Erythropoietin protects from reperfusion-induced myocardial injury by enhancing coronary endothelial nitric oxide production☆☆☆

Mihov, Deyan; Bogdanov, Nikolay; Grenacher, Beat; Gassmann, Max; Zünd, Gregor; Bogdanova, Anna; Tavakoli, Reza

doi:10.1016/j.ejcts.2008.12.049

Cited by 35 publications

(34 citation statements)

References 24 publications

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“…These effects of Epo were confirmed for isolated cells as well as in vivo in hearts after intravenous Epo administration. In the latter case Akt and eNOS phosphorylation is restricted to the endothelial cells of coronary vessels (147). In cardiomyocytes the direct cytoprotective effect of Epo is mediated by its regulatory action on calcium handling and stabilization of the mitochondria.…”

Section: Epor In the Heartmentioning

confidence: 99%

“…Whether long term Epo treatment causes similar effects remains unclear. Epo binding to its receptors induces phosphorylation of Akt and eNOS -its effects are seen within 5 min (147) and can be observed for the first hour and thereafter the Epo-EpoR complex is internalized and degraded (Mihov, Tavakoli, Bogdanova unpublished observations). The internalization rate constant for Epo-EpoR complex in UT-7/Epo cells is 0.06 min −1 (172).…”

Section: Epor In the Heartmentioning

confidence: 99%

“…Plasma-borne Epo most likely does not reach cardiomyocytes (147). Thus, the cytokine should be generated by one or more cell types within the myocardium and then be released for autocrine/paracrine receptor activation similar to that in the brain (Fig.…”

Section: Epor In the Heartmentioning

confidence: 99%

See 2 more Smart Citations

Epo and Non-hematopoietic Cells: What Do We Know?

Ogunshola

Bogdanova

2013

Methods in Molecular Biology

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Section: Epor In the Heartmentioning

confidence: 99%

Section: Epor In the Heartmentioning

confidence: 99%

See 1 more Smart Citation

Epo and Non-hematopoietic Cells: What Do We Know?

Ogunshola

Bogdanova

2013

Methods in Molecular Biology

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“…Nitric oxide (NO) availability is a crucial element in the protection of the heart from hypoxic injury. NOSs are known as O 2 sensors and are capable of generation of both antioxidative and cytoprotective NO, and superoxide anion, giving rise to prooxidative hydrogen peroxide and hydroxyl radical (Mihov et al 2009a(Mihov et al , 2009b. Generation of NO is an oxygen-dependent process because oxygen is a substrate of NOSs along with l-arginine.…”

Section: Rescuing the Hypoxic Heart: Nitrite And No In Cardioprotectionmentioning

confidence: 99%

First Aid Kit for Hypoxic Survival: Sensors and Strategies

López‐Barneo¹,

Nurse²,

Nilsson³

et al. 2010

Physiological and Biochemical Zoology

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Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral chemoreception, optimization of oxygen extraction from the hypoxic environment and its delivery to the periphery, and adjustments of energy production and consumption. This article uses a comparative approach to assess the efficiency of adaptive strategies used by anoxia-tolerant and hypoxia-sensitive species to support survival during the first minutes to 1 h of oxygen deprivation. An aquatic environment is much more demanding in terms of diurnal and seasonal variations of the ambient oxygen availability from anoxia to hyperoxia than is an air environment. Therefore, fishes and aquatic turtles have developed a number of adaptive responses, which are lacking in most of the terrestrial mammals, to cope with these extreme conditions. These include efficient central and peripheral chemoreception, acute changes in respiratory rate and amplitude, and acute increase of the gas-exchange interface. A special set of adaptive mechanisms are engaged in reduction of the energy expenditure of the major oxygen-consuming organs: the brain and the heart. Both reduction of ATP consumption and a switch to alterative energy sources contribute to the maintenance of ATP and ion balance in hypoxia-tolerant animals. Hypoxia and hyperoxia are conditions favoring development of oxidative stress. Efficient protection from oxidation in anoxia-tolerant species includes reduction in the glutamate levels in the brain, stabilization of the mitochondrial function, and maintenance of nitric oxide production under conditions of oxygen deprivation. We give an overview of the current state of knowledge on some selected molecular and cellular acute adaptive mechanisms. These include the mechanisms of chemoreception in adult and neonatal mammals and in fishes, acute metabolic adaptive responses in the brain, and the role of nitrite in the preservation of heart function under hypoxic conditions. ABSTRACTSurvival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral chemoreception, optimization of oxygen extraction from the hypoxic environment and its delivery to the periphery, and adjustments of energy production and consumption. This article uses a comparative approach to assess the efficiency of adaptive strategies used by anoxia-tolerant and hypoxia-sensitive species to support survival during the first minutes to 1 h of oxygen deprivation. An aquatic environment is much more demanding in terms of diurnal and seasonal variations of the ambient oxygen availability from anoxia to hyperoxia than is an air environment. Therefore, fishes and aquatic turtles have developed a number of adaptive responses, which are lacking in most of the terrestrial mammals, to cope with these extreme conditions. These include efficient central and peripheral chemoreception, acute changes in respiratory rate and amplitude, and acute increase of the gas-exchange interface. A special set of adaptive me...

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“…Animal studies have shown that cardio and neuro protection occur when EPO is administered for preconditioning strategy or administered during resuscitation from cardiac arrest as well as reduced prevalence of arrhythmias when given prior to focal I/R. (67,(70)(71)(72)(73)(74)(75) EPO administered during cardiac arrest and resuscitation in early human trials appears encouraging. (76)(77) …”

Section: Methods For Stimulating and Interacting With The Endotheliummentioning

confidence: 99%

Targeting the Endothelium

Adams

2010

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Erythropoietin protects from reperfusion-induced myocardial injury by enhancing coronary endothelial nitric oxide production☆☆☆

Cited by 35 publications

References 24 publications

Epo and Non-hematopoietic Cells: What Do We Know?

Epo and Non-hematopoietic Cells: What Do We Know?

First Aid Kit for Hypoxic Survival: Sensors and Strategies

Targeting the Endothelium

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