ESMO Congress 2021: highlights from the EORTC gastrointestinal tract cancer group’s perspective

Koessler, Thibaud; Alsina, María; Arnold, Dirk; Ben‐Aharon, Irit; Collienne, Maike; Lutz, Manfred P.; Neuzillet, Cindy; Obermannová, Radka; Peeters, Marc; Sclafani, Francesco; Smyth, Elizabeth; Valle, Juan W.; Wagner, Anna Dorothea; Wyrwicz, Lucjan; Fontana, Elisa; Moehler, Markus

doi:10.1016/j.esmoop.2022.100392

Cited by 1 publication

(1 citation statement)

References 49 publications

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“…Furthermore, treatment with immune checkpoint inhibitors can provide significantly improved response rates or even long-lasting complete responses in some cases [118][119][120]. Even though the success of immunotherapy has been proven in multiple clinical trials, to this day, a consensus regarding the optimal scope of patients for this therapy has not been reached [121][122][123][124]. TME is considered a key to the success of immunotherapy; however, the evaluation of the immune microenvironment and its clinical implications is still a challenge, especially in NENs.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Defining Tumor Microenvironment as a Possible Target for Effective GEP-NENs Immunotherapy—A Systematic Review

Chmiel,

Rychcik-Pazyrska,

Stec

2023

Cancers

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Neuroendocrine neoplasms (NENs) are a heterogenous and recurrent group of malignancies originating from neuroendocrine secretory cells diffused on all parts of the human body. Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) account for most NENs. Considering the abundance of possible origins, locations, and tumor specifications, there is still no consensus about optimal treatment options for these neoplasms. In light of the escalating immunotherapeutic approaches, it is crucial to define indications for such therapy in GEP-NETs. Bearing in mind the significance of pathophysiological mechanisms and tumor microenvironment (TME) impact on carcinogenesis, defining TME structure and correlation with the immune system in GEP-NETs appears essential. This paper aimed to assess the characterization of the tumor immune microenvironment for a better understanding of the possible therapeutic options in GEP-NETS. The authors performed a systematic review, extracting papers from the PubMed, Web of Science, and Scopus databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Among 3800 articles identified through database searching, 292 were assessed for eligibility. Ultimately, 28 articles were included in the qualitative synthesis. This paper sums up the research on the immune cell infiltrates, immune checkpoint expression, cytokine profile, neoangiogenesis, and microbiome in the TME of GEP-NETs.

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