Current Opinion in Hematology 2010 DOI: 10.1097/moh.0b013e328338008b View full text
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Don M Wojchowski, Pradeep Sathyanarayana, Arvind Dev

Abstract: AbstractPurpose of review-In 1985-1989 EPO, its receptor (EPOR) and JAK2 were cloned; established to be essential for definitive erythropoiesis; and initially intensely studied. Recently, new impetus, tools, and model systems have emerged to re-examine EPO/EPOR actions -and are addressed in this review. Impetus includes indications that EPO affects significantly more than standard erythroblast survival pathways; the development of novel erythropoiesis stimulating agents (ESA's); increasing evidence for EPO/EP…

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