Observations of Neptune, made in 2018 using the new Narrow Field Adaptive Optics mode of the Multi Unit Spectroscopic Explorer (MUSE) instrument at the Very Large Telescope (VLT) from 0.48 -0.93 µm, are analysed here to determine the latitudinal and vertical distribution of cloud opacity and methane abundance in Neptune's observable troposphere (0.1 -∼ 3 bar). Previous observations at these wavelengths in 2003 by HST/STIS (Karkoschka and Tomasko 2011, Icarus 205, 674-694) found that the mole fraction of methane above the cloud tops (at ∼ 2 bar) varied from ∼ 4% at equatorial latitudes to ∼ 2% at southern polar latitudes, by comparing the observed reflectivity at wavelengths near 825 nm controlled primarily by either methane absorption or H 2 -H 2 /H 2 -He collision-induced absorption. We find a similar variation in cloud-top methane abundance in 2018, which suggests that this depletion of methane towards Neptune's pole is potentially a long-lived feature, indicative of long-term upwelling at mid-equatorial latitudes and subsidence near the poles. By analysing these MUSE observations along the central meridian with a retrieval model, we demonstrate that a broad boundary between the nominal and depleted methane abundances occurs at between 20 -40 • S. We also find a small depletion of methane near the equator, perhaps indicating subsidence there, and a local enhancement near 60 − 70 • S, which we suggest may be associated with South Polar Features (SPFs) seen in Neptune's atmosphere at these latitudes. Finally, by the use of both a reflectivity analysis and a principal component analysis, we demonstrate that this depletion of methane towards the pole is apparent at all locations on Neptune's disc, and not just along its central meridian.