Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells

Eaves-Pyles, Tonyia; Allen, Christopher A.; Taormina, Joanna; Swidsinski, Alexander; Tutt, Christopher B.; Jezek, G. Eric; Islas-Islas, Martha; Torres, Alfredo G.

doi:10.1016/j.ijmm.2007.05.011

Cited by 156 publications

(152 citation statements)

References 44 publications

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“…Such pathogenic strains, called adherentinvasive E. coli (AIEC), are achieving increasing relevance since various studies performed in several countries (France, 8 the United Kingdom, 4 Spain 9 and the USA) [10][11][12] have reported them to be more prevalent in CD patients than in controls. The presence of AIEC in healthy subjects suggests that AIEC are facultative pathogens that cause disease in susceptible hosts.…”

mentioning

confidence: 99%

Abnormal CEACAM6 expression in Crohn disease patients favors gut colonization and inflammation by Adherent-InvasiveE. coli

Barnich

Darfeuille‐Michaud²

2010

Virulence

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mentioning

confidence: 99%

Abnormal CEACAM6 expression in Crohn disease patients favors gut colonization and inflammation by Adherent-InvasiveE. coli

Barnich

Darfeuille‐Michaud²

2010

Virulence

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“…Martha Islas Islas del Centro de Investigaciones Microbiológicas del Instituto de Ciencias, en coautoría con siete investigadores de Estados Unidos y Alemania, en una comunicación científica (Eaves et al, 2008) (29/30/34 citas) refieren que la cepa de E. coli O83:H1 posee las características de la nueva categoría denominada E. coli Adherente Invasiva (AIEC). Esta cepa, junto con otras tres, fue aislada de pacientes con enfermedad de Crohn para evaluar su capacidad para inducir la inflamación en dos líneas de células intestinales (Caco-2BBe y T84).…”

Section: Evaluación De La Capacidad De Cepas De E Coli Para Inducir unclassified

Características de la producción científica de instituciones de Puebla indexada en la Web of Science

Díaz-Cárdenas

Sankey-García

Díaz-Furlong

et al. 2018

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En este artículo describimos el ámbito de la investigación en el estado de Puebla, México, cuyos resultados han sido publicados en revistas indizadas en la Web of Science (WoS). El corpus examinado fue recopilado mediante el procedimiento de búsqueda con la palabra “puebla” en los campos organización y dirección, restringido al periodo 2008-2012. Como se desprende de los datos obtenidos la Universidad Autónoma de Puebla y el Instituto Nacional de Astrofísica, Óptica y Electrónica son los organismos más productivos del estado de Puebla. Nos centramos en los 102 artículos más citados del periodo y observamos que la producción científica con participación de instituciones poblanas se concentra en las ciencias físicas y biomédicas. Esta producción, mayoritariamente, proviene de colaboraciones de carácter internacional y las publicaciones más citadas presentan al menos tres autores; mientras que los textos de responsabilidad individual tienen poco impacto, de acuerdo con el número de citas registradas. Asimismo, estudiamos las diferencias por áreas científicas en cuanto a producción e impacto en términos de citas.AbstractThis article describes the scope and characteristics of the research developed in the state of Puebla, Mexico, whose results have been published in journals indexed in the Web of Science. The analyzed corpus was compiled by the search procedure with the word “puebla” in the organization and address fields, restricted to the period 2008-2012. We observed from the data obtained that the Universidad Autónoma de Puebla and the Instituto Nacional de Astrofísica, Óptica y Electrónica are the most productive institutions of Puebla. Our focus was on the 102 most cited articles of the period. Scientific production of Puebla institutions focuses on the physical and biomedical sciences and this production derives mostly from international collaborations. The multiauthor articles (at least three authors) are the most cited publications, while the individual research papers have little impact according to their number of citations. Finally, we analyze the differences in impact factor across scientific fields.

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“…AIEC adhere to the ileal mucosa through binding to molecules, which are overexpressed during CD (80,81). AIEC can also disrupt the integrity of polarized cell monolayer, breach the intestinal barrier and penetrate into the gastrointestinal epithelium (82). By expressing long polar fimbriae, the bacteria interact with mouse and human Peyer's patches and translocate across microfold cells monolayers (83).…”

Section: Gut Microbiotamentioning

confidence: 99%

Crohn’s Disease: a Role of Gut Microbiota and Nod2 Gene Polymorphisms in Disease Pathogenesis

Hrncírová

Krejsek

Šplı́chal

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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Crohn’s disease is a chronic immune-mediated intestinal inflammation targeted against a yet incompletely defined subset of commensal gut microbiota and occurs on the background of a genetic predisposition under the influence of environmental factors. Genome-wide association studies have identified about 70 genetic risk loci associated with Crohn’s disease. The greatest risk for Crohn’s disease represent polymorphisms affecting the CARD15 gene encoding nucleotide-binding oligomerization domain 2 (NOD2) which is an intracellular sensor for muramyl dipeptide, a peptidoglycan constituent of bacterial cell wall. The accumulated evidence suggests that gut microbiota represent an essential, perhaps a central factor in the induction and maintaining of Crohn’s disease where dysregulation of normal co-evolved homeostatic relationships between intestinal microbiota and host mucosal immune system leads to intestinal inflammation. Taken together, these findings identify Crohn’s disease as a syndrome of overlapping phenotypes that involves variable influences of genetic and environmental factors. A deeper understanding of different genetic abnormalities underlying Crohn’s disease together with the identification of beneficial and harmful components of gut microbiota and their interactions are essential conditions for the categorization of Crohn’s disease patients, which enable us to design more effective, preferably causative, individually tailored therapy.

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Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells

Cited by 156 publications

References 44 publications

Abnormal CEACAM6 expression in Crohn disease patients favors gut colonization and inflammation by Adherent-InvasiveE. coli

Abnormal CEACAM6 expression in Crohn disease patients favors gut colonization and inflammation by Adherent-InvasiveE. coli

Características de la producción científica de instituciones de Puebla indexada en la Web of Science

Crohn’s Disease: a Role of Gut Microbiota and Nod2 Gene Polymorphisms in Disease Pathogenesis

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