Esophageal Carcinoma

Zhan, Qimin; Wang, Lühua; Song, Yongmei; Ou, Yunwei; Jiang, Jing; Fan, Jing; Wang, Jingbo; Shen, Jie

doi:10.1016/b978-0-12-397833-2.00018-2

Cited by 3 publications

(2 citation statements)

References 154 publications

(84 reference statements)

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“…Moreover, the transition through the S phase is also governed by cyclin A/cdk2 [42]. Cyclin B1 is a crucial factor in regulating the transition from the G2 phase to the M phase [43,44]. This investigation found that the expression of cell-cycle-related genes was downregulated in CCL13 cells under SMG conditions.…”

Section: Discussionmentioning

confidence: 96%

Changes in the Cell Division of Chang Liver Cells Induced by Simulated Microgravity

et al. 2023

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Background: Simulated microgravity (SMG) has not been well characterized in terms of its impact on cell division structures. This research aimed to assess the changes in cell division in Chang liver cells (CCL-13 cells) under SMG conditions. Methods: CCL-13 cells were exposed to SMG conditions via a 3D clinostat for 72 h. The cells from the control group were kept under the same conditions, without exposure to SMG. The changes in cell division were assessed via cell cycle progression analysis, the transcript expression of the genes associated with the cell cycle, and the appearance of the contractile ring, microvilli, and spindle in CCL-13 cells. Results: The CCL-13 cells from both the control group and the SMG group exhibited a typical epithelial-like shape. The CCL-13 cells of both groups displayed normal nuclear morphologies and were devoid of fragmentation and condensation, which are signs of apoptosis. There were changes in the cell cycle of CCL-13 cells in the SMG condition, which were shown via an increase in the cell percentage in the G0/G1 phase and a decrease in the S phase and G2/M phase. The cell area of the SMG-exposed CCl-13 cells increased, while their nuclear area decreased, which led to a reduction in the nuclear/cytoplasmic ratio. Moreover, the transcript expression of cyclin b1, cyclin d1, cdk2, and cdk6 was downregulated in CCL-13 cells under SMG conditions compared to the control group. Interestingly, SMG-exposed CCL-13 cells exhibited a decreased appearance of microvilli, changes in the formation of the contractile ring, and polar spindle microtubules during cytokinesis. Conclusions: SMG attenuated the cell division of CCL-13 cells by driving cells into the arrest phase and altering the cell division structures.

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Section: Discussionmentioning

confidence: 96%

Changes in the Cell Division of Chang Liver Cells Induced by Simulated Microgravity

et al. 2023

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“…The miRNAs identified are shown to play important roles in this oomycete. One of the targets identified was cyclin B1, a key component in cell cycle progression from G2 to M phase, which bears implications in tumorigenesis and malignancy development [ 19 ]. Another important target CAM5 (Calmodulin 5) gene regulates many enzymes, ion channels, and other proteins through calcium pathway mediated signal transduction [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Novel MicroRNAs and their Functional Targets from Phytophthora infestans and Phytophthora cinnamomi

Varghese

Ravisankar

Mathew

2022

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Background: Even though miRNAs play viral roles in developmental biology by regulating the translation of mRNAs, they are poorly studied in oomycetes, especially in plant pathogen Phytophthora. Objective: The study was aimed to predict and identify the putative miRNAs and their targets in Phytophthora infestans and Phytophthora cinnamomi. Methods: Homology based comparative method was used to identify the unique miRNA sequences in P. infestans and P. cinnamomi with 148,689 EST and TSA sequences of these species. Secondary structure prediction of sRNAs for the 76 resultant sequences has been performed with MFOLD tool and their targets were predicted using psRNAtarget. Result: Novel miRNAs, miR-8210 and miR-4968 were predicted from P. infestans and P. cinnamomi, respectively along with their structural features. The newly identified miRNAs were identified to play important roles in gene regulation, with few of their target genes predicted as transcription factors, tumor suppressor genes, stress responsive genes, DNA repairing genes etc. Conclusion: The miRNAs and their targets identified have opened new interference and editing targets for the development of Phytophthora resistant crop varieties.

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Recent Advancements in Microbiome–Immune Homeostasis and their Involvement in Cancer Immunotherapy

Konatala

Parackel

Pola

2021

Microbiome in Human Health and Disease

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Esophageal Carcinoma

Cited by 3 publications

References 154 publications

Changes in the Cell Division of Chang Liver Cells Induced by Simulated Microgravity

Changes in the Cell Division of Chang Liver Cells Induced by Simulated Microgravity

Novel MicroRNAs and their Functional Targets from Phytophthora infestans and Phytophthora cinnamomi

Recent Advancements in Microbiome–Immune Homeostasis and their Involvement in Cancer Immunotherapy

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