ES&amp;T Critical Review: Environmental monitoring by immunoassay

Vanderlaan, Martin; Watkins, Bruce E.; Stanker, Larry H.

doi:10.1021/es00168a002

Cited by 113 publications

(50 citation statements)

References 19 publications

(23 reference statements)

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“…Reliable and inexpensive methods are required to monitor more extensively contaminant concentrations in pumping wells and biological tissues. In this regard, immunoassays have been developed for monitoring contaminants in water, soil, food, and biological tissues (138)(139)(140)(141)(142)(143)(144)(145)(146)(147)(148)(149)(150)(151). Data from these assay systems, along with standardized chromatography/mass spectroscopy chemical analysis methods, make it possible to randomize the transport parameters in contaminant transport and PBPK models in a more reliable manner.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Health Risks for Contaminated Aquifers

Piver¹,

Jacobs²,

Medina³

1997

Environmental Health Perspectives

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Section: Discussionmentioning

confidence: 99%

Evaluation of Health Risks for Contaminated Aquifers

Piver¹,

Jacobs²,

Medina³

1997

Environmental Health Perspectives

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“…Immunoassays are widely used for detecting analytes (antigens) for diagnostics, (Wild 2005a) environmental monitoring, (Vanderlaan et al 1988) therapy monitoring, (Mair et al 1992) research in the life sciences and food safety, (Samarajeewa et al 1991) for example. Platforms for immunoassays differ widely, from clinical analyzers ran by expert staff to lateral flow tests used at home for pregnancy testing.…”

Section: Introductionmentioning

confidence: 99%

Autonomous capillary system for one-step immunoassays

Zimmermann

Hunziker

Delamarche

2008

Biomed Microdevices

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Autonomous capillary systems (CSs), in which liquids are transported owing to capillary forces, have been previously used to perform fast and sensitive multi-step immunoassays using minute volumes of analyte. CSs for diagnostic applications have different requirements than CSs that are used as a research tool in life sciences, where a high flexibility and performance prevail over ease of use and portability. In this paper a proof-of-concept for one-step immunoassays based on CSs is demonstrated. This proof-of-concept is based on preloading detection antibodies (dAbs) on the flow path of analytes and redissolving these antibodies to form dAb-analyte complexes, which can be detected using fluorescence downstream on accurately patterned capture antibodies. A user therefore only needs to load a sample at the beginning of a CS and obtains the result of the assay using a conventional fluorescence microscope or scanner. As an example, C-reactive protein was detected in human serum at clinical concentrations within 10 min and using only microL of sample.

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“…Due to their low cost, simplicity, versatility and relatively high specificity, immunoassays are widely used in life science research, drug discovery, clinical diagnostics and environmental monitoring [1,2]. Since radioisotope-labeled immunoassays were first introduced [3] in 1959, a vari-label stability and assay flexibility.…”

Section: Introductionmentioning

confidence: 99%