ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

Beek, Diederik van de; Cabellos, Carmen; Džupová, Olga; Esposito, Susanna; Klein, Matthias; Kloek, Anne T.; Leib, Stephen L.; Mourvillier, Bruno; Østergaard, Christian Richter; Pagliano, Pasquale; Pfister, H.-W.; Read, Robert C.; Sıpahi, Oğuz Reşat; Brouwer, Matthijs C.

doi:10.1016/j.cmi.2016.01.007

Cited by 582 publications

(564 citation statements)

References 133 publications

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“…Rifampicin could also be considered as supplementary therapy together with vancomycin or linezolid. Rifampicin must not be used as monotherapy to avoid the development of resistance [38].…”

Section: Discussionmentioning

confidence: 99%

The microbiology and clinical characteristics of bacterial and fungal meningitis in a Chinese hospital

Chen¹,

Hu²,

Liu³

2017

Arch Med Sci Civil Dis

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A b s t r a c t Introduction:The aim was to investigate the distribution, antibiotic resistance, initial clinical and laboratory characteristics of pathogens isolated from the cerebrospinal fluid samples (CSF). Material and methods: The CSF were subjected for identification. The minimum inhibitory concentrations (MICs) of antimicrobial agents were tested. The initial clinical and laboratory characteristics were collected. Results: The rate of positive yield of pathogen meningitis in our study was 8.16% . Among the 1994 non-repetitive pathogens, Gram-positive pathogen was the most common (71.71%), followed by Gram-negative pathogen (20.36%), fungal (6.62%) and Mycobacterium tuberculosis (1.30%). Coagulase-negative staphylococci (CNS) was the most common Gram-positive pathogen and Acinetobacter baumannii (Ab) was the most common Gram-negative pathogen. As to fungal pathogen, Cryptococcus neoformans (CN) was the most common. The main CNS showed higher antimicrobial resistant rate for Penicillin G, oxacillin, clindamycin and erythromycin. Acinetobacter baumannii resistant to the most tested antibiotics and only showed considerable rate of resistance to cefoperazone/sulbactam, tigecycline and amikacin. All CN were susceptible to 5-fluorocytosine and only 3.6% CN were resistance to fluconazole. Long days of hospital stay, fever and meningeal irritation signs were common symptoms in the bacterial and fungal meningitis. Head injury, disturbance of consciousness, the pupil size of both eyes was not equal, pupillary reaction to light was slow or absent were more common in the Ab meningitis. The CSF protein concentration and white blood cells count as well as glucose concentration can be used in guiding initial treatment and further microbiological investigation. Conclusions: The main pathogens showed higher antimicrobial resistant rate and the selection of empiric antibiotics should take into consideration local epidemiology, antibiotic resistance patterns and the suspected causative microorganism.

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“…Rifampicin could also be considered as supplementary therapy together with vancomycin or linezolid. Rifampicin must not be used as monotherapy to avoid the development of resistance [38].…”

Section: Discussionmentioning

confidence: 99%

The microbiology and clinical characteristics of bacterial and fungal meningitis in a Chinese hospital

Chen¹,

Hu²,

Liu³

2017

Arch Med Sci Civil Dis

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“…In 2016, European guidelines for the diagnosis and treatment of acute bacterial meningitis were published by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) 10 . The guidelines state that empirical treatment with dexamethasone should be routine for all adults and children with acute bacterial meningitis in the setting of high-income countries.…”

Section: Year In Reviewmentioning

confidence: 99%

“…The guidelines state that empirical treatment with dexamethasone should be routine for all adults and children with acute bacterial meningitis in the setting of high-income countries. The guideline strongly recommends starting antibiotic therapy as soon as possible, and no more than 1 h after arrival at hospital 10 . To summarize, 2016 was an exciting year for the CNS infections field.…”

Section: Year In Reviewmentioning

confidence: 99%

2016, the year of Zika virus

Beek

Brouwer

2017

Nat Rev Neurol

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“…The most frequent complaint is headache. Since lumbar puncture is considered to be contraindicated [1] , cranial imaging is the most valuable method for diagnosis and follow-up. Radiological imaging is also a guide in determining the duration of treatment.…”

mentioning

confidence: 99%

“…After the etiologic agents were identified in our case, ceftriaxone was switched to penicillin considering the studies in the literature [8,9] . Linezolid which is an alternative treatment option for central nervous system infections was preferred after an allergic reaction with penicillin developed [1] . Due to possible side effects of vancomycin, linezolid was preferred.…”

mentioning

confidence: 99%

A Case of Polymicrobial Brain Abscess Caused By a Rare Bacterium: Granulicatella elegans

Akyol¹,

Yildirim²,

Taşbakan³

et al. 2018

mjima

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ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

Abstract: Key Question 1. What are the causative microorganisms of community-acquired bacterial meningitis in specific groups (neonates, children, adults and immunocompromised patients)?

Cited by 582 publications

References 133 publications

The microbiology and clinical characteristics of bacterial and fungal meningitis in a Chinese hospital

The microbiology and clinical characteristics of bacterial and fungal meningitis in a Chinese hospital

2016, the year of Zika virus

A Case of Polymicrobial Brain Abscess Caused By a Rare Bacterium: Granulicatella elegans

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