Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia

Kadakol, Almesh; Malek, Vajir; Goru, Santosh Kumar; Pandey, Anuradha; Bagal, Shreyas; Gaikwad, Anil Bhanudas

doi:10.1016/j.bbrc.2015.04.036

Cited by 32 publications

(31 citation statements)

References 31 publications

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“…Briefly, the rats were allocated to two dietary regimens: Normal control (NC); fed with normal pellet diet (NPD, n¼ 6) and insulin resistant group; fed with HFD (n ¼24) ad libitum for six weeks, respectively. Recently, we have studied Esculetin at two doses (50 and 100 mg/kg/day) against cardiovascular dysfunction associated with IR and type 2 diabetes and it showed batter cardiovascular protective effect at 100 mg/kg/day dose (Kadakol et al, 2015a(Kadakol et al, , 2015b. Hence, in the present study we have used lower dose of Esculetin (50 mg/kg/day) to evaluate its additive effect with combination of Telmisartan in prevention of IR and associated cardiac fibrosis.…”

Section: Development Of Non-genetic Animal Model For Insulin Resistanmentioning

confidence: 87%

“…Recently, we have reported that Esculetin shows cardioprotective effect by reversing post translational histone modifications associated with IR and type 2 diabetes (Kadakol et al, 2015b). We have also demonstrated that Esculetin improved vascular responsiveness and reduced the expression of Ang II receptors in thoracic aorta of hyperglycaemic and hyperinsulinemic rats (Kadakol et al, 2015a). Hence, we hypothesized that Telmisartan and Esculetin combination may be the better therapeutic approach than the individual drug treatment regimen to ameliorate IR and associated cardiovascular dysfunction.…”

Section: Introductionmentioning

confidence: 94%

“…Insulin resistance (IR) was induced by high fat diet (HFD) feeding, as per the protocol described previously (Kadakol et al, 2015a). Briefly, the rats were allocated to two dietary regimens: Normal control (NC); fed with normal pellet diet (NPD, n¼ 6) and insulin resistant group; fed with HFD (n ¼24) ad libitum for six weeks, respectively.…”

Section: Development Of Non-genetic Animal Model For Insulin Resistanmentioning

confidence: 99%

“…Insulin was estimated by ultra-sensitive rat insulin kit (Kadakol et al, 2015a(Kadakol et al, , 2015b.…”

Section: Assessment Of Insulin Resistance and Diabetesmentioning

confidence: 99%

“…Artemesia capillaries, Citrus limonia, and Euphorbia lathyris] is used in various inflammatory, allergic and infectious diseases (Chang et al, 1996;Sim et al, 2015). It has been reported to have a potent anti-oxidant (Kadakol et al, 2015a), anti-inflammatory (Kim et al, 2014) and anti-proliferative (Kim and Lee, 2015) activity. In addition, esculetin did not have any mutagenic or genotoxic effect in cultured human lymphocytes (Maistro et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis

Kadakol

Pandey

Goru

et al. 2015

European Journal of Pharmacology

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Section: Development Of Non-genetic Animal Model For Insulin Resistanmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 94%

Section: Development Of Non-genetic Animal Model For Insulin Resistanmentioning

confidence: 99%

“…Insulin was estimated by ultra-sensitive rat insulin kit (Kadakol et al, 2015a(Kadakol et al, , 2015b.…”

Section: Assessment Of Insulin Resistance and Diabetesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis

Kadakol

Pandey

Goru

et al. 2015

European Journal of Pharmacology

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Protective effects of esculetin against ovary ischemia–reperfusion injury model in rats

Güvenç,

Yüksel,

Kutlu

et al. 2023

J Biochem & Molecular Tox

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AimsOvarian ischemia–reperfusion (I/R) injury is a phenomenon that necessitates urgent intervention, which occurs as a result of ovarian torsion, and it is frequently seen in young women. A large amount of free radical and oxidative damage as a result of I/R plays a role in the cause of the incident. Antioxidant agents are thought to be beneficial in preventing this damage, and the potential protective effects of esculetin, which had not been tested previously, were investigated in this study.Study DesignThe rats in the study were divided into five groups at random: control, sham, esculetin, I/R, and treatment. Oxidative stress parameters, proinflammatory cytokines, nuclear factor erythroid 2‐related factor 2 (Nrf‐2)/nuclear factor‐kβ (NF‐κβ) pathway, and histopathological analyses were evaluated at the end of the study.Key FindingsAfter I/R, malondialdehyde levels, proinflammatory cytokines, tumor necrosis factor‐α and interleukin‐1β levels and NF‐κβ expressions were increased, Nrf‐2 expression and glutathione level decreased and the histopathologic picture deteriorated. However, as a result of the esculetin treatment, ameliorative effects in the aforementioned parameters were determined, and it was ensured that they returned to normal levels.ConclusionAccording to these findings, esculetin has protective effects on I/R damage by lowering lipid peroxidation and having antioxidant and anti‐inflammatory properties.SignificanceOur results proved the protective effect of esculetin against ovarian IR injury in rats and this may be attributed to Nrf‐2/NF‐κβ axis which showed antioxidant and anti‐inflammatory effects. Therefore, esculetin can be used in the future for preventive effects to ovarian IR injury.

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Mitochondria‐targeted esculetin inhibits PAI‐1 levels by modulating STAT3 activation and miR‐19b via SIRT3: Role in acute coronary artery syndrome

Katta

Karnewar

Panuganti

et al. 2017

Journal Cellular Physiology

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In this study we explored the microRNAs responsible for the regulation of PAI-1 during LPS-stimulated inflammation in human aortic endothelial cells and subsequently studied the effect of a newly synthesized mitochondria-targeted esculetin (Mito-Esc) that was shown for its anti-atherosclerotic potential, in modulating PAI-1 levels and its targeted miRs during angiotensin-II-induced atherosclerosis in ApoE −/− mice. LPS-stimulated PAI-1 was accompanied with an upregulation of miR-19b and down-regulation of miR-30c. These effects of LPS on PAI-1 were reversed in the presence of both parent esculetin and Mito-Esc. However, the effect

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Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia

Cited by 32 publications

References 31 publications

Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis

Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis

Protective effects of esculetin against ovary ischemia–reperfusion injury model in rats

Mitochondria‐targeted esculetin inhibits PAI‐1 levels by modulating STAT3 activation and miR‐19b via SIRT3: Role in acute coronary artery syndrome

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