bolus flow parameters meeting this requirement have been described in the human VFSS literature, such as oral transit time [27][28][29] , pharyngeal transit time [27][28][29][30][31][32][33] , and esophageal transit time [34][35][36] , to name but a few. Bolus transport through the oral cavity was not readily visible in mice, likely due to the small bolus size during spontaneous drinking.…”

Section: Discussionmentioning

confidence: 99%

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

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Braun

Brooks

et al. 2015

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This study adapted human videofluoroscopic swallowing study (VFSS) methods for use with murine disease models for the purpose of facilitating translational dysphagia research. Successful outcomes are dependent upon three critical components: test chambers that permit self-feeding while standing unrestrained in a confined space, recipes that mask the aversive taste/odor of commercially-available oral contrast agents, and a step-by-step test protocol that permits quantification of swallow physiology. Elimination of one or more of these components will have a detrimental impact on the study results. Moreover, the energy level capability of the fluoroscopy system will determine which swallow parameters can be investigated. Most research centers have high energy fluoroscopes designed for use with people and larger animals, which results in exceptionally poor image quality when testing mice and other small rodents. Despite this limitation, we have identified seven VFSS parameters that are consistently quantifiable in mice when using a high energy fluoroscope in combination with the new murine VFSS protocol. We recently obtained a low energy fluoroscopy system with exceptionally high imaging resolution and magnification capabilities that was designed for use with mice and other small rodents. Preliminary work using this new system, in combination with the new murine VFSS protocol, has identified 13 swallow parameters that are consistently quantifiable in mice, which is nearly double the number obtained using conventional (i.e., high energy) fluoroscopes. Identification of additional swallow parameters is expected as we optimize the capabilities of this new system. Results thus far demonstrate the utility of using a low energy fluoroscopy system to detect and quantify subtle changes in swallow physiology that may otherwise be overlooked when using high energy fluoroscopes to investigate murine disease models.

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Section: Discussionmentioning

confidence: 99%

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Lever

Braun

Brooks

et al. 2015

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“…A hipótese é que homens e mulheres têm diferenças na motilidade do esôfago. Métodos -Manometria de alta resolução foi realizada em voluntários saudáveis, 10 homens [média de idade: 37,7 (8,1) anos] e 12 mulheres [média de idade: 38,7 (7,5) anos], na posição sentada e com 10 deglutições de 5 mL de solução salina. Foram avaliadas a pressão integrada de relaxamento do esfíncter inferior do esôfago, velocidade da contração peristáltica, integral da contração distal, latência distal, extensão da contração proximal, duração da contração proximal >30 mmHg, duração da contração proximal, integral da contração proximal, pressão máxima do esfíncter superior do esôfago.…”

Section: Author' Contributionsunclassified

“…Esophageal motility has the influence of body position (2,4,6,10,12) and the characteristics of the swallowed bolus (2,5,6,10) , and may also have the influence of gender.…”

Section: Introductionmentioning

confidence: 99%

Esophageal Motility in Men and Women Evaluated by High-Resolution Manometry

Costa

Dantas

2017

Arq. Gastroenterol.

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-Background -Esophageal motility has been described in the literature as having differences between men and women. Most of these investigations use the water perfusion method for esophageal manometry. In this investigation the esophageal motility of men and women was compared with high-resolution manometry of the esophagus. Objective -To compare the esophageal motility of men and women with the high-resolution manometry method for esophageal manometry, performed in the sitting position. The hypothesis was that men and women have differences in esophageal motility. Methods -High-resolution manometry was performed in normal volunteers, 10 men [mean age: 37.5 (8.1) years] and 12 women [mean age: 38.7 (7.5) years], in the sitting position and with 10 swallows of a 5 mL bolus of saline, with an interval of at least 30 seconds between consecutive swallows. We evaluated the integrated relaxation pressure of the lower esophageal sphincter, contraction front velocity, distal contraction integral, distal latency, proximal contraction extension, proximal contraction duration >30 mmHg, proximal contraction duration, proximal contraction integral and maximal upper esophageal sphincter pressure. Results -There was no significant difference between men and women in the variables measured. Conclusion -There was no difference in esophageal motility of men and women evaluated by the high resolution manometry method, in the sitting position with swallows of a liquid bolus. HEADINGS -Gastrointestinal motility. Manometry, methods. Sex factors.

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“…Swallowing a solid bolus causes an increase in amplitude of contractions and a longer bolus transit through the esophageal body compared to swallows of a liquid bolus (5,10,11,18) . An increase in bolus viscosity causes a slowing of peristaltic contraction propagation (8) , a longer bolus transit (16) and an increase in contraction duration (8,9) , without alteration of contraction amplitude (9) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Swallowed Bolus Viscosity and Body Position on Esophageal Transit, Contraction and Perception of Transit

Dalmazo

Aprile

Dantas

2015

Arq. Gastroenterol.

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-Background -The esophagus has a different response in relation to the characteristics of a swallowed bolus. Bolus viscosity and body position may affect esophageal contraction and transit. Objective -To investigate the effect of bolus viscosity and body position on esophageal contraction, transit and perception. Methods -Esophageal contraction, transit and perception of transit were evaluated in 26 asymptomatic volunteers, 13 men and 13 women aged 18-60 years, mean: 33.6 (12.2) years. Esophageal contraction (manometry) and transit (impedance) were measured with a solid state catheter with sensors located 5, 10, 15, and 20 cm from the lower esophageal sphincter. Each volunteer swallowed in duplicate and in random sequence a 5 mL low viscous (LV) liquid bolus of an isotonic drink with pH 3.3, and a 5 mL high viscous (HV) paste bolus, which was prepared with 7.5 g of instant food thickener diluted in 50 mL of water (pH: 6.4). Results -Total bolus transit time, in the sitting position, was longer with the HV bolus than with the LV bolus. Esophageal transit was longer in the supine position than in the sitting position. Bolus head advance time was longer with the HV bolus than with the LV bolus in both positions. Contraction esophageal amplitude was higher in the supine position than in the sitting position. The perception of bolus transit was more frequent with the HV bolus than with the LV bolus, without differences related to position. Conclusion -The viscosity of the swallowed bolus and body position during swallows has an influence on esophageal contractions, transit and perception of transit.

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Esophageal contractions, bolus transit and perception of transit after swallows of liquid and solid boluses in normal subjects

Cited by 12 publications

References 16 publications

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Esophageal Motility in Men and Women Evaluated by High-Resolution Manometry

Effect of Swallowed Bolus Viscosity and Body Position on Esophageal Transit, Contraction and Perception of Transit

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