Esophageal Atresia and Tracheoesophageal Fistula

Holder, Thomas M.; Cloud, Daniel T.; Lewis, James E.; Pilling, George P.

doi:10.1542/peds.34.4.542

Cited by 213 publications

(10 citation statements)

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“…Anastomotic leakage into the mediastinum occurs in 14% to 21% of infants who have undergone a surgical EA repair. Leaks result from the small, friable lower segment, ischemia of the esophageal ends, excess anastomotic tension [9], sepsis, poor suturing techniques, type of suture [10, 11], excessive mobilization of the distal pouch [12], and increased gap length [9, 11] To minimize the incidence of anastomosis leak, fibrin glue was tried based on studies of different sites that have indicated that fibrin glue enhances wound healing [13, 14]. In the present series, the overall incidence of anastomotic leak was 26.6%, which is comparable to that of other reported series [7, 8], although in our series we selected only cases where the gap between the two esophageal pouches was ≥ 2 cm (long‐gap cases [10]).…”

Section: Discussionmentioning

confidence: 99%

Role of Fibrin Glue as a Sealant to Esophageal Anastomosis in Cases of Congenital Esophageal Atresia with Tracheoesophageal Fistula

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Role of Fibrin Glue as a Sealant to Esophageal Anastomosis in Cases of Congenital Esophageal Atresia with Tracheoesophageal Fistula

et al. 2007

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“… 7 , 8 Congenital BEF is mostly found in childhood and is very rare in adults. 9 There have been reports of BEF due to esophageal tuberculosis, 10 and recently, BEF has been reported in patient with coinfection of severe acute respiratory syndrome coronavirus 2 and tuberculosis. 11 In patients with CD, there have been some cases of BEF due to esophageal involvement, 12 although esophageal involve ment in CD is rare and is reportedly difficult to diagnose.…”

Section: Discussionmentioning

confidence: 99%

Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy

Choi

Kim

et al. 2023

Clin Endosc

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Tuberculosis is an adverse event in patients with Crohn’s disease receiving anti-tumor necrosis factor (TNF) therapy. However, tuberculosis presenting as a bronchoesophageal fistula (BEF) is rare. We report a case of tuberculosis and BEF in a patient with Crohn’s disease who received anti-TNF therapy. A 33-year-old Korean woman developed fever and cough 2 months after initiation of anti-TNF therapy. And the symptoms persisted for 1 months, so she visited the emergency room. Chest computed tomography was performed upon visiting the emergency room, which showed BEF with aspiration pneumonia. Esophagogastroduodenoscopy with biopsy and endobronchial ultrasound with transbronchial needle aspiration confirmed that the cause of BEF was tuberculosis. Anti-tuberculosis medications were administered, and esophageal stent insertion through endoscopy was performed to manage the BEF. However, the patient’s condition did not improve; therefore, fistulectomy with primary closure was performed. After fistulectomy, the anastomosis site healing was delayed due to severe inflammation, a second esophageal stent and gastrostomy tube were inserted. Nine months after the diagnosis, the fistula disappeared without recurrence, and the esophageal stent and gastrostomy tube were removed.

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“…A neural tube fails to close and causes spina bifida; 1 an esophagus errantly connects into the windpipe and produces esophageal atresia. 3 Since the revolutionary discovery of the structure of DNA by Watson and Crick in 1953, 4 scientists have primarily worked to characterize the biochemical signals that underlie tissue assembly in the embryo. 1 This important work has helped elucidate the vast signaling and gene regulatory networks that pattern the early embryo and drive the differentiation of organspecific cell types.…”

Section: Introductionmentioning

confidence: 99%

Let's push things forward: disruptive technologies and the mechanics of tissue assembly

Varner

Nelson

2013

Integr. Biol.

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Although many of the molecular mechanisms that regulate tissue assembly in the embryo have been delineated, the physical forces that couple these mechanisms to actual changes in tissue form remain unclear. Qualitative studies suggest that mechanical loads play a regulatory role in development, but clear quantitative evidence has been lacking. This is partly owing to the complex nature of these problems – embryonic tissues typically undergo large deformations and exhibit evolving, highly viscoelastic material properties. Still, despite these challenges, new disruptive technologies are enabling study of the mechanics of tissue assembly in unprecedented detail. Here, we present novel experimental techniques that enable the study of each component of these physical problems: kinematics, forces, and constitutive properties. Specifically, we detail advances in light sheet microscopy, optical coherence tomography, traction force microscopy, fluorescence force spectroscopy, microrheology and micropatterning. Taken together, these technologies are helping elucidate a more quantitative understanding of the mechanics of tissue assembly.

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Esophageal Atresia and Tracheoesophageal Fistula

Cited by 213 publications

References 0 publications

Role of Fibrin Glue as a Sealant to Esophageal Anastomosis in Cases of Congenital Esophageal Atresia with Tracheoesophageal Fistula

Role of Fibrin Glue as a Sealant to Esophageal Anastomosis in Cases of Congenital Esophageal Atresia with Tracheoesophageal Fistula

Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy

Let's push things forward: disruptive technologies and the mechanics of tissue assembly

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