Don M Wojchowski, Pradeep Sathyanarayana, Arvind Dev
AbstractPurpose of review-In 1985-1989 EPO, its receptor (EPOR) and JAK2 were cloned; established to be essential for definitive erythropoiesis; and initially intensely studied. Recently, new impetus, tools, and model systems have emerged to re-examine EPO/EPOR actions -and are addressed in this review. Impetus includes indications that EPO affects significantly more than standard erythroblast survival pathways; the development of novel erythropoiesis stimulating agents (ESA's); increasing evidence for EPO/EP…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute of Drug Abuse of the National Institutes of Health.