Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report

Tamura, Hiromi; Saiki, Hirotsugu; Amano, Takahiro; Yamamoto, Masashi; Hayashi, Shiro; Ando, Hiroka; Doi, Ryohei; Nishida, Tsutomu; Yamamoto, Katsumi; Adachi, Shiro

doi:10.3748/wjg.v23.i21.3928

Cited by 9 publications

(7 citation statements)

References 14 publications

(13 reference statements)

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“…So, true esophageal submucosal gland duct adenocarcinoma is extremely rare [45]. Most of these cases possibly originate from squamous epithelium [51,52]. At present, these esophageal cancers with significant SMG duct differentiation have not been comprehensively analyzed, and differential diagnosis relies on exclusive method.…”

Section: Othersmentioning

confidence: 99%

Submucosal gland neoplasms of the esophagus: an update and review

Nie

Xue

et al. 2020

Esophagus

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Submucosal glands (SMGs) present throughout human esophagus with clusters at either the upper third or lower third of the organ. SMGs tend to atrophy with age, and neoplasms arising in these glands are rare. In order to bring convenience to diagnosis, we summarize the histopathologic characteristics of all esophageal submucosal gland tumors (SGTs). Due to the morphological similarity, the nomenclature of salivary tumors is adopted for SGTs. However, there is great confusion about the definition and histogenesis of these tumors, especially the malignant subtypes. In the literature, esophageal mucoepidermoid carcinoma and adenoid cystic carcinoma usually adjoin the surface squamous epithelium and coexist with intraepithelial neoplasia or invasive squamous cell carcinoma (SCC). In addition, the typical gene alterations of salivary tumors have not been reported in these SGTs. Therefore, we propose to apply stringent diagnostic criteria to esophageal SGTs so as to exclude mimickers that are SCCs with various degree of SMG differentiation.

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Section: Othersmentioning

confidence: 99%

Submucosal gland neoplasms of the esophagus: an update and review

Nie

Xue

et al. 2020

Esophagus

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“…Esophageal submucosal glands (SMGs) reside within the submucosal layer of the esophagus (Nie et al 2016). Esophageal submucosal gland duct adenoma (ESGDA), an extremely rare type of esophageal adenocarcinoma, originates from esophageal submucosal gland duct (ESGD) and exhibits similar, while different histological and immunohistochemical features compared to Barrett's-associated adenocarcinoma and salivary gland-type carcinoma (Tamura et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…To date, a limited number of esophageal submucosal gland duct adenocarcinoma (ESGDAC) cases have been reported. The most signi cant histological feature of ESGDAC is the double layers of cells in structure (including CK7-positive luminal cells and p63-positive basal cells), indicating esophageal gland duct differentiation (Tamura et al 2017). Due to the similarity of histopathological and immunohistochemical characteristics, ESGDAC is mainly misdiagnosed as other adenocarcinomas, containing a bi-layered adenocarcinomatous element, such as basaloid squamous cell carcinoma and salivary gland-type adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Whole-Exome Sequencing of Esophageal Submucosal Gland Duct Adenocarcinoma

Zhu

Qin

Wang

et al. 2021

Preprint

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Purpose Esophageal submucosal gland duct adenocarcinoma (ESGDAC) is an extremely rare histological variant of esophageal epithelial malignant tumors. To date, only few cases of ESGDAC have been reported. No comprehensive molecular analysis of ESGDAC has been conducted. This study focusses on the whole-exome sequencing (WES) to identify somatically acquired mutations and signatures of somatic mutations in ESGDAC. Methods Immunohistochemical analysis and whole-exome sequencing (WES) was performed in 3 ESGDAC genomes.Results In this study, we summarized the clinical, pathological, and immunohistochemical characteristics of patients with ESGDAC, we first performed whole-exome sequencing (WES) to summarize WES coverage statistics for each patient. We also examined cancer predisposition genes, ESGDAC-associated driver genes, and significantly mutated genes (SMGs). WES revealed TP53 as a SMG in ESGDAC. Conclusion We studied the tumor mutation profiling for the development of future targeted therapies for ESGDAC.

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“…EC is a common malignant tumor that originates from esophageal mucosa epithelium. [6] The cancer cells gradually enlarge and invade the muscular layer, developing up and down along the esophagus, all around the lumen and in and out both directions, with varying degrees of esophageal obstruction. [7] Advanced cancer penetrates the esophageal wall and invades the mediastinum or pericardium.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of radiation prior to surgery and chemotherapy on survival of esophageal cancer undergoing surgery

Zhang

Zhang²

2019

Medicine

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Esophageal cancer (EC) is one of the most common cancers in the world, with continuously growing diagnoses and morbidity. Because it is still unclear how to choose the best treatment for EC patients, a multimodal treatment is necessary to improve the prospect of the malignancy, including a sequence of surgery, chemotherapy, and radiotherapy, whether alone or combination. Therefore, this paper aims to analyze the effect of the sequence of chemotherapy, radiotherapy, and surgery on the prognosis and survival rate of patients with EC.The Surveillance, Epidemiology, and End Results (SEER) database was used to extract a dataset of patients who were diagnosed with EC from 1973 to 2015, with follow-up data for 6 years after diagnosis. The data were analyzed using correlation analysis, logistic regression Cox regression, and Kaplan–Meier analysis.EC patients who had radiation prior to surgery and chemotherapy had a better prognosis than the cases without chemotherapy. Based on univariate logistic regression, the odds radios of vital status recoded for “radiation prior to surgery combined with chemotherapy” is the lowest one among the 8 groups classified by radiation sequence with surgery and chemotherapy (P < .001). Further, radiation prior to surgery and chemotherapy is an independent prognostic factor for better survival among EC patients.In conclusion, in the treatment of EC, administering radiation prior to surgery and chemotherapy is better than no radiotherapy, perioperative radiotherapy, postoperative radiotherapy, and other combinations without chemotherapy.

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Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report

Cited by 9 publications

References 14 publications

Submucosal gland neoplasms of the esophagus: an update and review

Submucosal gland neoplasms of the esophagus: an update and review

Whole-Exome Sequencing of Esophageal Submucosal Gland Duct Adenocarcinoma

Long-term effects of radiation prior to surgery and chemotherapy on survival of esophageal cancer undergoing surgery

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