Esomeprazole With Clopidogrel Reduces Peptic Ulcer Recurrence, Compared With Clopidogrel Alone, in Patients With Atherosclerosis

Hsu, Ping‐I; Lai, Kwok‐Hung; Liu, Chun–Peng

doi:10.1053/j.gastro.2010.11.056

Cited by 84 publications

(66 citation statements)

References 20 publications

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“…As far as the inhibition of the CYP 2C19 by the PPI is reversible and considering the short half-life of the PPI, some authors suggested minimizing the clinical consequences of this interaction by prescribing the PPI in the morning and the clopidogrel in the evening with an interval of 12 hours by separating both the takings [55]. However, the published randomized forward-looking studies did not find this interaction and confirmed the beneficial effects of the PPI on the digestive bleedings [31,56,57,58]. In 2012, these data allowed Afssaps (become ANSM: National agency of Safety of the Medicine) to remove, the PPI-clopidogrel interaction from the thesaurus of the medicinal interactions [59].…”

Section: Esophageal Abnormalitiesmentioning

confidence: 99%

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Boudabous¹,

Gdoura²,

Mnif³

et al. 2017

Esophageal Abnormalities

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The proton-pump inhibitor (PPI) is an effective and widely used treatment but may cause side effects, especially for the elderly. Materials and methods: this is a cross-sectional study including 45 patients older than 65 years, followed at our outpatient and treated with PPIs for at least a year. The indication for PPI, the results of any endoscopy, and the quality of the tolerance of these molecules is specified by the data folder. During the consultation, we conducted an interrogation to an update of the history and medications to our patients and a type checking of the molecule, the dose, and the quality of the observance. Results: patients were divided into 32 women and 13 men with a mean age of 75 ± 7 years (65-92). The average length of PPI use was 6 ± 4 years (1-16) with a consumption of a double dose for at least 1 year in 28.8% of cases. The prescribed dose was higher than the recommended dose in at least 15.5% of cases. PPIs were well tolerated. One patient had presented a microscopic colitis, revealed by diarrhea regressed after discontinuation of PPIs. Conclusion: PPIs were prescribed in elderly subjects by gastroenterologists, in a university center, with a high dose and long. In our series, this treatment is well tolerated in the elderly.

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Section: Esophageal Abnormalitiesmentioning

confidence: 99%

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Boudabous¹,

Gdoura²,

Mnif³

et al. 2017

Esophageal Abnormalities

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“…However, evidence on the increased risk of GIB and even ulcerogenic effects of clopidogrel has been reported [8,9]. Newer and more potent P2Y12 antagonists, such as prasugrel and ticagrelor, have similar or even a higher risk of GIB [10].…”

Section: Anti-platelet Drugs and Gi Complicationmentioning

confidence: 99%

How do we manage serious gastrointestinal adverse events associated with anti-thrombotic therapy?

Sugano

2014

Expert Review of Gastroenterology & Hepatology

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“…Studies have reported an increased risk in upper gastrointestinal bleeding complications due to dual therapy compared to the same dose of aspirin alone or clopidogrel alone (Diener et al 2004;Hsu et al 2011). Antiplatelet therapy is correlated with various hemorrhagic complications, and upper gastrointestinal bleeding is the most frequent bleeding site (Trenk 2009).…”

Section: Roles In Prevention Of Atherothrombosismentioning

confidence: 99%

“…The PRI did not significantly change in the pantoprazole group leading the authors to conclude that an interaction between clopidogrel and omeprazole exists but not pantoprazole . Esomeprazole is the S-isomer omeprazole which is assumed to have similar metabolic pathways and effects as omeprazole (Richter et al 2001;), although studies have not been able to provide consistent effects of esomeprazole treatment on clopidogrel's antiplatelet efficacy (Siller-Matula et al 2009;Neubauer et al 2010;Fernando et al 2011;Hsu et al 2011). …”

Section: In Vitro Studies On Clopidogrel-ppi Interactionmentioning

confidence: 99%

“…Details of some of these studies are provided below (Table 2). Despite a concern on the antiplatelet effects of clopidogrel related to PPIs, several studies suggested that PPIs and H2RA are associated with a reduction in the risk of upper GI bleeding and recurrent peptic ulcer in CAD patients who are also taking clopidogrel and aspirin (Ng et al 2008;Bhatt et al 2010;Hsu et al 2011;. A double-blind, randomised, controlled trial suggests that esomeprazole is better than famotidine in preventing GI complications in patients taking a combination of aspirin, clopidogrel, and either enoxaparin or thrombolytics (Ng et al 2011).…”

Section: Clinical Studies On the Clopidogrel-ppi Interactionmentioning

confidence: 99%

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Impact of drug warning system on prescriptions

Niyomnaitham¹

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The emergence of a serious adverse effect from a recently marketed drug is a great concern. The earlier we can detect and evaluate those unwanted effects, the better we can prevent them. Regulatory authorities play an important role in detecting, assessing and informing healthcare professionals and consumers on drug safety issues. Regulatory authorities use drug safety warnings as a communication tool for notifying prescribers about the risk and providing the recommendation for their practices. Expected outcomes of drug safety warnings are prescribers' awareness of these risks and a change in their prescribing according to the safety information. However, effectiveness of these safety warnings on clinical practice had been reviewed and led to recommendation for reform in These results suggest that changes in patterns of concerned drugs were associated with international warnings, which may get through to Australian prescribers via NPS MedicineWise or other medical associations. In summary, the impact on drug use depends on the intensity and clarity of warnings as well as the certainty, severity and prevalence of adverse effects. This thesis expands the current understanding of the impact of regulatory iii safety warnings on prescriptions and also provides the scope for possible improvement to the warning system in Australia.iv

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Esomeprazole With Clopidogrel Reduces Peptic Ulcer Recurrence, Compared With Clopidogrel Alone, in Patients With Atherosclerosis

Cited by 84 publications

References 20 publications

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

How do we manage serious gastrointestinal adverse events associated with anti-thrombotic therapy?

Impact of drug warning system on prescriptions

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