ESBL and carbapenemase-producing Enterobacteriaceae in infectious pleural effusions: current epidemiology at Hôpital du Mali

Kalambry, Aimé Césaire; Potindji, Tchamou Malraux Fleury; Guindo, Ibrehima; Kassogué, Ambara; Drame, Boubacar Sidiki Ibrahim; Togo, Seydou; Yena, Sadio; Doumbia, Seydou; Diakite, Mahamadou

doi:10.33393/dti.2023.2613

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…One hundred and ten were diagnosed with enterobacterial pleuritis, mainly E. coli, K. pneumoniae and Proteus mirabilis. Three isolates (2.72%), one K. pneumoniae and two Providencia spp., tested positive for bla NDM-1 [93].…”

Section: Resultsmentioning

confidence: 99%

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Chelaru,

Muntean,

Hogea

et al. 2024

Antibiotics

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Antimicrobial resistance (AMR) is a worldwide healthcare problem. Multidrug-resistant organisms (MDROs) can spread quickly owing to their resistance mechanisms. Although colonized individuals are crucial for MDRO dissemination, colonizing microbes can lead to symptomatic infections in carriers. Carbapenemase-producing Enterobacterales (CPE) are among the most important MDROs involved in colonizations and infections with severe outcomes. This review aimed to track down the first reports of CPE in Africa, describe their dissemination throughout African countries and summarize the current status of CRE and CPE data, highlighting current knowledge and limitations of reported data. Two database queries were undertaken using Medical Subject Headings (MeSH), employing relevant keywords to identify articles that had as their topics beta-lactamases, carbapenemases and carbapenem resistance pertaining to Africa or African regions and countries. The first information on CPE could be traced back to the mid-2000s, but data for many African countries were established after 2015–2018. Information is presented chronologically for each country. Although no clear conclusions could be drawn for some countries, it was observed that CPE infections and colonizations are present in most African countries and that carbapenem-resistance levels are rising. The most common CPE involved are Klebsiella pneumoniae and Escherichia coli, and the most prevalent carbapenemases are NDM-type and OXA-48-type enzymes. Prophylactic measures, such as screening, are required to combat this phenomenon.

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Section: Resultsmentioning

confidence: 99%

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

Chelaru,

Muntean,

Hogea

et al. 2024

Antibiotics

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show abstract

The Impact of Carbapenemase Producing Enterobacterales in African Countries: Evolution, Current Burden and Importance of Colonizations

Chelaru,

Muntean,

Hogea

et al. 2024

Preprint

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Antimicrobial resistance (AMR) is a worldwide healthcare problem. Multidrug resistant organisms (MDRO) have the ability to spread quickly owing to their resistance mechanisms. Although colonized individuals are crucial MDRO dispensers, colonizing microbes have the potential to turn pathogenic under certain conditions, leading to symptomatic infections in carriers. Carbapenemase producing Enterobacterales (CPE) are among the most important MDRO involved in infections and colonizations, associating with multiple resistance mechanisms and virulence factors, causing infections with severe outcomes. All research papers identified in the most comprehensive online databases which contained information related to the topic of this article were analyzed, and relevant data was extracted and included. The first information on CPE could be traced back to the mid-2000s, but pertinent data for many African countries was established in the past 5-8 years. Information is presented chronologically for each country. Although no clear conclusions could be drawn for some countries, it was observed that CPE colonizations are present in most African countries and carbapenem-resistance levels are rising. The most common CPE involved are Klebsiella pneumoniae and Escherichia coli, and the most prevalent carbapenemases are NDM-type and OXA-48-type enzymes. Prophylactic measures, such as screening, are required to combat this phenomenon.

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Inoculation of pleural fluid in blood culture bottles could be a routine practice in pleural infection

Amer,

Gad,

El Akhal

2024

Egypt J Chest Dis Tuberc

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Background Worldwide, pleural infections are becoming more common. Overuse of empirical antibiotics has been linked to longer hospital stays and higher death rates, causing the emergence of antibiotic-resistant pathogens. So, proper care requires the identification of the pathogenic bacteria using pleural fluid culture. In addition to normal culture, pleural fluid inoculation in blood culture bottles enhances the proportion of patients with detectable infections in less time. Aim To assess whether inoculating pleural fluid into a blood culture bottle will increase the yield of isolated pathogens compared to routine culture techniques in evaluating pleural infection. Also, to compare the time of pathogen detection when comparing the detection by blood culture bottle versus the routine microbiological culture technique. Recognize the distribution of isolated bacteria from our center and their susceptibility profile to different antibiotics and predict the most effective empirical antibiotics. Patients and methods Cross-sectional analytical prospective study conducted at the Department of Pulmonology and Clinical Pathology in Cairo University Hospitals. It included 70 patients with infected pleural effusion. Under ultrasound supervision, pleural fluid was extracted and transported to the laboratory for routine microbiological culture. At the same time, an automated blood culture bottle was inoculated with 5–10 ml to be incubated. All the detected pathogens were identified and tested for antimicrobial susceptibility according to CLSI. Results The mean age of our patients was 47.1 ± 15.6 years. Empyema was documented in 16 (22.9%) of our patients, whereas 54 (77.1%) had exudative pleural effusion. Positive aerobic infection in blood culture bottle was seen in 37 patients, compared to 21 patients in direct pleural culture. A statistically significant difference was found between the culture positive rate in aerobic blood culture bottles and direct pleural culture (P=0.001). Conclusion Blood culture bottle inoculation of infected pleural fluid increases the sensitivity of microbial yield in a shorter time than standard culture.

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ESBL and carbapenemase-producing Enterobacteriaceae in infectious pleural effusions: current epidemiology at Hôpital du Mali

Cited by 3 publications

References 39 publications

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden

The Impact of Carbapenemase Producing Enterobacterales in African Countries: Evolution, Current Burden and Importance of Colonizations

Inoculation of pleural fluid in blood culture bottles could be a routine practice in pleural infection

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