Esophageal Carcinosarcoma and Pseudosarcoma

McCort, James J.

doi:10.1148/102.3.519

Cited by 35 publications

(12 citation statements)

References 22 publications

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“…The review described by McCort [14] concluded that the prognosis is more favorable for carcinosarcoma than for SCC. Xu et al [9] reported that the carcinomatous component of the tumor is usually at an early stage at the time of diagnosis and that the incidence of lymph node metastasis is thus low.…”

Section: Discussionmentioning

confidence: 99%

Rapidly Growing Esophageal Carcinosarcoma Reduced by Neoadjuvant Radiotherapy Alone

Ogasawara

Tamura

Funaki

et al. 2014

Case Rep Gastroenterol

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Esophageal carcinosarcoma is a rare malignant neoplasm consisting of both carcinomatous and sarcomatous components. It is generally treated by surgery, radiotherapy and chemotherapy according to the protocols used for other esophageal cancers. However, the treatment of esophageal carcinosarcoma by radiotherapy alone before surgery has not been previously described. We report a patient with a rapidly growing esophageal carcinosarcoma that was efficiently reduced by neoadjuvant radiotherapy alone. A previously healthy 69-year-old man was admitted with dysphagia. Initial esophagogastroduodenoscopy (EGD) revealed a small nodular polypoid lesion of about 10 mm in the middle esophagus. A second EGD 1 month later showed that the tumor had expanded into a huge mass. A biopsy specimen revealed that the tumor comprised squamous cell carcinoma with spindle cell components, and the tumor was diagnosed as carcinosarcoma which was diagnosed as stage I (T1bN0M0). Due to renal dysfunction, the patient was treated with neoadjuvant radiotherapy (40 Gy) without chemotherapy. A third EGD 1 month later revealed remarkable tumor reduction. He then underwent total esophagectomy with regional lymph node dissection (pStage 0, pT1aN0M0). After surgical operation, the patient was followed up without adjuvant therapy. Whole body computed tomography revealed lung metastasis 14 months after surgery, and the patient died 2 months later. The neoadjuvant radiotherapy for esophageal carcinosarcoma was considered to have contributed to the subsequent surgery and his prolonged survival time. Thus, radiotherapy alone might be a suitable neoadjuvant therapy for esophageal carcinosarcomas.

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Section: Discussionmentioning

confidence: 99%

Rapidly Growing Esophageal Carcinosarcoma Reduced by Neoadjuvant Radiotherapy Alone

Ogasawara

Tamura

Funaki

et al. 2014

Case Rep Gastroenterol

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“…McCort [12] concluded in his review that carcinosarcoma has a more favorable prognosis compared to squamous cell carcinoma. Xu et al [13] reported that the carcinomatous component of the tumor is usually at an early stage at the time of diagnosis and the incidence of lymph node metastasis is thus low.…”

Section: Discussionmentioning

confidence: 99%

True Carcinosarcoma of the Esophagus: Report of a Case

Yamamoto

Watanabe

Horiuchi

et al. 2008

Case Rep Gastroenterol

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Carcinosarcoma of the esophagus is a malignant neoplasm involving both carcinomatous and sarcomatous components. We report a patient with true esophageal carcinosarcoma who underwent laparoscopy-assisted surgery. An upper gastrointestinal barium study revealed a lobulated intraluminal filling defect in the lower intrathoracic esophagus. The patient underwent esophagectomy and regional lymphadenectomy with gastric tube reconstruction by laparoscopy-assisted surgery and thoracotomy. The esophageal hiatus was entered and the mediastinal esophagus was dissected using a laparoscopic approach. Microscopically, the tumor comprised poorly differentiated squamous cell carcinoma and spindle-shaped cells resembling leiomyosarcoma. Immunohistochemically, spindle-shaped sarcomatous cells displayed strongly positive reaction to vimentin and negative reaction to cytokeratin AE1/AE3 and CD68. No transitional zone was seen between sarcomatous and carcinomatous elements. The patient was finally diagnosed with true esophageal carcinosarcoma. Laparoscopic transhiatal esophagectomy seems to be a rational and safe procedure for lower esophageal neoplasms, even for patients with impaired respiratory function.

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“…No passado acreditava-se que os carcinossarcomas e pseudo-sarcomas eram duas entidades distintas. O termo carcinossarcoma era utilizado para os tumores que continham uma verdadeira mistura de elementos carcinomatosos e sarcomatosos, e que ambos os componentes poderiam fornecer metástases para linfonodos regionais ou estruturas distantes (1,11,12) . Por outro lado, os pseudo-sarcomas eram vistos como tumores compostos essencialmente por células fusiformes "sarcoma-like" com áreas adjacentes de CEC, dispostos lado a lado, sem haver a mistura das células.…”

Section: Discussionunclassified

Carcinoma de células fusiformes de esôfago: relato de caso e revisão da literatura

Yanaga¹,

Ledesma²,

Althoff³

et al. 2003

Radiol Bras

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Lesões malignas do esôfago, excluindo-se carcinomas escamocelulares e adenocarcinomas, são bastante incomuns. Os autores relatam um caso de carcinoma de células fusiformes de esôfago. É um tumor maligno raro caracterizado por volumosa massa lobulada no terço médio do esôfago, que causa relativamente pequena obstrução apesar do seu volume. Em seguida é apresentada revisão da literatura sobre o assunto.

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Esophageal Carcinosarcoma and Pseudosarcoma

Cited by 35 publications

References 22 publications

Rapidly Growing Esophageal Carcinosarcoma Reduced by Neoadjuvant Radiotherapy Alone

Rapidly Growing Esophageal Carcinosarcoma Reduced by Neoadjuvant Radiotherapy Alone

True Carcinosarcoma of the Esophagus: Report of a Case

Carcinoma de células fusiformes de esôfago: relato de caso e revisão da literatura

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