Esclerosis múltiple familiar en Canarias

Amela-Peris, R; Aladro, Yolanda; Ma, Conde-Sendín; Mj, Alemany-Rodríguez; Muñoz-Fernández, C; Mp, Reyes-Yáñez; Mc, Déniz-Naranjo; Sánchez‐García, Francisco Javier

doi:10.33588/rn.3910.2004280

Cited by 5 publications

(1 citation statement)

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“…Data about disease severity are likewise scarce. A study from Canary Islands shows that MS familial forms had more benign course compared to MS sporadic cases (Amela-Peris et al, 2004). The analysis was not stratified according to HLA-DR15 status -although more than half of the familial forms had the HLA-DRB1*1501 allele.…”

Section: Discussionmentioning

confidence: 99%

Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?

Bernardes

Paiva

Paradela

et al. 2019

Journal of Neuroimmunology

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Background: The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population. Methods: Association analyses between DR15 and the clinical and demographic variables were made. Results: We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P < .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018).

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Section: Discussionmentioning

confidence: 99%