Erythropoietin

Gordon, Albert S.

doi:10.1016/s0083-6729(08)60997-8

Cited by 36 publications

(5 citation statements)

References 284 publications

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“…Erythropoiesis in the mammalian fetus and the adult is regulated by the hormone erythropoietin (Ep)l (1,2). Although Ep is produced mainly by the kidneys in the normal adult (3), a numl)er of sttudies have demonstrated the existence of extrarenal sources that, when appropriately stimulated, can produce about 5-10% of the Ep normally evoked in intact adults (4).…”

Section: Introductionmentioning

confidence: 99%

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Zanjani¹,

Banisadre²

1979

J. Clin. Invest.

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A B S T R A C T The effect of testosterone (DT) and thyroxin (L-T4) on erythropoiesis and erythropoietin (Ep) These data demonstrate that (a) DT aind L-T4 are effective promnoters of extrarenal Ep production, thereby enhancing erythropoiesis in intact and nephrectomized fetuses; (b) DT is a stronger stimulus of extrarenal Ep formation than L-T4; and (c) Ep is required for the expression of the erythropoietic effects of L-T4 and DT.

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Section: Introductionmentioning

confidence: 99%

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Zanjani¹,

Banisadre²

1979

J. Clin. Invest.

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“…Erythrocyte production in normal animals and man is regulated by the hormone erythropoietin (Ep)l (1).…”

Section: Introductionmentioning

confidence: 99%

Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin.

Zanjani¹,

Lutton²,

Hoffman³

et al. 1977

J. Clin. Invest.

161

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A B S T R A C T In the plasma clot culture system, both normal and polycythemia vera (PV) bone marrow cells respond to erythropoietin (Ep), giving rise to large numbers of colonies of erythroid cells. In PV, but not in normal individuals, the marrow produced endogenous erythroid colonies (EEC) in the absence of exogenous Ep. The number of EEC formed varied from patient to patient comprising anywhere from 6 to 29% of the total number of colonies formed in the presence of Ep. Exposure, before use in culture, of fetal calf serum and citrated bovine plasma to the gammaglobulin fraction of rabbit anti-Ep serum followed by treatment with goat anti-rabbit gamma-globulin resulted in a significant decrease in EEC formation. Addition of anti-Ep directly to the culture medium produced similar results. In addition, the production of EEC in response to added Ep was inhibited in the presence of anti-Ep. Addition of very small doses of highly purified Ep to anti-Ep-treated cultures resulted in the reappearance of a significant number of EEC. These results suggest that EEC formation in PV may be due to a population of erythroid-committed precursors that are abnormally sensitive to small concentrations of Ep which may be present in fetal calf serum and citrated plasma. Although the mechanism of formation of these cells is not known, it appears that the final steps in the formation of red cells derived from this clone of precursors is subject to the usual Ep control.

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“…Thymic hormones: Control the proliferation and maturation of primitive lymphocytes into immunologically competent T cells (Bach, 19771 Erythropoietin: Induces mitosis in proerythrocytes, giving rise to hemoglobin-synthesizing cells (Gordon, 1973). Colony-stimulating factor and macrophage growth factor: Stimulate primitive bone marrow cells and macrophages to proliferate (Stewart and Lin, 1978)" Ovarian growth factor: Prolongs the survival of cultured ovarian cells (Gospodarowicz et al, 1974).…”

Section: Other Growth Factorsmentioning

confidence: 99%

Human Growth

1986

106

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Erythropoietin

Cited by 36 publications

References 284 publications

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin.

Human Growth

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