Escherichia coli biofilms: Accepting the therapeutic challenges

Antibiotic susceptibility pattern of biofilm forming uropathogenic Escherichia coli isolated from UTI infected patients of Koshi Zonal Hospital in Biratnagar, Nepal

“…Among 23 E. coli isolates, 16 (70%) isolates showed biofilm formation dividing it into high, moderate and low biofilm formation. The results are in good agreement with the literature [26][27][28][29].…”

“…The investigation revealed that the biofilm forming UPEC were mostly resistant to erythromycin (100%) followed by amoxicillin (86%) which resembles other studies [7,26,27,29]. On the basis of our findings, antibiotic such as erythromycin and amoxicillin should be no longer recommended for initial therapeutics for urinary tract infections caused by biofilm-forming UPEC.…”

Multiple-drug Resistance among Biofilm-producing Phenotypes of Nosocomial Escherichia coli

“…Here, we reveal that a significant proportion of the biofilm producing E. coli isolates examined were multidrug resistant. This is similar to the report of Bajpai et al [20] who observed a significant correlation between biofilm formation and multidrug resistance while working on clinical isolates of E. coli.…”

Phylogenetic Group B2 Expressed Significant Biofilm Formation among Drug Resistant Uropathogenic Escherichia coli

“…It is estimated that biofilm is accountable for 80% of all microbial infections and over 65% of nosocomial infections [ 7 , 13 , 14 ]. Biofilm also plays an important role in horizontal gene transfer (HGT) facilitated by highly dense cells in close proximity [ 15 ] which facilitate movement of resistance genes and virulence factors, especially under selective pressure of antibiotic (s) [ 10 , 16 ]. Bacteria in biofilm are metabolically less active, resistant to exogenous environmental stress, like antibacterial agents, due to mass transfer limitations in the biofilm matrix [ 17 ].…”