Eslicarbazepine acetate for the treatment of status epilepticus

Abstract

Objective: Due to the high mortality of patients with refractory status epilepticus (SE), new antiseizure medications (ASMs) are needed to improve long-term outcomes. In this study, we evaluated the efficacy and safety of eslicarbazepine acetate (ESL), a new sodium channel blocker, based on the data from a large epilepsy register.Methods: Data on the efficacy and safety of ESL for the treatment of refractory SE were gathered from the Mainz Epilepsy Registry (MAINZ-EPIREG). Logistic regression was applied to identify predictors of status interruption.Results: In total, 64 patients with remote symptomatic refractory SE were treated with ESL. No cases of idiopathic generalized epilepsy were included. The average age was 61.4 ± 11.0 years. The median number of administered ASMs before the start of ESL was three. On average, 2 days had elapsed since the onset of SE before the administration of ESL. The initial dose of 800 mg/day was increased up to a maximum daily dose of 1600 mg in case of nonresponse. In 29 of 64 patients (45.3%), the SE could be interrupted within 48 h of ESL therapy. In patients with poststroke epilepsy, the control of SE was achieved in 62% of patients (15/23). The earlier initiation of ESL therapy was an independent predictor of control of SE. Hyponatraemia occurred in five patients (7.8%). Other side effects were not observed.Significance: Based on these data, ESL may be used as an adjunct therapy for the treatment of refractory SE. The best response was found in patients with poststroke epilepsy. In addition, early initiation of ESL therapy appears to result in better control of SE. Besides a few cases of hyponatraemia, no other adverse events were detected. K E Y W O R D Sefficacy, eslicarbazepine acetate, hyponatraemia, poststroke epilepsy, safety, status epilepticus | INTRODUCTIONStatus epilepticus (SE) is a neurological emergency causing both high morbidity and mortality unless prompt and effective treatment is administered. 1 Excessive neuronal discharges lead to epileptiform potentials inducing brain damage and secondary systemic complications. Alterations at the molecular, cellular, synaptic, andThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Epilepsie-Update

“…Beim Status epilepticus infolge einer Post-Stroke-Epilepsie zeigten sich ähnliche Ergebnisse. Hier konnten die Effekte von Lacosamid, Brivaracetam, Eslicarbazepin, Perampanel, Topiramat und Zonisamid verglichen werden, und wieder zeigte sich eine Überlegenheit bezüglich des Therapieerfolg für Eslicarbazepin und Lacosamid [3,4].…”