Escherichia coli lipopolysaccharides and Staphylococcus aureus enterotoxin B differentially modulate inflammatory microRNAs in bovine monocytes

Dilda, Francesca; Gioia, G.; Pisani, Laura Francesca; Restelli, Liliana; Lecchi, Cristina; Albonico, F.; Bronzo, V.; Mortarino, Michele; Ceciliani, Fabrizio

doi:10.1016/j.tvjl.2011.08.018

Cited by 47 publications

(37 citation statements)

References 11 publications

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“…54 MiR-9 was also induced by LPS and Staphylococcus aureus enterotoxin B in bovine monocytes. 55 By contrast, in our study we demonstrate synergistic upregulation of miR-9 expression by IFN-g/LPS in pulmonary macrophages. LPS stimulation alone (at 5 ng/mL) was not sufficient to induce miR-9 expression.…”

Section: Discussioncontrasting

confidence: 89%

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Tay

Maltby

et al. 2015

Journal of Allergy and Clinical Immunology

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Section: Discussioncontrasting

confidence: 89%

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Tay

Maltby

et al. 2015

Journal of Allergy and Clinical Immunology

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“…More importantly, the target gene TLR4 (miR-146a/b) involved in nonspecific immunity (innate immunity) is not only an important class of protein molecules, but is also the connection between non-specific and specific immunity, when microorganisms break through the body's physical barriers, such as skin or mucous membranes. It has been reported that miR-146a has an anti-inflammatory function and is up-regulated after lipopolysaccharide (LPS) challenge on monocytes (Dilda et al 2012). This finding does not agree with the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

Identification and bioinformatics analysis of microRNAs associated with stress and immune response in serum of heat-stressed and normal Holstein cows

Zheng

Chen

Zheng

et al. 2014

Cell Stress and Chaperones

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MicroRNAs (miRNAs) are small single-stranded non-coding RNAs that have an important regulatory function in animal growth and developmental processes. However, the differential expression of miRNA and the role of these miRNAs in heat-stressed Holstein cows are still unknown. In this study, the profile of differentially expressed miRNAs and the target genes analysis in the serum of heat-stressed and normal Holstein cows were investigated by a Solexa deepsequencing approach and bioinformatics. The data identified 52 differentially expressed miRNAs in 486 known miRNAs which were changed significantly between heat-stressed and normal Holstein cows (fold change >2, P<0.001). Target genes analysis showed that at least 7 miRNAs (miR-19a, miR-19b, miR-146a, miR-30a-5p, miR-345-3p, miR-199a-3p, and miR-1246) were involved in the response to stress, oxidative stress, development of the immune system, and immune response among the identified 52 differentially expressed miRNAs. Five miRNAs (miR-27b, miR-181a, miR-181b, miR-26a, and miR-146b) were involved in stress and immune responses and the expression of five miRNAs was striking (P<0.001). In addition, RT-qPCR and deepsequencing methods showed that 8 miRNAs among the 12 selected miRNAs (miR-19a, miR-19b, miR-27b, miR-30a-5p, miR-181a, miR-181b, miR-345-3p, and miR-1246) were highly expressed in the serum of heat-stressed Holstein cows. GO and KEGG pathway analysis showed that these differentially expressed miRNAs were involved in a pathway that may differentially regulate the expression of stress response and immune response genes. Our study provides an overview of miRNAs expression profile and the interaction between miRNAs and their target genes, which will lead to further understanding of the important roles of miRNAs in heat-stressed Holstein cows.

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“…Four of the fourteen miRNAs were found to undergo differential expression (Table 1). Another study compared transcriptional changes of five inflammation-associated miRNAs, including ones with extensively studied human orthologs: bta-miR-155, bta-miR-146a, and bta-miR-223, in bovine CD14 + monocytes stimulated with either LPS or Staphylococcus aureus enterotoxin B (SEB) (45). Four miRNAs were differentially expressed, and LPS was found to have a greater effect than SEB at inducing miRNA differential expression.…”

Section: Role Of the Mirnas In The Bovine Immune Systemmentioning

confidence: 99%

The Role of microRNAs in Bovine Infection and Immunity

et al. 2014

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MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the immune defense during infection is critical to understanding the etiology of the most prevalent bovine diseases. Here, we review current knowledge of miRNAs in the bovine genome, and discuss the advances in understanding of miRNAs as regulators of immune cell function, and bovine immune response activation, regulation, and resolution. Finally, we consider the future perspectives on miRNAs in bovine viral disease, their role as potential biomarkers and in therapy.

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Escherichia coli lipopolysaccharides and Staphylococcus aureus enterotoxin B differentially modulate inflammatory microRNAs in bovine monocytes

Cited by 47 publications

References 11 publications

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Identification and bioinformatics analysis of microRNAs associated with stress and immune response in serum of heat-stressed and normal Holstein cows

The Role of microRNAs in Bovine Infection and Immunity

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