Esmolol and Landiolol, Selective β1-Adrenoreceptor Antagonists, Provide Neuroprotection Against Spinal Cord Ischemia and Reperfusion in Rats

Umehara, Shino; Goyagi, Toru; Nishikawa, Toshiaki; Tobe, Yoshitsugu; Masaki, Yoko

doi:10.1213/ane.0b013e3181cdb06b

Cited by 38 publications

(22 citation statements)

References 14 publications

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“…In previous studies, it has been found that esmolol shows antioxidant properties by reducing lipid peroxidation markers [13]. Esmolol has been found to reduce histological and motor disorders caused by spinal cord I/R damage and has protective effect against spinal cord I/R injury [14]. At the same time, protective efficacy has been determined in transient ischemic attacks [8].…”

Section: Lower-limb Ischemia-reperfusionmentioning

confidence: 99%

Does Esmolol Havean Effect on Erythrocyte Deformability in Rat Lower Limb İschemia Reperfusion İnjury?

Doğan¹,

Metin²,

Küçük³

et al. 2019

Int J Anesthetic Anesthesiol

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Section: Lower-limb Ischemia-reperfusionmentioning

confidence: 99%

Does Esmolol Havean Effect on Erythrocyte Deformability in Rat Lower Limb İschemia Reperfusion İnjury?

Doğan¹,

Metin²,

Küçük³

et al. 2019

Int J Anesthetic Anesthesiol

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“…The liver and kidneys were dissected totally and fixed in buffered formalin for 7 days. The experimental model was carried out according to the experimental studies in the literature that investigate the spinal cord and visceral organ damage after cross-clamping the aorta [17][18][19][20].…”

Section: Tissue Preparationmentioning

confidence: 99%

Montelukastın karaciğer ve böbrekteki iskemi/reperfüzyon hasarına olan etkisi

Budak¹,

Korkmaz²,

Gedik³

et al. 2017

TURKISH JOURNAL of CLINICS and LABORATORY

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Aim: The thoracoabdominal aortic aneurysm surgery may cause splanchnic ischemia and may result in severe postoperative complications caused by liver and/or kidney injury. This study investigated the effect of temporary occlusion of the aorta on the development of I/R injury of liver and kidney and the protective effect of montelukast, a selective reverse CysLT1 receptor antagosit. Material and Methods: Twenty-one male Sprague-Dawley rats were randomly assigned to three groups (n=7 per group) as G1 (no aortic occlusion and montelukast administration), G2 (45 min. aortic occlusion; no montelukast administration) and G3 (45 min. aortic occlusion, 10 mg/kg montelukast administration). At the 48th hour of reperfusion, kidney and liver samples were dissected for histopathological evaluation and immunohistochemical staining for HSP70, interleukin-6 and myeloperoxidase (MPO). Results: Tissue samples taken from the kidney showed significant intergroup differences in terms of tubular cell degeneration, cytoplasmic vacuole formation, hemorrhage and tubular dilatation (P = 0.001, P = 0.017, P = 0.001, P = 0.001 respectively). There was a significant difference with regards to HSP-70 stain (P = 0.01) in favor of G1 and G3 with respect to G2. Hepatocyte degeneration in the liver samples of G3 was significantly lower than that of G1 and G2 (P = 0.027). Conclusion: The findings of the current study demonstrated that montelukast has protective effects on both kidney and liver; and were confirmed histopathologically and immunohistochemically. The protective effects of montelukast can be attributed to its potential of anti-oxidative and anti-inflammatory actions.

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“…To assess the degree of ischemic neuronal injury, the number of normal motor neurons in the anterior horn of the spinal cord (anterior to a line drawn through the central canal perpendicular to the vertebral axis) was counted in 3 sections for each animal and averaged. 24 Terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining was performed following the protocol provided by the manufacturer (S7100, Millipore). Spinal cord sections were deparaffinized, rehydrated, digested with 20 mg/ml proteinase K (Sigma Chemical) for 30 minutes at room temperature, quenched with 3% hydrogen peroxide for 5 minutes at room temperature, rinsed in phosphate-buffered saline (PBS), and subsequently incubated with a reaction solution composed of 55 ml/5 cm 2 of working strength TdT enzyme under a humidified atmosphere for 60 minutes at 37°C.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

Effect of coenzyme Q10 on spinal cord ischemia-reperfusion injury

Hwang

Min

Jeon

et al. 2015

SPI

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OBJECT Spinal cord ischemia remains a serious complication of thoracoabdominal aortic aneurysm surgery. Coenzyme Q10, a potent antioxidant, has been reported to exert a neuroprotective effect. In the present study, we evaluated the effect of coenzyme Q10 pretreatment on spinal cord ischemia-reperfusion injury. METHODS Male Sprague-Dawley rats were treated with either 300 mg/kg coenzyme Q10 (CoQ10 group, n = 12) or saline (control and sham groups, n = 12 for each group) for 5 days before ischemia. Spinal cord ischemia was induced in the control and CoQ10 groups. Neurological function was assessed using the Basso-Beattie-Bresnahan (BBB) motor rating scale until 7 days after reperfusion, and then the spinal cord was harvested for histopathological examinations and an evaluation of malondialdehyde level. RESULTS On post-reperfusion Day 1, the CoQ10 group showed higher BBB scores compared with those in the control group, although the difference was not significant. However, on Day 2, the CoQ10 group showed a significantly higher BBB score than the control group (14.0 [10.3–15.0] vs 8.0 [5.0–9.8], median [IQR], respectively; p = 0.021), and this trend was maintained until Day 7 (17.5 [16.0–18.0] vs 9.0 [6.5–12.8], respectively; p < 0.001). Compared with the control group, the CoQ10 group had more normal motor neurons (p = 0.003), fewer apoptotic changes (p = 0.003) and a lower level of tissue malondialdehyde (p = 0.024). CONCLUSIONS Pretreatment with 300 mg/kg coenzyme Q10 resulted in significantly improved neurological function and preservation of more normal motor neurons.

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Esmolol and Landiolol, Selective β1-Adrenoreceptor Antagonists, Provide Neuroprotection Against Spinal Cord Ischemia and Reperfusion in Rats

Abstract: These data show that ultrashort-acting selective beta(1)-adrenoreceptor antagonists can reduce neurological injury in a rat model of spinal cord ischemia-reperfusion.

Cited by 38 publications

References 14 publications

Does Esmolol Havean Effect on Erythrocyte Deformability in Rat Lower Limb İschemia Reperfusion İnjury?

Does Esmolol Havean Effect on Erythrocyte Deformability in Rat Lower Limb İschemia Reperfusion İnjury?

Montelukastın karaciğer ve böbrekteki iskemi/reperfüzyon hasarına olan etkisi

Effect of coenzyme Q10 on spinal cord ischemia-reperfusion injury

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