Escherichia Coli Endotoxin and Enterotoxin Implication on Pharmacokinetics of Drugs

Trimethoprim (TMP) 10 mg.kg-1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 micrograms.kg-1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced in both species a significant increase of TMP serum levels positively correlated with temperature elevation. Peptidoglycan pretreatment increased the bioavailability of TMP.

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“…Lower plasma levels and lower bioavailability after endotoxin pretreatment has been described for several drugs (1,3,9,10,11,12). After i.v.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand after endotoxin pretreatment lower serum levels of the same drugs have been observed (3). In the present study, it was considered of interest to examine the effect on drug kinetics of a different type of pyrogen, streptococcal Peptidoglycan.…”

Section: Introductionmentioning

confidence: 99%

Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan

Lavický

Černý²,

Čeleda³

et al. 1986

European Journal of Drug Metabolism and Pharmacokinetics

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Endotoxin and Pharmacokinetics of Rifampicin

Lavický

Čeleda²,

Urbanová

et al. 1985

Archives of Toxicology

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Fever and associated clinical haematologic and blood biochemical changes in the goat and other animal species

Miert¹

1985

Veterinary Quarterly

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SUMMARY Acute febrile diseases are characterized by specific and non-specific symptoms. The non-specific responses are presented under the headings: fever, inflammation and pain, experimental models for investigating febrile reactions, haematologic changes, blood biochemical changes, cardiovascular effects, changes in gastric function, and the effects offever upon pharmacokinetics of drugs.It was the purpose of this review to describe present concepts of thermoregulation and fever, the associated reactions produced by bacterial pyrogens and the mechanisms of these reactions. The available data illustrate, that many questions have not yet been clearly answered.However, the entire field of research involving endogenous substances, such as interleukin-I, is now moving ahead with great speed. Furthermore, there is some evidence which suggests that fever and the associated lower plasma zinc and iron levels act together as a co-ordinated non-specific host defence mechanism. Since experimental fever has a distinct effect upon the pharmacokinetics of drugs, more attention should be given to this aspect.

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Escherichia Coli Endotoxin and Enterotoxin Implication on Pharmacokinetics of Drugs

Cited by 5 publications

References 9 publications

Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan

Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan

Endotoxin and Pharmacokinetics of Rifampicin

Fever and associated clinical haematologic and blood biochemical changes in the goat and other animal species

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