Escaping from, moving towards, following a path, squeezing through: lots of opportunities for moving cells

Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells

“…Further, TISCs are capable of metastasizing [ 32 – 34 ]. The ability of TISCs to metastasize is determined by the property of these cells to undergo epithelial-mesenchymal transition [ 35 – 39 ]. Remodeling of the cytoskeleton occurs, and factors altering the structure of the extracellular matrix in the cellular environment become expressed.…”

Sperm Dynamics in Tubular Confinement

“…Transparent rolled-up microtubes have recently been Recent studies suggest that the in vivo microenvironment plays a decisive role for the behavior of motile cells. [1][2][3] It has been an on-going challenge to mimic environments of motile cells in order to investigate the interaction of moving cells and their surroundings. Especially, microenvironments of tubular shape that can be found widely in nature such as in sperm migration, [ 4 ] artery networks, lymphatic vascular systems, [ 5 ] or during the formation of biofi lms by bacterial motility, [ 6,7 ] have been challenging to reproduce in vitro.…”