1973
DOI: 10.1093/jnci/51.1.7
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Esophageal Cancer in the Transkei: 1955–69 2

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Cited by 61 publications
(16 citation statements)
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“…The corresponding incidence data for Centane for 1996-2000 were 44.8 and 32.6 per 100 000 for males and females, respectively. These data can be compared with data from 1955 to 1959, in which male and female incidence rates were 2.6 and 1.8 per 100 000 in Bizana and 54.2 and 30.3 per 100 000 in Centane (Rose 1973). Thus, rates in Centane have remained consistently high, whereas rates in Bizana have been steadily increasing.…”
Section: Resultsmentioning
confidence: 99%
“…The corresponding incidence data for Centane for 1996-2000 were 44.8 and 32.6 per 100 000 for males and females, respectively. These data can be compared with data from 1955 to 1959, in which male and female incidence rates were 2.6 and 1.8 per 100 000 in Bizana and 54.2 and 30.3 per 100 000 in Centane (Rose 1973). Thus, rates in Centane have remained consistently high, whereas rates in Bizana have been steadily increasing.…”
Section: Resultsmentioning
confidence: 99%
“…Rose, 35 using the Bantu Cancer Registry, reported that the Lusikisiki and Bizana districts in northeast Transkei had lower incidence rates (8/100 000 and 3/100 000, respectively) than the southwestern districts, of Butterworth and Centane, which had incidences of 103/100 000 and 54/100 000, respectively. 35 The earlier studies that associated HPV with 30% of cases of oesophageal cancer in South Africa used immuno -histochemistry. 20 Subsequent studies have reported prevalence rates ranging between 17% and 71%, 3 28 29 32 supporting the notion that HPV infection may be an integral part of a multistep process leading to oesophageal cancer in high risk areas.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, an investigation of the disease in different locales is necessary to fully elucidate the mechanism of the disease pathogenesis. High incidences of esophageal cancer have been noted in certain parts of China, Iran, Iraq, South America, France, Italy, and East and Southern Africa [4][5][6]. In South Africa, the Eastern Cape Province and Transkei region is recognized as being the second highest risk area for esophageal cancer in the world after the Hunan Province in China, with age standardized incidence rates of 50 per 100 000 population [7,8].…”
Section: Introductionmentioning
confidence: 99%