ESKD or Cancer: Given the Choice, Which Would You Rather Have?

Polkinghorne, Kevan R.

doi:10.1053/j.ajkd.2019.01.037

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Mortality rates for patients with end-stage renal disease (ESRD) who were treated with dialysis remain unacceptably high, and the annual mortality rates range from 15 to 20% [1]. Cardiovascular disease (CVD) is the lead- ing cause of death among haemodialysis (HD) patients [2].…”

Section: Introductionmentioning

confidence: 99%

Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients

Jiang

Yin

et al. 2021

Kidney Dis

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Background: Cardiovascular disease (CVD) is the leading cause of death in haemodialysis (HD) patients. Vascular calcification (VC) is dramatically accelerated and is strongly associated with CVD events and mortality in HD patients. VC coexists with osteoporosis in many studies. Fibroblast growth factor 21 (FGF21) which is known as an adipocytokine is a new hypoglycemic strategy and is inversely related to bone mineral density. Methods: To evaluate the contribution of FGF21 to VC in HD patients, we detected circulating FGF21 levels and measured the whole thoracic aorta calcification scores (TACS) and calcification scores of the 3 segments of thoracic aorta, including ascending thoracic aorta (ATACS), aortic arch (AoACS), and descending thoracic aorta (DTACS) of our HD patients in this cross-sectional study. In addition, we pre-incubated human aortic endothelial cells (HAECs) with FGF21 in the presence or absence of parathyroid hormone (PTH) in vitro. Results: The median serum FGF21 level in HD patients was 11-fold higher than that in healthy controls. Ln(FGF21) was positively correlated with Ln(TACS+1), Ln(ATACS+1), Ln(AoACS+1), and Ln(DTACS+1), respectively, in HD patients. Serum FGF21 was independently associated with TACS and ATACS, AoACS, and DTACS. FGF21 which was combined with age, calcium, and intact PTH demonstrated a high area under the curve of 0.84 with optimal sensitivity (84%) and specificity (71%) for the prediction of VC in HD patients. Our vitro results showed that FGF21 enhanced the calcification effect of PTH on HAECs by increasing calcium deposition and endothelial-to-mesenchymal transition. Conclusions: Circulating FGF21 was notably higher and was a potential predictor and promoter of VC in HD patients.

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Section: Introductionmentioning

confidence: 99%

Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients

Jiang

Yin

et al. 2021

Kidney Dis

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“…The poorer results for hemodialysis patients may be due to the lagging development in terms of lifesaving therapies, limited research for kidney disease compared with "high profile" diseases like cancer, several barriers to transplant, and the higher complications among hemodialysis patients [79]. One author even noted that cancer research has already resulted in many therapeutic advances over the last decade and only a relatively few treatment breakthroughs in kidney disease [80].…”

Section: Quality Of Life Domainsmentioning

confidence: 99%

“…Cancer and diabetes are well recognized as significant public health issues while the contribution of kidney disease to the global burden of disease is not well recognized as evident by few countries with dedicated kidney disease prevention and control programs. Polkinghorne further cited that research for kidney disease also lags behind other diseases [80].Consequently, the results of the study call for an urgent need for well-designed policy to address the issues faced by hemodialysis patients.…”

Section: Quality Of Life Domainsmentioning

confidence: 99%

A Review of the Quality of Life of Hemodialysis, Breast Cancer, and Type 2 Diabetes Mellitus Patients

Arceo

Dizon

Salunga

et al. 2020

SN Compr. Clin. Med.

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Chronic diseases affect the overall quality of life of patients as it negatively impacts different areas in life. The review assessed and qualitatively compared the quality of life (QoL) of patients suffering from three chronic diseases namely patients undergoing hemodialysis, patients with type 2 diabetes mellitus, and patients with breast cancer. Qualitative assessment of previous studies using the Ferrans and Powers quality of life index was conducted. Nineteen (19) full texts were included and comprehensively analyzed. Statistically significant lower scores were noted on the health/functioning and socioeconomic domains of patients undergoing hemodialysis and no significant difference in other areas on the quality of life. There was also no significant difference in the overall scores among the three chronic diseases under study. But while the overall QoL of patients are within the same range, results suggest that hemodialysis patients experience the greatest negative impact in terms of socioeconomic and health/functioning domains in the QoL. Thus, health interventions, educational programs, and policy formulations should focus on improving these aspects. This would also call for a multidisciplinary approach to address the issues related to the quality of life of hemodialysis patients. Keywords Quality of life. Chronic disease. Type 2 diabetes mellitus. Breast cancer. Hemodialysis patients This article is part of the Topical Collection on Medicine

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Construction of a miR-15a -based risk prediction model for vascular calcification detection in patients undergoing hemodialysis

Fu,

Liu,

Yang

et al. 2024

Renal Failure

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ESKD or Cancer: Given the Choice, Which Would You Rather Have?

Cited by 5 publications

References 20 publications

Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients

Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients

A Review of the Quality of Life of Hemodialysis, Breast Cancer, and Type 2 Diabetes Mellitus Patients

Construction of a miR-15a -based risk prediction model for vascular calcification detection in patients undergoing hemodialysis

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